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Author: Derek H. R. Barton
Publisher: Elsevier Publishing Company
ISBN:
Category : Science
Languages : en
Pages : 542
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Book Description
Hardbound. This volume describes the dramatic advances in studies of the structure and function of enzymes which have led to an understanding of the rich chemistry used by nature to construct molecules and how the enzymes of natural products biosynthesis catalyze these reactions. Natural products are synthesized from simple precursors through a series of enzyme mediated reactions that are exquisitely selective and efficient. Questions about the mechanisms of these reactions and what features of enzyme catalytic sites are important for stabilizing transition states and reactive intermediates have been addressed by combining studies in mechanistic organic chemistry, structural biology, and molecular genetics. Except in rare instances, the enzymes of natural products biosynthesis are not found in abundance, and as a consequence, they are not readily available for study from natural sources. This situation has changed through the dramatic advances in gen
Author: Derek H. R. Barton
Publisher: Elsevier Publishing Company
ISBN:
Category : Science
Languages : en
Pages : 542
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Book Description
Hardbound. This volume describes the dramatic advances in studies of the structure and function of enzymes which have led to an understanding of the rich chemistry used by nature to construct molecules and how the enzymes of natural products biosynthesis catalyze these reactions. Natural products are synthesized from simple precursors through a series of enzyme mediated reactions that are exquisitely selective and efficient. Questions about the mechanisms of these reactions and what features of enzyme catalytic sites are important for stabilizing transition states and reactive intermediates have been addressed by combining studies in mechanistic organic chemistry, structural biology, and molecular genetics. Except in rare instances, the enzymes of natural products biosynthesis are not found in abundance, and as a consequence, they are not readily available for study from natural sources. This situation has changed through the dramatic advances in gen
Author: Derek H. R. Barton
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 988
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Book Description
Hardbound. This volume, containing 20 chapters, focuses on the biosynthesis of the different classes of carbohydrates and their derivatives. The first part of this volume concentrates on the three classes of glycan-bearing molecules that mediate bio-recognition events, namely, glycoproteins, glycolipids, and glycosaminoglycans. Thus, the first four chapters highlight the key role played by glycosidases and glycosyl transferases in the processing of glycan chains in glycoproteins and on inhibitors of the glycosidases. The next two chapters feature the biosynthesis of glycosphingolipids, sphingolipid transport and degradation, and the regulation of glycolipid biosynthesis in developing tissues and tumor cells. Chapter 7 is devoted to the biosynthesis of proteoglycans with particular emphasis on the glycosaminoglycans. In the second part, the volume treats the molecules of importance in protozoans and bacteria. Thus, chapter 8 describes the biosynthesis o
Author:
Publisher: Elsevier
ISBN: 0081026919
Category : Science
Languages : en
Pages : 4266
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Book Description
Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience
Author:
Publisher: Academic Press
ISBN: 0123786312
Category : Science
Languages : en
Pages : 3223
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Book Description
The 4-volume Encyclopedia of Biological Chemistry, Second Edition, represents the current state of a dynamic and crucial field of study. The Encyclopedia pulls together over 500 articles that help define and explore contemporary biochemistry, with content experts carefully chosen by the Editorial Board to assure both breadth and depth in its coverage. Editors-In-Chief William J. Lennarz and M. Daniel Lane have crafted a work that proceeds from the acknowledgement that understanding every living process-from physiology, to immunology, and genetics-is impossible without a grasp on the basic chemistry that provides its underpinning. Each article in the work provides an up-to-date snapshot of a given topic, written by experts, as well as suggestions for further readings for students and researcher wishing to go into greater depth. Available on-line via SciVerse ScienceDirect, the functionality of the Encyclopedia will provide easy linking to referenced articles, electronic searching, as well an online index and glossary to aid comprehension and searchability. This 4-volume set, thoroughly up-to-date and comprehensive, expertly captures this fast-moving field Curated by two esteemed editors-in-chief and an illustrious team of editors and contributors, representing the state of the field Suggestions for further readings offer researchers and students avenues for deeper exploration; a wide-ranging glossary aids comprehension
Author: Derek Barton
Publisher: Newnes
ISBN: 0080912834
Category : Science
Languages : en
Pages : 11380
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Book Description
Comprehensive Natural Products Chemistry
Author: Derek H. R. Barton
Publisher: Elsevier Publishing Company
ISBN:
Category : Science
Languages : en
Pages : 780
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Book Description
Hardbound. This volume is intended to cover the chemistry of one of the most widely studied and important natural products, DNA. Discussed in detail are physicochemical properties of the molecule itself as well as small-molecule natural products that are known to interact with it. Also included are methods to synthesize and manipulate DNA and modified analogues. Twenty chapters are devoted to this overall topic.The first five relate to the structure of DNA; the first focuses on thermodynamics and kinetics of double helix formation; the next two describe triple- and tetra- helical structures formed by DNA; and the last two focus on methods for probing DNA structure (specifically, NMR methods and chemical probing methods, respectively).Chapters 6-12 focus on the chemistry of natural DNA and modified analogues. The first of these addresses nonenzymatic methods for synthesizing DNA, and the next chapter, on methods for attachment of reporter groups t
Author: Alfred Hassner
Publisher: Elsevier
ISBN: 1483287343
Category : Science
Languages : en
Pages : 462
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Book Description
Synthetically useful organic reactions or reagents are often referred to by the name of the discoverer(s) or developer(s). Older name reactions are described in text books, but more recently developed synthetically useful reactions that may have been associated occasionally with a name are not always well known. For neither of the above are experimental procedures or references easy to find. In this monograph approximately 500 name reactions are included, of which over 200 represent newer name reactions and modern reagents. Each of these reactions are extremely useful for the contemporary organic chemistry researcher in industry or academic institutions. This book provides the information in an easily accessible form. In addition to seminal references and reviews, one or more examples for each name reaction are provided and a complete typical experimental procedure is included, to enable the student or researcher to immediately evaluate reaction conditions. Besides an alphabetical listing of reactions and reagents, cross references permit the organic practitioner to find those name reactions or reagents that enable specific transformations, such as, conversion of amines to nitriles, stereoselective reduction, fluoroalkylation, phenol alkynylation, asymmetric syntheses, allylic alkylation, nucleoside synthesis, cyclopentanation, hydrozirconation, to name a few. Emphasis has been placed on stereoselective and regioselective transformations as well as on enantioselective processes. The listing of reactions and reagents is supported by four indexes.
Author:
Publisher: Elsevier
ISBN: 0080453821
Category : Science
Languages : en
Pages : 7944
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Book Description
This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Derek H. R. Barton
Publisher: Elsevier Publishing Company
ISBN:
Category : Science
Languages : en
Pages : 348
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Book Description
Hardbound. This 19-chapter volume summarizes the current status of our understanding of RNA, with particular emphasis on the chemistry of this key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA and RNA enzymes (ribozymes). The different chapters detail biophysical and chemical methods to investigate RNA structure and function, the synthesis of native and modified RNAs and several chapters reviewing the latest advances in our understanding of the vast array of biological processes in which RNA is involved.The first five chapters deal with different approaches available to study RNA structure, covering NMR solution studies of secondary structure, thermodynamics, X-ray crystallographic approaches, RNA dynamics and the role of RNA structures in RNA: protein interactions.Three chapters are focused on RNA chemistry covering chemical and enzymatic probes for RNA, chemical RNA synthesis and the chemist
