Chemical Analysis of Non-antimicrobial Veterinary Drug Residues in Food PDF Download
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Author: Jack F. Kay
Publisher: John Wiley & Sons
ISBN: 1118695070
Category : Science
Languages : en
Pages : 641
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Book Description
Provides a single-source reference for readers interested in the development of analytical methods for analyzing non-antimicrobial veterinary drug residues in food Provides a comprehensive set of information in the area of consumer food safety and international trade Covers general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods Details many techniques including nanotechnology and aptamer based assays covering current and potential applications for non-antimicrobial veterinary drugs Provides guidance for analysis of banned drugs including natural and synthetic steroids, Resorcylic acid lactones, and Beta-agonists
Author: Jack F. Kay
Publisher: John Wiley & Sons
ISBN: 1118695070
Category : Science
Languages : en
Pages : 641
Get Book
Book Description
Provides a single-source reference for readers interested in the development of analytical methods for analyzing non-antimicrobial veterinary drug residues in food Provides a comprehensive set of information in the area of consumer food safety and international trade Covers general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods Details many techniques including nanotechnology and aptamer based assays covering current and potential applications for non-antimicrobial veterinary drugs Provides guidance for analysis of banned drugs including natural and synthetic steroids, Resorcylic acid lactones, and Beta-agonists
Author: Jian Wang
Publisher: John Wiley & Sons
ISBN: 1118067193
Category : Science
Languages : en
Pages : 378
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Book Description
An insightful exploration of the key aspects concerning the chemical analysis of antibiotic residues in food The presence of excess residues from frequent antibiotic use in animals is not only illegal, but can pose serious health risks by contaminating products for human consumption such as meat and milk. Chemical Analysis of Antibiotic Residues in Food is a single-source reference for readers interested in the development of analytical methods for analyzing antibiotic residues in food. It covers themes that include quality assurance and quality control, antibiotic chemical properties, pharmacokinetics, metabolism, distribution, food safety regulations, and chemical analysis. In addition, the material presented includes background information valuable for understanding the choice of marker residue and target animal tissue to use for regulatory analysis. This comprehensive reference: Includes topics on general issues related to screening and confirmatory methods Presents updated information on food safety regulation based on routine screening and confirmatory methods, especially LC-MS Provides general guidance for method development, validation, and estimation of measurement uncertainty Chemical Analysis of Antibiotic Residues in Food is written and organized with a balance between practical use and theory to provide laboratories with a solid and reliable reference on antibiotic residue analysis. Thorough coverage elicits the latest scientific findings to assist the ongoing efforts toward refining analytical methods for producing safe foods of animal origin.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309175771
Category : Medical
Languages : en
Pages : 276
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Book Description
The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.
Author: V.K. Agarwal
Publisher: Springer Science & Business Media
ISBN: 1461533562
Category : Medical
Languages : en
Pages : 260
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Book Description
In the last three decades. use of antibiotics/drugs in animal husbandry programs has grown tremendously. Antibiotics/drugs are used therapeutically to cure diseases. and subtherapeutically to control the outbreak of diseases, improve feed efficiency and promote growth. The presence of antibiotic/drug residues in food products of animal origin. i.e •• meat, poultry and milk, can be a potential health hazard to consumers. Significant research is being done to develop new methods or to improve on existing methods to confirm and quantitatively determine the antibiotic/drug residues in meat, poultry and milk. This book covers recent development and application of various analytical techniques for the determination of antibiotic/drug residues in food products of animal origin. I thank the authors for their time and efforts in preparing the manuscripts and "all the reviewers for reviewing the manuscripts. I also thank to the Division of Agricultural and Food Chemistry of the American Chemical Society for sponsoring the symposium and Hewlett Packard, Palo Alto, CA, Perkin Elmer Corp., Norwalk, CT, Millipore Corporation, Milford, MA, and Kraft General Foods, Glenview, IL, for their generous financial support for the symposium. Vipin K. Agarwal New Haven, CT v CONTENTS Importance of Laboratory Validations and Accurate Descriptions of Analytical Procedures for Drug Residues in Foods ................. .
Author: Jack F. Kay
Publisher: John Wiley & Sons
ISBN: 1119325919
Category : Science
Languages : en
Pages : 640
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Book Description
Provides a single-source reference for readers interested in the development of analytical methods for analyzing non-antimicrobial veterinary drug residues in food Provides a comprehensive set of information in the area of consumer food safety and international trade Covers general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods Details many techniques including nanotechnology and aptamer based assays covering current and potential applications for non-antimicrobial veterinary drugs Provides guidance for analysis of banned drugs including natural and synthetic steroids, Resorcylic acid lactones, and Beta-agonists
Author: Ronald E. Baynes
Publisher: John Wiley & Sons
ISBN: 0470247525
Category : Science
Languages : en
Pages : 340
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Book Description
Highlighting international approaches; the book details strategies to minimize contamination, residue monitoring programs, and classes of drugs and chemicals that pose contaminant risk in livestock. Focuses attention on drug and chemical residues in edible animal products Covers novel computational, statistical, and mathematical strategies for dealing with chemical exposures in food animals Details major drug classes used in food animal production and their residue risks Highlights efforts at harmonizing and the differences among areas like US, EU, Canada, Australia, South America, China, and Asia, where the issue of chemical exposures has significant impact on livestock products Ties veterinary clinical practice and the use of these drugs in food animals with regulatory standards and mitigation practices
Author: R. J. Heitzman
Publisher: Wiley-Blackwell
ISBN: 9780632037865
Category : Medical
Languages : en
Pages : 512
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Book Description
The purpose of this second edition is to bring together the current rapid developments and activities in residues of veterinary drugs within the European Community. The EEC legislation is summarised. There is information on the Reference Laboratories, the Maximum Residues Limits (MRL) and the criteria for the methods to be used for routine analysis of residues by Member States and third countries wishing to export meat to the EC. The current state of examination of residues practised and the analytical methods used in Member States is described in detail. There is a section on quality assurance in the laboratory and also supporting information on residues and chemical/physical data of the most important veterinary drugs
Author: Anca Baesu
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"Analytical techniques targeting specific analytes, i.e., targeted analysis, have long been established as the main methods in food safety and environmental analysis. On account of the large number of chemical contaminants with various physicochemical properties detected in the food and water, there is a need to adapt these methods to screen and identify a broader number of chemicals. Additionally, studies have shown a decrease in contaminant levels during cooking and with food, especially seafood, eaten following some sort of thermal processing, it is important to study the outcome of processing on food contaminants. The preferred technique to screen for, and study the fate of contaminants in food is non-targeted analysis (NTA) using high resolution mass spectrometry. The objective in this thesis was to develop a non-targeted method in food analysis, focusing on the determination of veterinary drugs and other pharmaceuticals (drugs used in human medicine) in fish and shrimp. Chapter 3 covers the first step in NTA, which is the selection of an extraction method. Malachite green (MG) exposed brook trout and pacific white shrimp were used as a case study to evaluate the impact of extraction methods on the determination of the veterinary drug. Based on the comparison parameters, e.g., extracted features, matrix, ionization mode, a different extraction was considered more suitable. Although a compromise must be reached, based on specific research objectives, there is a need for a more harmonized approach on some aspects, like data filtering, e.g., blank subtraction, and data processing. Overall, QuEChERS extraction provided satisfactory results and was chosen to further study MG. In Chapter 4, a data analysis approach was validated for compound discovery from non-targeted data, focusing on the identification of antimicrobials and other pharmaceuticals in fish livers. The validated workflow was suitable, as it led to the identification of an antibiotic, azithromycin, and an anti-depressant metabolite, erythrohydrobupropion. Chapter 5 covered the application of NTA for the identification of thermal transformation products (TPs) of MG and LMG in brook trout and shrimp, using the extraction and data analysis workflow validated in Chapters 3 &4. Boiling, canning and microwaving reduced MG levels in both brook trout and shrimp, with microwaving the only treatment successful in significantly reducing LMG levels. Different TPs were proposed between the two matrices and cooking treatments, with des-methylated forms and a benzophenone derivative tentatively identified. In chapter 6, NTA was used to study thermal transformation of another veterinary drug, oxytetracycline (OTC), in shrimp. OTC was identified as another commonly detected veterinary drug, particularly in shrimp, thus it was included in this research. The extraction method, based on solvent extraction/freezing, was selected following the same procedure as in Chapter 3. The relevance of using a “spiked” or “water” model to study the fate of OTC during cooking was deemed inadequate, as different TPs were identified between water and incurred/spiked tissues. This research has shown how NTA can be integrated alongside target analysis in both food safety and environmental applications. This type of analysis can describe the chemical “cocktail” to which consumers may be exposed to and it can lead to the discovery of new compounds, i.e., TPs. Through the identifications of these compounds, and evaluation of toxicity, regulatory agencies can better assess possible risks to human health. From an environmental perspective, this research showed how non-target analysis may be used to identify other contaminants present in the environment that may be toxicologically relevant to aquatic species"--
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309030447
Category : Medical
Languages : en
Pages : 393
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Book Description
Author: Claas Kirchhelle
Publisher: Rutgers University Press
ISBN: 0813591473
Category : Medical
Languages : en
Pages : 451
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Book Description
Pyrrhic Progress analyses over half a century of antibiotic use, regulation, and resistance in US and British food production. Mass-introduced after 1945, antibiotics helped revolutionize post-war agriculture. Food producers used antibiotics to prevent and treat disease, protect plants, preserve food, and promote animals' growth. Many soon became dependent on routine antibiotic use to sustain and increase production. The resulting growth of antibiotic infrastructures came at a price. Critics blamed antibiotics for leaving dangerous residues in food, enabling bad animal welfare, and selecting for antimicrobial resistance (AMR) in bacteria, which could no longer be treated with antibiotics. Pyrrhic Progress reconstructs the complicated negotiations that accompanied this process of risk prioritization between consumers, farmers, and regulators on both sides of the Atlantic. Unsurprisingly, solutions differed: while Europeans implemented precautionary antibiotic restrictions to curb AMR, consumer concerns and cost-benefit assessments made US regulators focus on curbing drug residues in food. The result was a growing divergence of antibiotic stewardship and a rise of AMR. Kirchhelle's comprehensive analysis of evolving non-human antibiotic use and the historical complexities of antibiotic stewardship provides important insights for current debates on the global burden of AMR.
