Charcterization of the Midline Axon Guidance Cue Slit and Its Interaction with Robo Receptors in Drosophila Melanogaster PDF Download
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Author: Kimberly Sue Bland
Publisher:
ISBN:
Category :
Languages : en
Pages : 354
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Book Description
Author: Kimberly Sue Bland
Publisher:
ISBN:
Category :
Languages : en
Pages : 354
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Book Description
Author: Julie Hayner Simpson
Publisher:
ISBN:
Category :
Languages : en
Pages : 422
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Book Description
Author: Theresa Wei-Yuan Ho
Publisher:
ISBN:
Category :
Languages : en
Pages : 340
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Author: Christelle Sabatier
Publisher:
ISBN:
Category :
Languages : en
Pages : 406
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Book Description
Author: LaFreda Janae Howard
Publisher:
ISBN:
Category : Nervous system
Languages : en
Pages : 286
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Book Description
In animals with complex nervous systems such as mammals and insects, signaling pathways are responsible for guiding axons to their appropriate synaptic targets. Importantly, when this process is not successful during the development of an organism, outcomes include catastrophes such as human neurological diseases and disorders. It is vital to determine the underlying causes of such diseases by understanding the development of the nervous system. There are many pathways that have been identified to play a role in this, however, we lack an understanding of how these pathways can promote such diverse outcomes in different populations of neurons. These pathways include conserved ligand and receptor complexes that can either synergistically or antagonistically determine the fate of axons. Among these complexes include Slit and Robo, the first ligand and receptor complex to be identified in Drosophila. Previous studies show that disrupting this complex causes ectopic midline crossing of axons in a wide range of animals. Here, to analyze the structural foundation of the diverse activities of Robo2, I examine the relative contributions of its Ig domains by generating transgenic animals expressing variant proteins. I show that Ig domains are not individually required for protein stabilization and localization in vivo. I also use a cell overlay assay to examine the structural and functional importance of all domains of Drosophila Robo2. Deleting the Ig1, Ig5, and Fn2 domains of Robo2 reduce Slit binding in cultured Drosophila cells. The other domains of Robo2 are individually dispensable in Robo2's ability to bind to Slit in vitro.
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 632
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Author: Hans J. ten Donkelaar
Publisher: Springer Science & Business Media
ISBN: 3540346597
Category : Medical
Languages : en
Pages : 544
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Book Description
Progress in developmental neurobiology and advances in (neuro) genetics have been spectacular. The high resolution of modern imaging techniques applicable to developmental disorders of the human brain and spinal cord have created a novel insight into the developmental history of the central nervous system (CNS). This book provides a comprehensive overview of the development of the human CNS in the context of its many developmental disorders. It provides a unique combination of data from human embryology, animal research and developmental neuropathology, and there are more than 400 figures in over a hundred separate illustrations.
Author:
Publisher: Academic Press
ISBN: 0080859429
Category : Science
Languages : en
Pages : 789
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Book Description
Drosophila melanogaster: Practical Uses in Cell and Molecular Biology is a compendium of mostly short technical chapters designed to provide state-of-the art methods to the broad community of cell biologists, and to put molecular and cell biological studies of flies into perspective. The book makes the baroque aspects of genetic nomenclature and procedure accessible to cell biologists. It also contains a wealth of technical information for beginning or advanced Drosophila workers. Chapters, written within a year of publication, make this topical volume a valuable laboratory guide today and an excellent general reference for the future.Key Features* Collection of ready-to-use, state-of-the art methods for modern cell biological and related research using Drosophila melanogaster* Accessible to both experienced Drosophila researchers and to others who wish to join in at the cutting edge of this system * Drosophila offers an easily managed life cycle, inexpensive lifestyle, extraordinarily manipulable molecular and classical genetics, now combined with powerful new cell biology techniques * Introduction and overview sections orient the user to the Drosophila literature and lore * Six full-color plates and over 100 figures and tables enhance the understanding of these cell biology techniques
Author: Gerald M. Edelman
Publisher: Wiley-Interscience
ISBN:
Category : Medical
Languages : en
Pages : 626
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Book Description
This volume addresses central issues in the embryological development of the nervous system, which, while similar to that of other organs and tissues, features special and intricate mechanisms of morphogenesis. It emphasizes the description of cellular interactions at the molecular level and includes some of the first fruits from applications to neurobiology of recent developments in othera areas--notable immunology, biochemistry, molecular biology, and molecular genetics.
Author: Jochen C. Rink
Publisher: Humana
ISBN: 9781493978007
Category : Science
Languages : en
Pages : 0
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Book Description
This volume explores the various facets of planaria as a biomedical model system and discusses techniques used to study the fascinating biology of these animals. The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. Part Two talks about experimental protocols for studying planarians, ranging from the establishment of a planarian research colony, to RNA and DNA extraction techniques, all the way to single stem cell transplantations or metabolomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Planarian Regeneration: Methods and Protocols is a valuable resource for both newcomers to the field and experts within established planarian laboratories.
