Characterization of Channel Catfish (Ictalurus Punctatus) Novel Immune-type Receptors and Monoclonal Antibodies to MHC Class II B PDF Download
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Author: Jason Evenhuis
Publisher:
ISBN:
Category :
Languages : en
Pages : 254
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Author: Jason Evenhuis
Publisher:
ISBN:
Category :
Languages : en
Pages : 254
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Author: Jason P. Evenhuis
Publisher:
ISBN:
Category :
Languages : en
Pages : 254
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Author: Charles M. Heartwell
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ISBN:
Category : Channel catfish
Languages : en
Pages : 44
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Partial antibody characterization indicates that specific channel catfish immunoglobulins are macroglobulins with characteristics like those of most fish immunoglobulins and similar to those of human immunoglobulin-M.
![Characterization of the [beta]-2 Microglobulin Gene in Channel Catfish (Ictalurus Punctatus) PDF](https://books.google.com/books/content/images/frontcover/LcZlNwAACAAJ?fife=w80-h100)
Author: Ralph G. Benedetto
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ISBN:
Category : Channel catfish
Languages : en
Pages : 82
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Author: Michael Flores
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ISBN:
Category : Channel catfish
Languages : en
Pages : 176
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Author: U.S. Fish and Wildlife Service
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Category : Antibodies
Languages : en
Pages : 35
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Partial antibody characterization indicates that specific channel catfish immunoglobulins are macroglobulins with characteristics like those of most fish immunoglobulins and similar to those of human immunoglobulin-M.
![Isolation and Characterization of a Major Histocompatibility Complex Class II [beta] Chain Gene of the Channel Catfish (Ictalurus Punctatus) PDF](https://books.google.com/books/content/images/frontcover/tUOxNwAACAAJ?fife=w80-h100)
Author: Ulla B. Godwin
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ISBN:
Category : Channel catfish
Languages : en
Pages : 132
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Author: Benjamin Christian Sivert Montgomery
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Category : Cell receptors
Languages : en
Pages :
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Author: Herman D. Cortes
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ISBN:
Category : Channel catfish
Languages : en
Pages : 137
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Book Description
In response to pathogens, immune cells induce protective effector functions, such as degranulation, phagocytosis and cytokine secretion, which are initiated by stimulatory or inhibitory immunoregulatory receptors expressed on leukocytes. Using a fish immunological model system, the focus of my thesis work was to examine immunoregulatory receptors in vertebrates by further characterizing members of the teleost Leukocyte Immune-type Receptor (LITR) family. IpLITRs share structural and phylogenetic features with certain mammalian receptors involved in activating and abrogating immune cell functions. As stimulatory IpLITR2.6b associates with signaling adaptor molecule IpFcR[gamma]-L, I expressed a chimeric construct of IpLITR2.6b with IpFcR[gamma]-L in mammalian immune cells to examine its functional abilities. Engagement of this receptor- adaptor induced intracellular signaling and activation of degranulation and phagocytosis. I also expressed IpLITR1.1b, a receptor previously reported to inhibit natural killer cell cytotoxicity to examine its functions further. This inhibitory receptor surprisingly facilitated phagocytosis. This represents dual functionality among select IpLITR-types, which, to our knowledge, has not been reported before in fish. Taken together, these results highlight conserved aspects of immunoregulatory receptor signaling and function while revealing new insights that may contribute to our overall understanding of immunity.
Author: Sevil Erdenlig
Publisher:
ISBN:
Category : Channel catfish
Languages : en
Pages : 220
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