Causes and Consequences of Mild Blast-Induced Traumatic Brain Injury PDF Download
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Author: Nicholas Stephen Race
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: Nicholas Stephen Race
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: Raj K. Narayan
Publisher: McGraw-Hill
ISBN: 9780070456624
Category : Medical
Languages : en
Pages : 1558
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Book Description
This reference is a comprehensive work in the field of neurotrauma and critical care. It incorporates the fields of head injury, spinal injury and basic neurotrauma research into one source. The major emphasis is on the treatment of patients with head and spinal cord injury, including the management of all other problems that bear upon the care of these patients.
Author: Firas H. Kobeissy
Publisher: CRC Press
ISBN: 1466565993
Category : Medical
Languages : en
Pages : 718
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Book Description
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Author: Daniel Laskowitz
Publisher: CRC Press
ISBN: 1498766579
Category : Medical
Languages : en
Pages : 388
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Book Description
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309486890
Category : Medical
Languages : en
Pages : 211
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Book Description
The Veterans Benefits Administration (VBA) provides disability compensation to veterans with a service-connected injury, and to receive disability compensation from the Department of Veterans Affairs (VA), a veteran must submit a claim or have a claim submitted on his or her behalf. Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans reviews the process by which the VA assesses impairments resulting from traumatic brain injury for purposes of awarding disability compensation. This report also provides recommendations for legislative or administrative action for improving the adjudication of veterans' claims seeking entitlement to compensation for all impairments arising from a traumatic brain injury.
Author: Cristina Morganti-Kossmann
Publisher: Cambridge University Press
ISBN: 1107007437
Category : Medical
Languages : en
Pages : 361
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Book Description
Presents the most up-to-date clinical and experimental research in neurotrauma in an illustrated, accessible, comprehensive volume.
Author: Jun Chen
Publisher: Springer Science & Business Media
ISBN: 1603271856
Category : Medical
Languages : en
Pages : 490
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Book Description
Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.
Author: U. S. Military
Publisher:
ISBN: 9781702765015
Category :
Languages : en
Pages : 74
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Book Description
Traumatic Brain Injury (TBI) has become a major health concern in the U.S. Army. Since October 2001, over 2.6 million service members have deployed in support of combat operations, where TBI, primarily caused by blast, has been underreported and underdiagnosed. The Department of Defense (DoD) reports that nearly 384,000 service members serving in the Global War on Terror have suffered a TBI, classifying eighty two percent as mild TBI (mTBI). Labeled an "invisible wound," mTBI has proven difficult to both prevent and diagnose. In addition, blast injuries further complicate mTBI diagnosis, adding to the problem's complexity. In this light, protecting soldiers from blast-induced TBI (bTBI) has attracted attention from the public, senior DoD officials, and the government. The DoD has funded studies to help medical professionals diagnose bTBI and help identify its associated effects in order to treat those injured and return them to service. As the Army races to test and field new equipment to better protect soldiers, diagnosing mTBI, especially those induced by blast, remains a problem for health professionals and the Army at large. Thus, further research is needed that will spark new strategies to help alleviate blast-induced brain injuries and their ramifications in soldier's lives.This compilation also includes a reproduction of the 2019 Worldwide Threat Assessment of the U.S. Intelligence Community.1. Introduction * Background: TBI Defined * Background: History of TBI * Literature Review * Methodology * 2. Department of Defense (DoD) Milestones * Incremental improvements since 2005 * TBI screening * Blast Physics * Neurological Impairments * Mechanism for Blast Transport * Three possible pathways to the brain * Theories of how blast-induced brain damage occurs * Causes include the recoilless rifle * 3. Distinctive bTBI Characteristics * bTBI and Disease Risk * bTBI injuries correlate with incidents of PTSD * Combat MOSs show disproportional rates of mTBI * Blood test helps identify TBI * Prognosis and Recovery * 4. Treatment for TBI * TBI and Long-Term Health or Disability Outcomes * Challenges and Issues * Soldier Protection from Blast * Combat helmet improvements * Development of robotic teammates * 5. Analysis and Recommendations * Analysis * RecommendationsFor hundreds of thousands of soldiers who have served in the U.S. Army since the beginning of the Global War on Terror (GWOT), the likelihood of suffering a Traumatic Brain Injury (TBI) during active duty has changed from a statistical possibility to a personal, often life-changing reality. Since October 2001, over two million service members have deployed in support of combat operations in Iraq, Afghanistan, and Syria; of those, studies show that up to twenty-three percent - or more than 380,000 - have suffered a TBI of some degree or category. As mounting health issues have accompanied service members returning home, concern from soldier's loved ones, the medical community, and U.S. governmental agencies has risen as well. In response, independent study groups, task forces, and a Presidential Commission in 2012 were formed to study the effects of TBI and make recommendations.
Author: Jesus Avila
Publisher: Frontiers E-books
ISBN: 288919261X
Category : Medicine (General)
Languages : en
Pages : 114
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Book Description
Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Author: Alisa D. Gean
Publisher: Lippincott Williams & Wilkins
ISBN: 146988352X
Category : Medical
Languages : en
Pages : 356
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Book Description
Brain Injury: Applications from War and Terrorism is a single-authored book written by a world-class neuroradiologist with extensive experience in traumatic brain injury (TBI). It features six graphic-intense chapters depicting and expounding upon the complexity of TBI. Culled from nearly three decades of studying civilian TBI and five years of intensive study of TBI sustained from combat, terrorism, and natural disasters, this work is an exhaustive and innovative authority on the current approaches and applications of civilian and combat TBI. The text is sectored into six chapters based on pathophysiology, each augmented with numerous images and illustrations. The book gives special attention to neuroimaging, but is reinforced with relevant clinical correlation. This monograph is unique because it is first in class as an omnibus for the radiologist, neurologist, neurosurgeon, maxillofacial surgeon, emergency physician, pediatrician, ophthalmologist, and the rehabilitation team. Accompanied by detailed high resolution illustrations with meticulous annotation, Brain Injury: Applications from War and Terrorism contains over 500 curated radiological and clinical images that enhance the concepts detailed in each chapter. Complete with up-to-date references, it is a state of the art resource guide for any member of the team of professionals caring for those who have sustained a traumatic brain injury In the foreword, Bob Woodruff writes - “After the September 11 attacks, [Dr. Gean] realized the significant void in our understanding of brain Injury caused by war and terrorism (and) she was motivated to devote the last four years of her academic pursuits to understanding the similarities and differences between civilian TBI and TBI suffered in war, terrorism, and natural disasters... This extraordinary, magnificently illustrated and unique single-authored textbook, Brain Injury: Applications from War and Terrorism,is the culmination of Dr. Gean’s dedication and experience. It’s really not just a book – it is a telegraphed documentary of a lifelong conviction to recognizing and responding to TBI by an acknowledged global expert.”
