Author: Alejandro Lopez-Soto
Publisher:
ISBN: 9781493988853
Category : Cancer
Languages : en
Pages : 363

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Book Description

Author: Macfarlane Burnet
Publisher: Elsevier
ISBN: 1483159221
Category : Medical
Languages : en
Pages : 289

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Book Description
Immunological Surveillance

Author: Michele W.L. Teng
Publisher: Elsevier Inc. Chapters
ISBN: 0128059036
Category : Medical
Languages : en
Pages : 684

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Book Description
In 1957 Burnet and Thomas formulated the cancer immunosurveillance theory by hypothesizing that lymphocytes act as sentinels in recognizing and eliminating continuously arising, nascent transformed cells. Cancer immunosurveillance is one of several important host protection processes that inhibit carcinogenesis and maintain regular cellular homeostasis. More recently, it has been proposed that immunosurveillance primarily functions as a component of a more general process of cancer immunoediting, which involves three phases, elimination (surveillance), equilibrium and escape. These stages have largely been formulated on the basis of experimental data accumulated in mice over the past decade. In parallel, convincing correlative clinical data from human patients have provided unequivocal evidence that cells of the immune system, both innate and adaptive, are required for prevention of cancer. This chapter summarizes the principles of cancer immunoediting and focuses on the relevant clinical data that best support the role of immunity in cancer initiation, growth and spread.

Author: Larry W. Moreland
Publisher: Springer Science & Business Media
ISBN: 3540206256
Category : Medical
Languages : en
Pages : 933

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Book Description
Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field

Author: Florencia McAllister
Publisher:
ISBN: 9781071620144
Category : Cancer
Languages : en
Pages : 227

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Book Description
This volume provides methods and techniques to further the study of cancer immunoprevention. Chapters describe tumor-associated antigens, cancer immune-preventive vaccines, generation of TILs, development of monoclonal antibodies, immunoprofiling technologies, tissue multispectral imaging techniques, mass cytometry on suspensions, mutiparametric flow cytometry, genomic expression analysis, and proteomic profiling of tumor microenvironment cell populations and metabolic assessment through novel imaging technologies. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Cancer Immunoprevention: Methods and Protocol aims to further understanding, development of interventional active strategies, and immune-interception of cancer.

Author: Richard T. Smith
Publisher: Elsevier
ISBN: 0323146260
Category : Nature
Languages : en
Pages : 553

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Book Description
Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.

Author: Mansoor M. Amiji
Publisher: Elsevier
ISBN: 0128233974
Category : Business & Economics
Languages : en
Pages : 548

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Book Description
Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Author: Alejandro López-Soto
Publisher: Humana Press
ISBN: 9781493988846
Category : Medical
Languages : en
Pages : 363

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Book Description
This volume explores the latest techniques used to study tumor immunology. The chapters in this book detail methodologies for functional analysis and expansion of T lymphocytes for cancer research. The chapters also cover topics such as how single-cell RNA-sequencing can be exploited to dissect immune cell heterogeneity and precursors; isolating and expanding natural killer (NK) cells; evaluating NK cell-mediated anti-tumor killing activity in vitro; immunosurveillance orchestrated by specific immune subsets; use of HLA peptidomics for cancer-exome based identification of tumor neo-antigens; gold standard assessment of immunogenic cell death in oncological mouse models and methods to look at the therapeutic relevance of immune modulation in cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Cancer Immunosurveillance: Methods and Protocols is a valuable resource to aid researchers in better understanding and experimenting in this exciting and developing field.

Author: Magdalena Klink
Publisher: Springer Nature
ISBN: 3030913112
Category : Medical
Languages : en
Pages : 358

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Book Description
Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.

Author: Stephen J. Withrow
Publisher: Elsevier Health Sciences
ISBN: 0721605583
Category : Medical
Languages : en
Pages : 863

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Book Description
Focusing on cancer in dogs and cats, this extensively updated 4th edition provides comprehensive coverage of the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. Ideal for students, practitioners, and those involved in academic research, this book's full-color images and user-friendly format provide quick and easy access to today's most important information on cancer in the small animal patient. Full-color format throughout and full-color illustrations make information more accessible and provide accurate representations of clinical appearance.Chapters are clustered into four major sections: The Biology and Pathogenesis of Cancer, Diagnostic Procedures for the Cancer Patient, Therapeutic Modalities for the Cancer Patient, and Specific Malignancies in the Small Animal Patient.The consistent format includes incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies in the small animal cancer patient.Features cutting edge information on the complications of cancer, pain management, and the latest treatment modalities. The latest information on the etiology of cancer, including genetic, chemical, physical, and hormonal factors, as well as cancer-causing viruses.Coverage of molecular-targeted therapy of cancer, plus new and emerging therapeutic techniques.New information on molecular diagnostic procedures for the cancer patient.The latest diagnostic imaging techniques in clinical oncology.Discussions of compassion and supportive care, from chronic pain management and nutrition to end-of-life issues and grief support.