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Author: Mylo Sanders
Publisher: American Medical Publishers
ISBN: 9781639276110
Category : Medical
Languages : en
Pages : 0
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Book Description
The process that increases low cytoplasmic concentrations in order to activate specific, essential events required by the cell is defined as calcium signaling. It uses calcium ions (Ca2+) to communicate and carry out intracellular processes often as a step in signal transduction. Calcium signaling plays a crucial role in the regulation of a diverse set of essential functions within the human body. The management of various neurodegenerative disorders such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD) requires calcium signaling. It has been observed that disruption in calcium signaling may lead to synaptic deficits which further leads to accumulation of Aβ plaques and neurofibrillary tangles. Calcium plays an important role in various biological processes and calcium signaling has been linked to various diseases. Therefore, it is currently being explored as a therapeutic target for various types of cancer. This book elucidates the concepts and innovative models around prospective developments with respect to the importance of calcium signaling in biology and medicine. It will serve as a valuable source of reference for those interested in this field of study.
Author: Mylo Sanders
Publisher: American Medical Publishers
ISBN: 9781639276110
Category : Medical
Languages : en
Pages : 0
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Book Description
The process that increases low cytoplasmic concentrations in order to activate specific, essential events required by the cell is defined as calcium signaling. It uses calcium ions (Ca2+) to communicate and carry out intracellular processes often as a step in signal transduction. Calcium signaling plays a crucial role in the regulation of a diverse set of essential functions within the human body. The management of various neurodegenerative disorders such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD) requires calcium signaling. It has been observed that disruption in calcium signaling may lead to synaptic deficits which further leads to accumulation of Aβ plaques and neurofibrillary tangles. Calcium plays an important role in various biological processes and calcium signaling has been linked to various diseases. Therefore, it is currently being explored as a therapeutic target for various types of cancer. This book elucidates the concepts and innovative models around prospective developments with respect to the importance of calcium signaling in biology and medicine. It will serve as a valuable source of reference for those interested in this field of study.
Author: Md. Shahidul Islam
Publisher: Springer Science & Business Media
ISBN: 9400728883
Category : Medical
Languages : en
Pages : 1254
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Book Description
Calcium signaling contains a unique selection of chapters that cover a wide range of contemporary topics in this ubiquitous and diverse system of cell signaling. This book has the flavor of a primary text book, but it is much more than that. It covers topics ranging from the fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It discusses cutting edge researches, and critical issues at depth, and it presents many testable hypotheses for future research. It includes the theoretical and the methodological topics as well as topics related to mathematical modeling, and simulations. If you want to read about calcium signaling in different mammalian cells, oocytes, Zebrafishes, and even in plants, in one and the same book, then this book will not disappoint you. From the beginners to the experts in the field of calcium signaling, everybody will find something useful in this very timely book.
Author: R. Pochet
Publisher: Springer Science & Business Media
ISBN: 9401006881
Category : Medical
Languages : en
Pages : 746
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Book Description
The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.
Author: Lars Kaestner
Publisher: Springer Science & Business Media
ISBN: 3642346170
Category : Medical
Languages : en
Pages : 247
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Book Description
The book combines general concepts and methods to investigate calcium signalling in cells ranging from molecular biology approaches to manipulation of calcium in living cells. The focus within these methods in on the broad range of fluorescence imaging technology, in particular on optical sectioning techniques and fast image acquisition. In addition to these general guidelines there are application examples in a context beyond calcium signalling in two major fields: investigations of isolated cardiac myocytes and red blood cell related research. While the cellular cardiology section provides snapshots of certain calcium signalling aspects, the red blood cell part presents an overview from the functional identification of calcium-channels to a concept of physiological and pathophysiological relevance.
Author: Ernesto Carafoli
Publisher: Springer Science & Business Media
ISBN: 1402061919
Category : Medical
Languages : en
Pages : 591
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Book Description
Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
Author: Geert Bultynck
Publisher:
ISBN: 9781621823889
Category : Calcium
Languages : en
Pages :
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Book Description
"Calcium ions play a critical role in signaling in a wide variety of cells and tissues, including muscle, immune cells, neurons, the liver, and oocytes. This new volume explores the channels and pumps that transport calcium, calcium buffers and sensors, and how these produce distinct spatiotemporal signals in different circumstances. It covers calcium signaling during development and normal physiology, as well as perturbed signaling in diseases such as diabetes, neurodegeneration, and atherosclerosis"--
Author: Francesco Moccia
Publisher: MDPI
ISBN: 3038975370
Category : Biochemistry
Languages : en
Pages : 463
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Book Description
This book is a printed edition of the Special Issue "Calcium Signaling in Human Health and Diseases" that was published in IJMS
Author: Senthilkumar Rajagopal
Publisher: Springer
ISBN: 9811051607
Category : Science
Languages : en
Pages : 91
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Book Description
This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important, given the wide variety of cellular processes that are controlled by calcium ions – and provides a trustworthy source of up-to-date information in this area of research.
Author: Stephen W. Schaffer
Publisher: Springer
ISBN: 3709114136
Category : Science
Languages : en
Pages : 158
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Book Description
T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.
Author: Ernesto Carafoli
Publisher: Oxford University Press, USA
ISBN: 9780195094213
Category : Calcium
Languages : en
Pages : 664
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Book Description
Encompassing all aspects of calcium signalling, from methods of measuring calcium in cells to the molecular mechanisms for decoding its information, this comprehensive book balances historical aspects and state of the art developments.
