BTG1, a Novel Mediator of Chemosensitivity in Breast Cancer PDF Download
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Languages : en
Pages : 23
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Book Description
The anti-apoptotic protein Bcl-2 is overexpressed in a majority of breast cancers, and is associated with a diminished apoptotic response and resistance to various anti-tumor agents. Bcl-2 inhibition is currently being explored as a possible strategy for sensitizing breast cancer cells to standard chemotherapeutic agents. Antisense (AS) Bcl-2 oligonucleotides represent one method for blocking the anti-apoptotic effects of Bcl-2. In this study we demonstrate that AS Bcl-2 efficiently blocks Bcl-2 expression, resulting in apoptosis of breast cancer cells. AS Bcl-2-mediated cytotoxicity was associated with induction of the B-cell translocation gene 1 (BTG1). Importantly, knockdown of BTG1 reduced AS Bcl-2-mediated cytotoxicity in breast cancer cells. Further, BTG1 expression appears to be negatively regulated by Bcl-2, and exogenous expression of BTG1 induced apoptosis. These results suggest that BTG1 is a Bcl-2-regulated mediator of apoptosis in breast cancer cells, and that its induction contributes to AS Bcl-2-mediated cytotoxic effects.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 23
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Book Description
The anti-apoptotic protein Bcl-2 is overexpressed in a majority of breast cancers, and is associated with a diminished apoptotic response and resistance to various anti-tumor agents. Bcl-2 inhibition is currently being explored as a possible strategy for sensitizing breast cancer cells to standard chemotherapeutic agents. Antisense (AS) Bcl-2 oligonucleotides represent one method for blocking the anti-apoptotic effects of Bcl-2. In this study we demonstrate that AS Bcl-2 efficiently blocks Bcl-2 expression, resulting in apoptosis of breast cancer cells. AS Bcl-2-mediated cytotoxicity was associated with induction of the B-cell translocation gene 1 (BTG1). Importantly, knockdown of BTG1 reduced AS Bcl-2-mediated cytotoxicity in breast cancer cells. Further, BTG1 expression appears to be negatively regulated by Bcl-2, and exogenous expression of BTG1 induced apoptosis. These results suggest that BTG1 is a Bcl-2-regulated mediator of apoptosis in breast cancer cells, and that its induction contributes to AS Bcl-2-mediated cytotoxic effects.
Author: Sujit Kumar Bhutia
Publisher: Springer Nature
ISBN: 9811569304
Category : Medical
Languages : en
Pages : 284
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Book Description
This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
Author: Afshin Amini
Publisher: Springer
ISBN: 331928570X
Category : Medical
Languages : en
Pages : 246
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Book Description
This volume will describe both growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine, on their own or in combination, in cancer. It will coherently review the pathophysiological aspects of the mucin glycoproteins in malignancies and provide an updated account of the status of bromelain and N-acetylcysteine in cancer therapy. The volume will develop the idea of using these two drugs as a combination formulation for mucin-depleting effects.
Author: Sheikh Rayees
Publisher: Springer Nature
ISBN: 9811537348
Category : Medical
Languages : en
Pages : 184
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Book Description
Chronic lung diseases: pathophysiology and therapeutics provides a much-needed reference tool for pathologists, practicing pulmonologists and researchers who are currently working on lung related diseases. Each chapter addresses a specific lung disease, which it introduces before turning to the disease’s pathophysiology, current treatment and future prospects. Various key lung diseases are covered, including chronic obstructive pulmonary disease, lung cancer, tuberculosis, chronic pneumonia, acute respiratory distress syndrome, asthma, cystic fibrosis and pulmonary hypertension. Medical students and researchers whose work involves pulmonary related disorders will find this work both instructive and informative.
Author: Edward K. L. Chan
Publisher: Springer
ISBN: 9781493902514
Category : Medical
Languages : en
Pages : 0
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Book Description
GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan’s group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.
Author: Chi Hin Cho
Publisher: Academic Press
ISBN: 0128199377
Category : Science
Languages : en
Pages : 240
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Book Description
Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view
Author: Michael J. Myers
Publisher: CRC Press
ISBN: 9780824794354
Category : Nature
Languages : en
Pages : 486
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Book Description
This work offers comprehensive, up-to-date coverage of cytokine biology in veterinary and agricultural species, describing the role of cytokines in physiological and pathological processes. It addresses recent advances and new information on the function of cytokines in reproduction, detoxification of xenobiotics, growth modulation and other areas, and discusses the approaches to and pitfalls of studying cytokines in animals.
Author: Bibekanand Mallick
Publisher: Academic Press
ISBN: 9780128156698
Category : Science
Languages : en
Pages : 0
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Book Description
The 'RNA world' hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world's leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases.
Author: Timothy E. Quill
Publisher: Oxford University Press, USA
ISBN: 0199316678
Category : Medical
Languages : en
Pages : 322
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Book Description
The practice of palliative care and hospice is filled with overt and sometimes covert ethical challenges. These challenges are addressed by leading international palliative care and hospice scholars under three main domains: care delivery systems; addressing the many dimensions of suffering; and difficult decisions near the end of life.
Author: Aung Naing
Publisher: Springer Nature
ISBN: 3030793087
Category : Medical
Languages : en
Pages : 445
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Book Description
The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy.
