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Author: Dihua Yu
Publisher: Springer Science & Business Media
ISBN: 0387740392
Category : Medical
Languages : en
Pages : 175
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Book Description
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.
Author: Dihua Yu
Publisher: Springer Science & Business Media
ISBN: 0387740392
Category : Medical
Languages : en
Pages : 175
Get Book
Book Description
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.
Author: Uwe Reinhold
Publisher: Springer Science & Business Media
ISBN: 9783540434689
Category : Medical
Languages : en
Pages : 262
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Book Description
Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.
Author: Ossi R. Köchli
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Breast
Languages : en
Pages : 218
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Book Description
'It will form an important addition to a scientific library and a useful addition to the (contributions series) which should be part of any obstetrics and gynaecology library.' New Zealand Journal of Obstetrics and Gynaecology
Author: Uwe Reinhold
Publisher: Springer Science & Business Media
ISBN: 3642190227
Category : Medical
Languages : en
Pages : 262
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Book Description
Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.
Author: Diana Warren
Publisher: iUniverse
ISBN: 149174426X
Category : Medical
Languages : en
Pages : 163
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Book Description
Internationally acclaimed integrative medical oncologist James W. Forsythe, M.D., H.M.D., has praised Diana Warren for courage and tenacity in her arduous battle against Stage II breast cancer. Doctor Forsythe insists that "Diana deserves kudos from people around the world, for refusing to subject her body to unnecessary standard chemo and radiation that unscrupulous allopathic oncologists kept trying to require her to endure." Featured in many hot-selling books written by others including media personality Suzanne Somers, and also the author of many successful books himself, Doctor Forsythe has hailed Diana for her dogged determination amid a non-stop quest to find effective natural, non-toxic treatments as her health deteriorated, while also hunting for an experienced doctor licensed to avoid high-dose poisonous options. "I strongly recommend that everyone who suffers from cancer read Diana's compelling tale," Doctor Forsythe said. "Today, Diana is playing a formidable role in helping to lead the way as a true champion in a quest to inform the public of the urgent need to avoid toxic treatments when feasible in certain circumstances, and how to find acceptable natural remedies-plus the importance of avoiding 'standard-of-care' chemo and radiation when under the care and guidance of a qualified, licensed medical professional." After reading many hundreds of books on cancer, Doctor Forsythe hails Diana's publication as being "by far among the best from the viewpoint of a person who never attended medical school. Readers undoubtedly will benefit when learning of the exceptional example Diana has set for us all."
Author: Rosalyn D. Blumenthal
Publisher: Springer Science & Business Media
ISBN: 1592598692
Category : Medical
Languages : en
Pages : 234
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Book Description
A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity, Volume 1: In Vitro Assays provides a panel of 16 in vitro measures of chemosensitivity in adherent and non-adherent cells for single agents and combinations of agents. In addition to immunohistochemical and imaging approaches, these assays include clonogenic, colorimetric, fluorometric, and physiological assays. Highlights include image analysis to assess drug sensitivity, high throughput approaches using green fluorescent protein, DIMSCAN (a microcomputer fluorescence-based assay), and the ChemoFx assay used in biotechnology. A companion volume, Volume 2: In Vivo Models, Imaging, and Molecular Regulators, provides protocols for classifying tumors into response categories and customizing chemotherapy regimens to individual patients.
Author: I. Craig Henderson
Publisher: Springer Science & Business Media
ISBN: 1461534968
Category : Medical
Languages : en
Pages : 462
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Book Description
The results of randomized trials evaluating the use of early or adjuvant systemic treatment for patients with resectable breast cancer provide an eloquent rebuttal to those who would argue that we have made no progress in the treatment of cancer. Many of the tumors that we have been most successful in curing with chemotherapy and other newer forms of treatment are relatively uncommon. In contrast, breast cancer continues to be the single most common malignancy among women in the western world, is increasingly a cause of death throughout Asia and Third-World countries, and remains one of the most substantial causes of cancer mortality world wide. The use of mammography as a means of early detection has been shown to reduce breast cancer mortality by 25-35% among those popu lations in which it is utilized. The use of adjuvant systemic treatment in appropriate patients provides a similar (and additional) reduction in breast cancer mortality. Few subjects have been so systematically studied in the history of medicine, and it seems fair to conclude that the value to adjuvant systemic therapy in prolonging the lives of women with breast cancer is more firmly supported by empirical evidence than even the more conventional or primary treatments using various combinations ofsurgery and radiotherapy.
Author: Emily K. Abel
Publisher: NYU Press
ISBN: 0814707351
Category : Health & Fitness
Languages : en
Pages : 196
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Book Description
From the book jacket: Chemo Brain. Fatigue. Chronic Pain. Insomnia. Depression. These are just a few of the ongoing, debilitating symptoms that plague some breast cancer survivors long after their treatments have officially ended. After The Cure is a compelling read filled with fascinating portraits of women who are living with the aftermath of breast cancer. Having heard repeatedly that the problems are all in your head, many don't know where to turn for help. The doctors who now refuse to validate their symptoms are often the very ones they depended on to provide life-saving treatments. Sometimes family members, who provided essential support through months of chemotherapy and radiation, don't believe them. Their work lives, already disrupted by both cancer and its treatment, are further undermined by the lingering symptoms. And every symptom is a constant reminder of the trauma of diagnosis, the ordeal of treatment, and the specter of recurrence. Most narratives about surviving breast cancer end with the conclusion of chemotherapy and radiation, painting stereotypical portraits of triumphantly healthy survivors, women who not only survive but emerge better and stronger than before. After The Cure allows us to hear the voices of those who are silenced by the optimistic breast cancer culture, women who live with a broad array of health problems long after therapy ends. Here, at last, survivors step out of the shadows and speak compellingly about their real stories, giving voice to the complicated, often bittersweet realities of life after the cure.
Author: Delthia Ricks
Publisher: Turner Publishing Company
ISBN: 0897935608
Category : Health & Fitness
Languages : en
Pages : 439
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Book Description
For most women and their families, a diagnosis of breast cancer is both devastating and confusing. Questions about the disease -- its cause, treatment, and prognosis -- can be overwhelming at such a difficult time. By gathering together all the latest information available on the subject, this book helps women better understand their illness and enables them to make knowledgeable choices about their care. Among topics discussed are the pros and cons of different treatments including surgery, chemotherapy, radiation, and hormone therapy; breast reconstruction; recurrence rates; building a support team; follow-up care; and life after cancer. The book also explores current issues such as emerging therapies and examines possible links with obesity, ethnicity, and environmental factors. Top breast cancer specialists and researchers offer comments and testimony, and personal stories from breast cancer survivors provide heartening reminders that the reader is not alone. This is a serious breast cancer book for the woman or professional who wants to know all of the latest information from a reliable source.
Author: William J. Gradishar
Publisher: Springer Science & Business Media
ISBN: 9780792378907
Category : Medical
Languages : en
Pages : 230
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Book Description
The optimal management of breast cancer patients relies on the expertise of a team of medical specialists including radiologists, surgeons, radiation therapists and medical oncologists. Much of the progress in breast cancer management made over the last several years reflects the translation of observations made in the laboratory to the clinic. Critically evaluating the impact of new treatment approaches relies on a commitment to well-designed clinical trials. In this volume, Advances in Breast Cancer Management, a renowned group of breast cancer experts have been asked to provide their perspective on management issues that directly effect patients on a day-to-day basis. Dr. Melody Cobleigh discusses the consequences of estrogen deprivation and the ways of ameliorating secondary symptoms and the potential long-term morbidity. Drs. Haigh and Guiliano review the sentinel lymph node biopsy technique including results from their extensive experience. Dr. Abram Recht places into perspective the potential benefit of post-mastectomy radiotherapy and reviews recent trials that address this issue. Dr. Dennis Slamon takes from us from the laboratory to the clinic in explaining the development of Herceptin as a paradigm for therapy targeted to specific molecular characteristics of breast cancer tumor cells. Drs. Nieto, Shpall, Crump and Pritchard offer different perspectives on the future of high-dose chemotherapy with stem cell transplantation as a treatment for breast cancer patients. Drs.
