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Author: Sahil S. Shah
Publisher:
ISBN:
Category : Biosensors
Languages : en
Pages : 75
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Book Description
Analysing and measuring of biological or biochemical processes are of utmost importance for medical, biological and biotechnological applications. Point of care diagnostic system, composing of biosensors, have promising applications for providing cheap, accurate and portable diagnosis. Owing to these expanding medical applications and advances made by semiconductor industry biosensors have seen a tremendous growth in the past few decades. Also emergence of microfluidics and non-invasive biosensing applications are other marker propellers. Analyzing biological signals using transducers is difficult due to the challenges in interfacing an electronic system to the biological environment. Detection limit, detection time, dynamic range, specificity to the analyte, sensitivity and reliability of these devices are some of the challenges in developing and integrating these devices. Significant amount of research in the field of biosensors has been focused on improving the design, fabrication process and their integration with microfluidics to address these challenges. This work presents new techniques, design and systems to improve the interface between the electronic system and the biological environment. This dissertation uses CMOS circuit design to improve the reliability of these devices. Also this work addresses the challenges in designing the electronic system used for processing the output of the transducer, which converts biological signal into electronic signal.
Author: Sahil S. Shah
Publisher:
ISBN:
Category : Biosensors
Languages : en
Pages : 75
Get Book Here
Book Description
Analysing and measuring of biological or biochemical processes are of utmost importance for medical, biological and biotechnological applications. Point of care diagnostic system, composing of biosensors, have promising applications for providing cheap, accurate and portable diagnosis. Owing to these expanding medical applications and advances made by semiconductor industry biosensors have seen a tremendous growth in the past few decades. Also emergence of microfluidics and non-invasive biosensing applications are other marker propellers. Analyzing biological signals using transducers is difficult due to the challenges in interfacing an electronic system to the biological environment. Detection limit, detection time, dynamic range, specificity to the analyte, sensitivity and reliability of these devices are some of the challenges in developing and integrating these devices. Significant amount of research in the field of biosensors has been focused on improving the design, fabrication process and their integration with microfluidics to address these challenges. This work presents new techniques, design and systems to improve the interface between the electronic system and the biological environment. This dissertation uses CMOS circuit design to improve the reliability of these devices. Also this work addresses the challenges in designing the electronic system used for processing the output of the transducer, which converts biological signal into electronic signal.
Author: Sandro Carrara
Publisher: Springer Nature
ISBN: 3031318323
Category : Technology & Engineering
Languages : en
Pages : 530
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Book Description
This textbook demonstrates new paradigms for the interface between CMOS circuits and the biological world. A deep theoretical description of such an interface is defined and discussed, while various real applications are demonstrated by also discussing several analog CMOS circuits. Electrochemical techniques are proposed in detail to learn how to design integrated biosensors. Biological materials are described to provide devices selectivity. Nanoscale materials are discussed to provide device sensitivity. CMOS circuits are analyzed to provide real applications. Extensive examples with solutions are provided, as well as exercises at the end of each chapter. This book introduces students to the state-of-the-art in Bio/CMOS interfaces, describing leading-edge research in CMOS design and VLSI development for applications requiring intimate integration of biological molecules onto the chip. It provides multidisciplinary content ranging from biochemistry to CMOS design in order to address Bio/CMOS interface co-design in biosensing applications.
Author: Ebrahim Ghafar-Zadeh
Publisher: Springer Science & Business Media
ISBN: 9048137276
Category : Technology & Engineering
Languages : en
Pages : 154
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Book Description
1.1 Overview of Lab-on-Chip Laboratory-on-Chip (LoC) is a multidisciplinary approach used for the miniaturization, integration and automation of biological assays or procedures in analytical chemistry [1–3]. Biology and chemistry are experimental sciences that are continuing to evolve and develop new protocols. Each protocol offers step-by-step laboratory instructions, lists of the necessary equipments and required biological and/or chemical substances [4–7]. A biological or chemical laboratory contains various pieces of equipment used for performing such protocols and, as shown in Fig. 1.1, the engineering aspect of LoC design is aiming to embed all these components in a single chip for single-purpose applications. 1.1.1 Main Objectives of LoC Systems Several clear advantages of this technology over conventional approaches, including portability, full automation, ease of operation, low sample consumption and fast assays time, make LoC suitable for many applications including. 1.1.1.1 Highly Throughput Screening To conduct an experiment, a researcher fills a well with the required biological or chemical analytes and keeps the sample in an incubator for some time to allowing the sample to react properly. Afterwards, any changes can be observed using a microscope. In order to quickly conduct millions of biochemical or pharmacolo- cal tests, the researchers will require an automated highly throughput screening (HTS) [8], comprised of a large array of wells, liquid handling devices (e.g., mic- channel, micropump and microvalves [9–11]), a fully controllable incubator and an integrated sensor array, along with the appropriate readout system.
Author: Srinjoy Mitra
Publisher: Springer
ISBN: 3319677233
Category : Technology & Engineering
Languages : en
Pages : 354
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Book Description
This book provides the most comprehensive and consistent survey of the field of IC design for Biological Sensing and Processing. The authors describe a multitude of applications that require custom CMOS IC design and highlight the techniques in analog and mixed-signal circuit design that potentially can cross boundaries and benefit the very wide community of bio-medical engineers.
Author: Krzysztof Iniewski
Publisher: John Wiley & Sons
ISBN: 1118016483
Category : Technology & Engineering
Languages : en
Pages : 425
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Book Description
The book will address the-state-of-the-art in integrated Bio-Microsystems that integrate microelectronics with fluidics, photonics, and mechanics. New exciting opportunities in emerging applications that will take system performance beyond offered by traditional CMOS based circuits are discussed in detail. The book is a must for anyone serious about microelectronics integration possibilities for future technologies. The book is written by top notch international experts in industry and academia. The intended audience is practicing engineers with electronics background that want to learn about integrated microsystems. The book will be also used as a recommended reading and supplementary material in graduate course curriculum.
Author: Eugenio Culurciello
Publisher: McGraw Hill Professional
ISBN: 0071608494
Category : Technology & Engineering
Languages : en
Pages : 413
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Book Description
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The Latest Silicon-on-Sapphire CMOS Design and Fabrication Techniques Develop high-performance SOS-based microsystems. Filled with examples, schematics, and charts, Silicon-on-Sapphire Circuits and Systems covers the latest analog and mixed-signal IC design techniques. Learn how to assemble SOI/SOS circuits and systems, work with an insulated substrate and device models, create miniaturized amplifiers and switches, and build ADCs and DACs. You will also find information on constructing photosensitive circuits and memory chips, deploying integrated biosensors, overcoming noise and power issues, and maximizing efficiency. Discover how to: Extract active and passive device models and parameters Design single-stage amplifiers, op amps, references, and comparators Build digital processors, data converters, and mixed-mode circuits Deploy photodetectors in active pixel sensor and imaging arrays Optimize performance, quantum efficiency, and signal-to-noise ratio Develop current and voltage mode SOS-based biosensors Use CMOS, monolithic, and digital phase-shift isolation techniques Integrate the latest three-dimensional assemblies and die packages
Author: M Lambrechts
Publisher: CRC Press
ISBN: 1000447839
Category : Science
Languages : en
Pages : 326
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Book Description
Biosensors are analytical devices that combine a biologically sensitive element with a physical or chemical transducer to selectively and quantitatively detect the presence of specific compounds. Balancing basics, principles, and case studies, Biosensors: Microelectrochemical Devices covers the theory and applications of one class of biosensor-microelectrochemical devices. The book clearly explains microelectronic techniques used to produce these cheap, fast reacting, and disposable sensors with the aid of helpful diagrams and tables. Researchers and postgraduates active in the field of chemical sensors, analytical chemistry, or microelectronics will find this an invaluable reference.
Author: Dr. Abdullah Tashtoush
Publisher: Xlibris Corporation
ISBN: 1483646025
Category : Medical
Languages : en
Pages : 292
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Book Description
About the Book The book includes a variety of techniques that are conducting biosensors as transducers. The single die has all of the biosensors implemented within it, which leads to a new generation of multibiosensors named as multi-labs-on-a-single chip (MLoC). Biosensors are analytical devices that combine a biologically sensitive element with a physical or chemical transducer to detect the presence of specific compounds selectively and quantitatively. This book explores the feasibility of microelectronic techniques in a successful attempt to get huge cost savings in mass production, fast reacting, and disposable biosensors. The book is lied in six chapters and four appendices. These sensors were implemented using CMOSP35 technology on a single-chip that covers new techniques for detecting biomedical and biological samples at low concentration level based on CMOS/MEMS technology batch process. The methodology of the proposed multibiosensors that is named by multi-lab-on-a-chip (MLoC); lies on miniaturizing transducers, which is based on optical CMOS technology, charge based capacitance measurements (CBCM), electrochemical impedance spectroscopy (EIS) and CMOS microcoils incorporating with interdigitated microelectrode array (IDMA). The aforementioned approaches technically proved their capability and reliability overwhelmingly among the used conventional techniques for that reason these techniques have been proposed to create compact and portable biosensors for sensitive and rapid detection of biomedical and biological samples. While the four proposed biosensors have common objectives they differ in the method and analysis used, and postulates engaged by a discipline to achieve the objectives; the inquiry of the principles of investigation in a particular field.
Author: Sandro Carrara
Publisher: Springer Science & Business Media
ISBN: 1461446902
Category : Technology & Engineering
Languages : en
Pages : 266
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Book Description
The application of CMOS circuits and ASIC VLSI systems to problems in medicine and system biology has led to the emergence of Bio/CMOS Interfaces and Co-Design as an exciting and rapidly growing area of research. The mutual inter-relationships between VLSI-CMOS design and the biophysics of molecules interfacing with silicon and/or onto metals has led to the emergence of the interdisciplinary engineering approach to Bio/CMOS interfaces. This new approach, facilitated by 3D circuit design and nanotechnology, has resulted in new concepts and applications for VLSI systems in the bio-world. This book offers an invaluable reference to the state-of-the-art in Bio/CMOS interfaces. It describes leading-edge research in the field of CMOS design and VLSI development for applications requiring integration of biological molecules onto the chip. It provides multidisciplinary content ranging from biochemistry to CMOS design in order to address Bio/CMOS interface co-design in bio-sensing applications.
Author: Jordi Colomer-Farrarons
Publisher: Springer Science & Business Media
ISBN: 9400706863
Category : Technology & Engineering
Languages : en
Pages : 169
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Book Description
A CMOS Self-Powered Front-End Architecture for Subcutaneous Event-Detector Devices presents the conception and prototype realization of a Self-Powered architecture for subcutaneous detector devices. The architecture is designed to work as a true/false (event detector) or threshold level alarm of some substances, ions, etc... that are detected through a three-electrodes amperometric BioSensor approach. The device is envisaged as a Low-Power subcutaneous implantable application powered by an inductive link, one emitter antenna at the external side of the skin and the receiver antenna under the skin. The sensor is controlled with a Potentiostat circuit and then, a post-processing unit detects the desired levels and activates the transmission via a backscattering method by the inductive link. All the instrumentation, except the power module, is implemented in the so called BioChip. Following the idea of the powering link to harvest energy of the magnetic induced link at the implanted device, a Multi-Harvesting Power Chip (MHPC) has been also designed.
