Author: Jan Ježek
Publisher: Springer
ISBN: 3319639536
Category : Science
Languages : en
Pages : 243
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Book Description
This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
Author:
Publisher: Academic Press
ISBN: 0128174749
Category : Science
Languages : en
Pages : 440
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Book Description
Advances in Heterocyclic Chemistry, Volume 129 is the definitive series in the field—one of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive, updated release includes chapters on Metal-Catalyzed Direct Arylation of 1,2-Azoles, The Literature of Heterocyclic Chemistry, Part XVII, 2017, Pyrrolo-, Imidazoquinolines and Pyrroloquinazolines with a Bridgehead Nitrogen, Synthesis and Reactions of Arsole, Stibole, and Bismole, Advances in Synthesis and Chemistry of Aziridines, and more. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds
Author: Nadine Millot
Publisher: MDPI
ISBN: 3039285424
Category : Medical
Languages : en
Pages : 366
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Book Description
This book provides an overview of the design and physico-chemical properties of nanoparticles developed for biomedical applications such as targeting and detection of pathologies, nanovectorization of drugs, radiosensitization, metal detection, and nanocomposite implants. The considerations necessary when developing a new nanomedicine are also developed, including toxicological investigation, biodistribution, and efficacy. This book provides an accurate and current representation of the field by addressing the promises and hurdles of nanomedicine via 20 different pertinent studies. Covering a wide range of areas, this book is an excellent partner for physico-chemists, doctors, pharmacologists, and biochemists working on nanosciences dedicated to medicine, both in industry and in academia.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1364
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Book Description
Author: R. J. H. Clark
Publisher: John Wiley & Sons
ISBN:
Category : Science
Languages : en
Pages : 416
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Book Description
About this book In recent years, a number of different spectroscopic techniques have been applied to the study of a wide range of biomedical topics. Biomedical investigations in fields as diverse as eye lens research, the study of cardiovascular and inflammatory diseases, and the study of oxidative stress in disease can now be carried out by spectroscopic means. The nine chapters in Biomedical Applications of Spectroscopy present an authoritative overview of the current status of the field, with each chapter written by acknowledged experts. A wide range of techniques is considered, including optical microspectroscopy, Raman spectroscopy, FTIR spectroscopy, NMR and EPR spectroscopy and mass spectrometry. This highly topical volume will stimulate interest in this expanding field, and point the way towards future directions in research. The major objectives of this established series are to integrate theory and practice and to bring together different branches of both academic and industrial research through the presentation of critical review articles in fundamental and applied spectroscopy. The policy of the editors is to commission authoritative reviews by acknowledged leaders in the various fields of spectroscopy. Thus each volume presents a carefully composed picture of the state of the art for a particular area. For each volume the subject matter is presented in a manner which is Comprehensible to the non-expert, for whom the series will continue to provide a valuable introduction, and a timely overview of topics in spectroscopy which are of current interest and importance. At the same time the involved expert will find much to engage his or her attention. The series is of interest to research scientists and technologists, to teachers and both graduate and undergraduate students.
Author: Robert Christie
Publisher: Royal Society of Chemistry
ISBN: 1847550592
Category : Science
Languages : en
Pages : 218
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Book Description
This book provides an up-to-date insight into the chemistry behind the colour of the dyes and pigments that make our world so colourful. The impressive breadth of coverage starts with a dip into the history of colour science. Colour Chemistry then goes on to look at the structure and synthesis of the various dyes and pigments, along with their applications in the traditional areas of textiles, coatings and plastics, and also the ever-expanding range of "high-tech" applications. Also discussed are some of the environmental issues associated with the manufacture and use of colour. The broad and balanced coverage presented in this book makes it ideal for students and graduates. In addition, many specialists in industry or academia will also benefit from the overview of the subject that is provided.
Author: Prashant Kesharwani
Publisher: Academic Press
ISBN: 0128212519
Category : Medical
Languages : en
Pages : 486
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Book Description
Dendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have given rise to multifunctional smart nanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, including intracellular organelle-specific targeting. This book compiles the contribution of dendrimers in the field of nanotechnology to aid researchers in exploring dendrimers in the field of drug delivery and related applications. This book covers the history of the area to the most recent research. The starting chapter covers detailed information about basic properties about dendrimers i.e. properties, nomenclature, synthesis methods, types, characterization of dendrimers, safety and toxicity issues of dendrimers. Further chapters discuss the most recent advancements in the field of dendrimer i.e. dendrimer-drug conjugates, PEGylated dendrimer, dendrimer surface engineering, dendrimer hybrids, dendrimers as solubility enhancement, in targeting and delivery of drugs, as photodynamic therapy, in tissue engineering, as imaging contrast agents, as antimicrobial agents, advances in targeted dendrimers for cancer therapy and future considerations of dendrimers. Dendrimer-Based Nanotherapeutics will help the readers to understand the most recent progress in the field of dendrimer-based research, suitable for pharmaceutical scientists, advanced students, and those working in related healthcare fields. - Discusses various routes such as oral, pulmonary, transdermal, delivery and local administration of dendrimer delivery of bioactive - Explores a wide range of applications of dendrimer-based drug delivery using the latest advancements in nanomedicine - Provides the most recent research on dendrimers as well as context and background, providing a useful resource for all levels of researcher
Author: H.S. Freeman
Publisher: Elsevier
ISBN: 0080529380
Category : Technology & Engineering
Languages : en
Pages : 637
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Book Description
This volume examines the chemistry of natural and synthetic dyes produced for non-textile markets, where much new basic research in color chemistry is now taking place.The first group of chapters covers the design, synthesis, properties and application technology pertaining to dyes for digital printing and photography. The reader will be pleased with the breadth and depth of information presented in each case. Of particular interest is the discussion of strategies for the design of dyes in these categories, with emphasis on enhancing technical properties. In view of certain new developments, the ink-jet chapter includes results from studies pertaining to dyes for textiles.The three chapters comprising Section II of this volume cover the broad subject of dyes for food, drug and cosmetic applications and then provide an in-depth look at dyes for biomedical applications and molecular recognition. The chapter on dyes for molecular recognition places emphasis on applications in the biological sciences, including sensory materials and artificial receptors. While the former two topics have been covered elsewhere in the past, the present chapters are unequalled in scope.Section III provides an in-depth review of the design of laser dyes and dye-based functional materials. In the first of the two chapters, the major principles of laser operation are summarized. This is followed by a discussion of spectroscopic properties, such as activation and deactivation of absorbed light by laser dyes. Approaches to the development of new laser dyes are presented. The second chapter pertains to the synthesis of dicyanopyrazine-based multifunctional dyes. The visible and fluorescence spectra of these dyes in solution and the solid state are correlated with their three-dimensional molecular structures. Molecular stacking behavior and solid state properties of these "multifunctional" dye materials are presented.The final group of chapters pertains to natural dyes and dyes for natural substrates. In recent years, the impression among certain consumers that "natural" is better/safer has generated much interest in the use of natural dyes rather than synthetics. This has led to a few short discussion papers in which the environmental advantages to using natural dyes have been questioned. The initial chapter in this group provides both a historical look at natural dyes and a comprehensive compilation of natural dye structures and their sources. Though natural dyes are of interest as colorants for textiles, selected ones are used primarily in food and cosmetics.Chapter ten provides an update on the author's previous reviews of structure-color-relationships among precursors employed in the coloration of hair. Chemical constitutions characterizing hair dye structures are presented, along with a summary of available precursors and their environmental properties. Similarly, the chapter on leather dyes covers constitutions and nomenclature, in addition to providing interesting perspectives on the origin and use of leather, the dyeing of leather, and key environmental issues.This volume is concluded with another look at colors in nature. In this case, rather than revisiting colors in plant life, an interesting chapter dealing with color in the absence of colorants is presented. Chapter twelve covers basic concepts of color science and illustrates how 3-D assemblies leading to a plethora of colors are handled in nature. It is our hope that this atypical "color chemistry" chapter will invoke ideas that lead to the design of useful colorants.The chapters presented in this volume demonstrate that color chemistry still has much to offer individuals with inquiring minds who are searching for a career path. This work highlights the creativity of today's color chemists and the wide variety of interesting non-textile areas from which a career can be launched.
Author: Peter Bamfield
Publisher: Royal Society of Chemistry
ISBN: 1847550533
Category : Science
Languages : en
Pages : 395
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Book Description
Chromic phenomena, or those produced by materials which exhibit colour in response to a chemical or physical stimulus, have increasingly been at the heart of 'high-tec' developments in a variety of fields in the last decade. Many of the newer technologies, which are at the cutting edge of research, are multi-disciplinary, involving researchers from areas as diverse as physics, biology, materials science and electronic engineering. Chromic Phenomena covers five main areas: Colour change materials, such as photochromic, thermochromic and electrochromic materials; Materials which absorb and reflect light - the classical dyes and pigments; Luminescent phenomena, including phosphorescence, fluorescence and electroluminescence; Materials which absorb light and transfer energy, eg photosensitisers, infra-red absorbers and laser-addressable compounds; Phenomena involving the manipulation of light by chemicals, such as liquid crystals, lustre pigments, optoelectronics and photonics Providing an entry point both for new researchers and for established ones, this book, with its emphasis on the technological applications of these chromic phenomena, develops and investigates new applications for colour chemistry. It will be of interest to industrialists and professionals in the biological, medicinal, electronics/telecommunications and colorant industries, as well as academics in these fields.
Author: Elli Kohen
Publisher: Academic Press
ISBN: 1483269736
Category : Science
Languages : en
Pages : 490
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Book Description
Cell Structure and Function by Microspectrofluorometry provides an overview of the state of knowledge in the study of cellular structure and function using microspectrofluorometry. The book is organized into six parts. Part I begins by tracing the origins of modern fluorescence microscopy and fluorescent probes. Part II discusses methods such as microspectroscopy and flow cytometry; the fluorescence spectroscopy of solutions; and the quantitative implementation of fluorescence resonance energy transfer (FRET) in the light microscope. Part III presents studies on metabolism, including the mechanism of action of xenobiotics; biochemical analysis of unpigmented single cells; and cell-to-cell communication in the endocrine and the exocrine pancreas. Part IV focuses on applications of fluorescent probes. Part V deals with cytometry and cell sorting. It includes studies on principles and characteristics of flow cytometry as a method for studying receptor-mediated endocytosis; and flow cytometric measurements of physiologic cell responses. Part VI on bioluminescence discusses approaches to measuring chemiluminescence or bioluminescence in a single cell and measuring light emitted by living cells.
