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Author: James J. Kocsis
Publisher: Springer Science & Business Media
ISBN: 1468451340
Category : Science
Languages : en
Pages : 1028
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Book Description
This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
Author: James J. Kocsis
Publisher: Springer Science & Business Media
ISBN: 1468451340
Category : Science
Languages : en
Pages : 1028
Get Book Here
Book Description
This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
Author: Patrick M. Dansette
Publisher: Springer Science & Business Media
ISBN: 1461506670
Category : Science
Languages : en
Pages : 716
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Book Description
This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Université René Descartes, July 16-20, 2000.
Author: David Jollow
Publisher: Springer
ISBN: 9781461341260
Category : Science
Languages : en
Pages : 514
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Book Description
The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate to collect in one volume a series of reports outlining advances in the study of the formation of chemically active intermediary metabolic products of chemicals, mechanisms of toxicity or carcinogenesis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a wide variety of animal species while training large numbers of our colleagues who have been responsible for further advances in biochemistry, pharmacology, and toxicology. Another pioneer in the study of drug metabo lism, B. B.
Author: John Timbrell
Publisher: CRC Press
ISBN: 9780748407378
Category : Medical
Languages : en
Pages : 408
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Book Description
Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards. Following on from the acclaimed first two editions of Principles of Biochemical Toxicology, John Timbrell has expanded the text to include: summary sections questions and model answers thoroughly revised artwork These features, plus the new easy-to-read format will make biochemical toxicology more accessible to undergraduates and postgraduates coming across the subject for the first time, particularly when undertaking self-directed study. This comprehensive textbook provides a thorough explanation of dose-response relationships; disposition and metabolism; toxic responses to foreign compounds, and detailed examples to illustrate mechanisms of toxicity. There is also an expanded and updated bibliography, directing the reader to further reading if required. Students and lecturers will find the clear and concise approach, which established this book as the leading textbook in its field, an essential aid to learning and teaching.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1442
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Book Description
First multi-year cumulation covers six years: 1965-70.
Author: Robert Snyder
Publisher: Springer
ISBN: 9780306408021
Category : Science
Languages : en
Pages : 648
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Book Description
Gillette (USA), C.D. Klaassen (USA), J.J. Kocsis, (USA), D.B. Menzel (USA), M. Mercier (Belgium), R.A. Neal (USA), F. Oesch (BRD), S. Orrenius (Sweden), H. Remmer (BRD), M. Roberfroid (Belgium), H. Vainio (Finland) and C.M. Witmer (USA), acting 'as a committee under G.G. Gibson (UK), D.J. Jollow (USA), D.V. Parke (UK) and R. Snyder (USA), co-chairmen, THE SECOND INTERNATIONAL SYMPOSIUM ON BIOLOGICAL REACTIVE INTERMEDIATES was convened at the University of Surrey in the United Kingdom on July 14-17, 1980. This volume derives directly from the presentations at the symposium. The University of Surrey, which is located in Guildford, Surrey, provided a congenial atmosphere for this conference and we would like to take this opportunity to thank the local organizing committee and especially Dr. G. Gordon Gibson, for all their efforts in both scientific and social arrangements. Special thanks are extended also to the graduate students of the Biochemistry Department (especially Ms. Tricia Breacker and Mr. Paul Tamburini) and to the conference secretaries who unstintingly gave of their time in a variety of roles to ensure the smooth functioning of the symposium. We wish to acknowledge the tireless efforts of the distinguished scientists who agreed to chair the sessions of the symposium: A. Hildebrandt (BRD), H. Remmer (BRD), L. Goldberg (USA), S. Orrenius (Sweden), H. Uehleke (BRD), J.R. Gillette (USA), C. Netter (BRD), M. Mercier (Belgium), F. Oesch (BRD), E. Boyland (UK), J.E. Gibson (USA), C.D. Klaassen (USA) and J.W. Gorrod (UK). The mounting of a large scale international symposium is fraught with many impediments, not the least of which are the financial and logistical problems of assembling a group of internationally distinguished scientists in one place at the same time. Success in such endeavors requires concerned and active sponsors. The three sponsoring
Author:
Publisher: Elsevier
ISBN: 0081026919
Category : Science
Languages : en
Pages : 4266
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Book Description
Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience
Author: Matthew S. Platz
Publisher: John Wiley & Sons
ISBN: 0470120819
Category : Science
Languages : en
Pages : 492
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Book Description
The chemistry of reactive intermediates is central to a modern mechanistic and quantitative understanding of organic chemistry. Moreover, it underlies a significant portion of modern synthetic chemistry and is integral to a molecular view of biological chemistry. Reviews in Reactive Intermediate Chemistry presents an up-to-date, authoritative guide to this fundamental topic. Although it follows Reactive Intermediate Chemistry by the same authors, it serves as a free-standing resource for the entire chemical and biochemical community. The book includes: Relevant, practical applications Coverage of such topics as mass spectrometry methods, reactive intermediates in interstellar medium, quantum mechanical tunnelling, solvent effects, reactive intermediates in biochemical processes, and excited state surfaces Discussions of emerging areas, particularly those involving dynamics and theories Concluding sections identifying key directions for future research are provided at the end of each chapter
Author: Johannes Everse
Publisher: CRC Press
ISBN: 9780849369643
Category : Medical
Languages : en
Pages : 280
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Book Description
The second of two relatively independent volumes on the chemistry and biology of peroxidases. Volumes 2 covers the peroxidases isolated from plants and microorganisms, and includes detailed discussions of some of the unique reactions catalyzed by these enzymes. Volume one covered the peroxidases isolated from animal sources, as well as the "pseudo- peroxidase activity" of prostaglandin H synthase and of myoglobin and hemoglobin. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR
Author: Joan M. Braganza
Publisher: Manchester University Press
ISBN: 9780719034800
Category : Health & Fitness
Languages : en
Pages : 256
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Book Description
The second half of this century has been marked by the evolution of specialities in some branches of medicine, of which gastro-enterology has proved one of the more vigorous and successful. The development of intricate diagnostic and therapeutic techniques has fostered a tendency to overspecialization. In the past decade there has been a move to broaden the outlook. Workers who study the exocrine pancreas, both scientific and clinical, are now concerned not only with the endocrine pancreas but the liver and biliary tract as well because of the close embryological, anatomical and physiological relationships of the pancreas with these organs.
