Author: Tony J. Beugelsdijk
Publisher: Wiley-Interscience
ISBN:
Category : Medical
Languages : en
Pages : 336
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Book Description
An accessible overview of the latest advancements in automation technologies for genetic mapping—a blueprint for the laboratory of the future Although much has been written about the genetic science at work in the Human Genome Project, to date there has been a serious gap in the literature about the technology that propels the project. Bringing together a group of leading researchers, this work presents a unified vision of the vital role played by technological innovation in tackling the tremendous challenges of genome characterization. Areas covered include informatics, robotics, optical and microfabrication techniques, and information management systems. Accessible to geneticists and nongeneticists alike, this clearly written resource provides: Illuminating, firsthand case studies of laboratory automation and control systems at highly successful facilities, including workable models for standardized hardware and software interfaces Examinations of promising emergent technologies in such areas as capillary gel electrophoresis, miniaturization, and mass spectrometry Practical discussions of computer simulation and information management for use in the creation of efficient genome factories Tutorials throughout to clarify biological issues underlying each technology As one of the first books to address the spectrum of technologies that will carry genetic research into the next millennium, Automation Technologies for Genome Characterization is an indispensable reference for genome researchers as well as biologists, engineers, and computer scientists working in this exciting field. Wiley-Interscience Series on Laboratory Automation
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309112982
Category : Science
Languages : en
Pages : 300
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Book Description
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Author: G. P. Rdei
Publisher: World Scientific
ISBN: 9789810227807
Category : Science
Languages : en
Pages : 1150
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Book Description
"Redei has created an outstanding compendium of genetics. Arranged as a dictionary, the book is almost an encyclopedic collection of terms & concepts ... The author has managed to define terms with appropriate mixtures of depth & detail for the researcher, along with clarity useful for the nonexpert." Choice, 1998
Author: Roger L. Miesfeld
Publisher: John Wiley & Sons
ISBN: 0471156760
Category : Science
Languages : en
Pages : 308
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Book Description
This text explains the key biochemical and cell biological principles behind some of today's most commonly used applications of molecular genetics, using clear terms and well-illustrated flow schemes. The book is divided into several sections and moves from basic to advanced topics while providing a concise overview of fundamental concepts in modern biotechnology. Each chapter concludes with a Laboratory Practicum describing a hypothetical research objective and the sequence of steps that are most often used to investigate biological questions using molecular genetic methods. In addition, the book provides informative summaries of the latest advances in molecular genetics, using attractive illustrations and a comprehensive reference list. This text also introduces the use of Internet resources through the World Wide Web as a powerful new tool in molecular genetic research. Seven appendices are included in the book, providing a convenient information resource for properties of nucleic acids, protein and restriction enzymes, a description of common E. coli genetic markers and gel electrophoresis parameters, as well as a list of useful Internet address sites.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309224187
Category : Science
Languages : en
Pages : 354
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Book Description
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1398
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Book Description
Author: Eugene V. Koonin
Publisher: Springer Science & Business Media
ISBN: 1475737831
Category : Science
Languages : en
Pages : 482
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Book Description
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
Author: Carey-Ann D. Burnham
Publisher: Elsevier Health Sciences
ISBN: 0323188613
Category : Medical
Languages : en
Pages : 352
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Book Description
The field of Clinical Microbiology is evolving at a rapid pace, perhaps more so than any other arm of laboratory medicine. This can be attributed to new technology, including high throughput gene sequencing, multiplex molecular assays, rapid evolution of antimicrobial resistance, and discovery of new pathogens. In addition, modern medical procedures, such as solid organ and stem cell transplantation, have resulted in an explosion of infections with agents that historically have been considered to be of low virulence. This issue of Clinics in Laboratory Medicine will highlight some of the advances in diagnostic microbiology, including MALDI-TOF MS, pathogen discovery, and personalized antimicrobial chemotherapy. In addition, one of the papers will focus on implementation of new technologies and how to maximize patient impact of these new methods.
Author: Michael J. Heller
Publisher: CRC Press
ISBN: 0824742370
Category : Medical
Languages : en
Pages : 462
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Book Description
This book discusses the new generation of integrated microfabricated devices, including DNA chips, Lab-on-a-Chip, microcapillary electrophoresis systems, biosensors, and microanalytical systems. It traces their development with the established and evolving technologies such as microlithography, micromachining, microelectromechanical systems, microfluids, and nanotechnology.
Author: N. Patel
Publisher: Joseph Henry Press
ISBN: 0309172349
Category : Science
Languages : en
Pages : 313
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Book Description
Today's world poses a triple threat to the American population: infectious diseases, contamination of food and water, and bioattacks (biowarfare or bioterrorism). At least 17 countries are producing weapons of mass destruction using viruses, bacteria, or their toxins. AIDS, E. coli contamination, drug-resistant tuberculosis, and virulent flu strains are perhaps the best known of a host of disease threats. What these dangers have in common is the amount of data required to achieve solutions; in some cases, as much as a petabit (1 followed by 15 zeros) of data is required to study large numbers of samples from widespread locations. Firepower in the Lab examines how the nation can combat this triple threat by improving our ability to detect, measure, and monitor harmful biological agents. It explores the potential of today's exciting new laboratory automation and computer technologies as well as the emerging tools of molecular biology-how we can generate and analyze more data quickly and reduce human hands-on involvement, which inevitably introduces errors. The book discusses how to improve and apply technologies such as robotics, laboratory automation, "lab-on-a-chip," bioinformatics, and Internet control innovations. It reviews lessons learned from our experience with pandemic flu viruses. It also presents strategies for developing new high-throughput technologies, including how to address the lack of public funding for critical research undertakings.
