Asymmetric Synthesis of Three-Membered Rings PDF Download
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Author: Hélène Pellissier
Publisher: John Wiley & Sons
ISBN: 3527802037
Category : Science
Languages : en
Pages : 800
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Book Description
The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.
Author: Hélène Pellissier
Publisher: John Wiley & Sons
ISBN: 3527802037
Category : Science
Languages : en
Pages : 800
Get Book Here
Book Description
The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.
Author: Vitomir Šunjić
Publisher: Springer
ISBN: 3319299263
Category : Science
Languages : en
Pages : 221
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Book Description
This book connects a retrosynthetic or disconnection approach with synthetic methods in the preparation of target molecules from simple, achiral ones to complex, chiral structures in the optically pure form. Retrosynthetic considerations and asymmetric syntheses are presented as closely related topics, often in the same chapter, underlining the importance of retrosynthetic consideration of target molecules neglecting stereochemistry and equipping readers to overcome the difficulties they may encounter in the planning and experimental implementation of asymmetric syntheses. This approach prepares students in advanced organic chemistry courses, and in particular young scientists working at academic and industrial laboratories, for independently solving synthetic problems and creating proposals for the synthesis of complex structures.
Author: P. Andrew Evans
Publisher: Thieme
ISBN: 3131789611
Category : Science
Languages : en
Pages : 1172
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Book Description
The major emphasis here is on enantioselective reactions using asymmetric catalysts. Examples from the total synthesis of various natural and unnatural targets validates the utility of the synthetic methods. Specific topics discussed: cycloaddition, cycloisomerization and sigmatropic rearrangement reactions, allylic and carbonyl functionalization reactions, metal-catalyzed cross-coupling reactions, desymmetrization, fluorination, polymerization and sulfide oxidation reactions. This volume is part of a 3-volume set: Science of Synthesis Stereoselective Synthesis Workbench Edition Further information about Stereoselective Synthesis (including sample pages and the table of contents)
Author: Norbert Krause
Publisher: John Wiley & Sons
ISBN: 9783527297733
Category : Science
Languages : en
Pages : 396
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Book Description
Organocopper compounds are now an integral part of every modern synthesis laboratory, allowing important stages of synthesis to be carried out in an elegant fashion. Yet a certain amount of experience is needed if they are to be used effectively. Non-experts in the field often have difficulty in choosing the most suitable reagent for a particular substrate and the prerequisites for the reaction.This manual, edited by Norbert Krause, answers such questions, since it contains all the useful tips and tricks on organocopper compounds - information gained from personal experience by the international team of authors. This allows those working in laboratories in both academia and industry to determine the optimal reagent for their needs using the substrates available for reaction and the desired products. The result is a more effective use of these synthesis tools in everyday laboratory practice.
Author: Hélène Pellissier
Publisher: John Wiley & Sons
ISBN: 3527341145
Category : Science
Languages : en
Pages : 606
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Book Description
The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.
Author:
Publisher: Academic Press
ISBN: 0128174749
Category : Science
Languages : en
Pages : 440
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Book Description
Advances in Heterocyclic Chemistry, Volume 129 is the definitive series in the field—one of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive, updated release includes chapters on Metal-Catalyzed Direct Arylation of 1,2-Azoles, The Literature of Heterocyclic Chemistry, Part XVII, 2017, Pyrrolo-, Imidazoquinolines and Pyrroloquinazolines with a Bridgehead Nitrogen, Synthesis and Reactions of Arsole, Stibole, and Bismole, Advances in Synthesis and Chemistry of Aziridines, and more. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds
Author: Gautam Patel
Publisher: Elsevier
ISBN: 0443223254
Category : Technology & Engineering
Languages : en
Pages : 660
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Book Description
Modern advances in organic synthesis require compouds having attractive properties with high percentage of yield. Spirooxindole examines the current state of the art, recent progress and new challenges associated with the development of spirooxindole derivatives for various medicinal applications. Owing to their exceptional properties, these compounds can be used in vaious fields, including chemical and pharma industries, and in clinical research. This book has chapters written by experts in several different areas. It serves as a useful reference book for scientists, industrial practitioners, graduate students, and other professionals in the field of hetrocyclic chemistry, medicinal chemistry, organic synthesis clinical research and chemical sciences.The growing interest among the academics and industrial researchers in the field of organic chemistry and medicinal chemistry is the driving force for the presentation of this edited book. - Consolidates information on each aspect of this novel compound and its applications in various fields, covering the entire spectrum of up-to-date literature citations, current market, and patents - Provides a comprehensive, in-depth description of spirooxindole derivatives as well as multipurpose scaffolds - Highlights green synthesis and nanocatalysis - Describes in-depth various medicinal applications - Covers both synthesis and applications
Author: Hélène Pellissier
Publisher: Royal Society of Chemistry
ISBN: 1788015150
Category : Science
Languages : en
Pages : 375
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Book Description
With a foreword from leading organic chemist Professor Paul Wender, this book collects the major developments reported in the past thirty years in the field of enantioselective reactions promoted by chiral cobalt catalysts, illustrating the power of these green catalysts to provide all types of organic reactions from the basic to completely novel methodologies. The search for new methodologies to prepare optically pure products is one of the most active areas of research in organic synthesis. Of the methods available for preparing chiral compounds, catalytic asymmetric synthesis has attracted the most attention. In particular, asymmetric transition-metal catalysis is a powerful tool for performing reactions in a highly enantioselective fashion. Efforts to develop new asymmetric transformations have previously focused on the use of rare metals such as titanium, palladium, iridium and gold. However, the ever-growing need for environmentally friendly catalytic processes has prompted chemists to focus on the more abundant and less toxic first-row transition metals, such as cobalt, to develop new catalytic systems. The ability of cobalt catalysts to adopt unexpected reaction pathways has led to an impressive number of enantioselective cobalt-promoted transformations being developed over the past three decades. These have included the synthesis of many different types of products, often under relatively mild conditions and with remarkable enantioselectivities. This book is a useful reference resource for chemists, both academic and industrial, working in organic synthesis and interested in greener or more economical catalytic alternatives.
Author: Wei Zhang
Publisher: John Wiley & Sons
ISBN: 1119288177
Category : Science
Languages : en
Pages : 730
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Book Description
An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.
Author: Andrei K. Yudin
Publisher: John Wiley & Sons
ISBN: 9783527312139
Category : Science
Languages : en
Pages : 532
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Book Description
Aziridines and epoxides are among the most widely used intermediates in organic synthesis, acting as precursors to complex molecules due to the strains incorporated in their skeletons. Besides their importance as reactive intermediates, many biologically active compounds also contain these three-membered rings. Filling a gap in the literature, this clearly structured book presents the much needed information in a compact and concise way. The renowned editor has succeeded in gathering together excellent authors to cover synthesis, applications, and the biological aspects in equal depth. Divided roughly equally between aziridines and epoxides, the twelve chapters discuss: * Synthesis of aziridines * Nucleophilic ring-opening of aziridines and epoxides * Organic synthesis with aziridine building blocks * Vinyl aziridines in organic synthesis * Diastereoselective aziridination reagents * Synthetic aspects of aziridinomitocene chemistry * Biosynthesis of biologically important aziridines * Organic catalysis of epoxide and aziridine ring formation * Metal-mediated synthesis of epoxides * Asymmetric epoxide ring opening chemistry * Epoxides in complex molecule synthesis * Biological activity of epoxide-containing molecules A high-quality reference manual for academic and industrial chemists alike.
