Environmental Effects of Dredging Technical Notes. Assessment of the Genotoxic Potential of Dredged Material PDF Download
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Languages : en
Pages : 6
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Book Description
This technical note describes an approach for assessing the genotoxic potential of dredged material. The use of integrated batteries of rapid and mechanistically interpretable in vitro and in vivo assays in a tiered approach is fundamental to applied toxicology. The research described here brings this approach to the testing of sediments. Work completed to date and future work will mesh to form an advanced and cost-effective methodology. The purpose of this methodology is to increase the accuracy of environmental risk assessments and facilitate making decisions concerning open-water disposal of dredged material. A great number of the contaminants typically found in dredged material are toxic to exposed organisms through effects on DNA. Such effects are usually the result of low-level chronic exposures. These effects can result in reproductive failure of organisms, impaired growth and development of offspring, and tumors (often cancerous) in vertebrates. Collectively, such effects are called 'genotoxicity' and result from damage to the genome of a cell. The damage is heritable, that is, passed on to future cell generations upon duplication of the affected cells.
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Languages : en
Pages : 6
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Book Description
This technical note describes an approach for assessing the genotoxic potential of dredged material. The use of integrated batteries of rapid and mechanistically interpretable in vitro and in vivo assays in a tiered approach is fundamental to applied toxicology. The research described here brings this approach to the testing of sediments. Work completed to date and future work will mesh to form an advanced and cost-effective methodology. The purpose of this methodology is to increase the accuracy of environmental risk assessments and facilitate making decisions concerning open-water disposal of dredged material. A great number of the contaminants typically found in dredged material are toxic to exposed organisms through effects on DNA. Such effects are usually the result of low-level chronic exposures. These effects can result in reproductive failure of organisms, impaired growth and development of offspring, and tumors (often cancerous) in vertebrates. Collectively, such effects are called 'genotoxicity' and result from damage to the genome of a cell. The damage is heritable, that is, passed on to future cell generations upon duplication of the affected cells.
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Category :
Languages : en
Pages : 7
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Book Description
This technical note describes an approach for assessing the genotoxic potential of dredged material. The use of integrated batteries of rapid and mechanistically interpretable in vitro and in vivo assays in a tiered approach is fundamental to applied toxicology. The research described here brings this approach to the testing of sediments. Work completed to date and future work will mesh to form an advanced and cost effective methodology. The purpose of this methodology is to increase the accuracy of environmental risk assessments and facilitate making decisions concerning open-water disposal of dredged material.
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Languages : en
Pages : 11
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Book Description
This technical note reports and compares initial results of six genotoxicity bioassays applied to dredged sediments and describes progress toward development of a testing protocol to aid in regulatory decisionmaking when genotoxic chemicals are an issue of concern. The Long-term Effects of Dredging Operations Program work unit Genotoxicity of contaminated Dredged Material was initiated in fiscal year 1990 to develop methods for assessing the genotoxic potential of dredged sediments. The impetus driving this new research and development effort was specific regulatory language in section 103 of the Ocean Dumping Act (Marine Protection, Research, and Sanctuaries Act (MPRsA) of 1972) prohibiting the open-water discharge of mutagenic, carcinogenic, or teratogenic substances in other than trace amounts, and language less specific but of similar intent in section 404 of the Clean Water Act (CWA). pg1. JMD.
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Languages : en
Pages : 8
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This technical note is the second in a series of three that outline and describe the principal methods that have been developed to test the potential of environmental contaminants for causing mutagenic, carcinogenic, and teratogenic effects. The first in this series (EEDP-04-24) describes methods used to discern genotoxic effects at the subcellular level, while this technical note describes methods used to discern genotoxic effects at the cellular and organ/ organism level. Recent literature citations for each topic are listed in the third technical note (EEDP-04-26) to assist readers in locating source information. A glossary of terms is also provided in Technical Note EEDP-O4-26. The information in these technical notes is intended to provide Corps of Engineers personnel with a working knowledge of the terminology and conceptual basis of genotoxicity testing. To develop an improved understanding of the concepts of genotoxicity, readers are encouraged to review "A Primer in Genotoxicity" (Farvis, Reilly, and Lutz 1993), presented in Volume D-933 of the Environmental Effects of Dredgtng information exchange bulletin.
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Category :
Languages : en
Pages :
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Author:
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ISBN:
Category : Environmental quality
Languages : en
Pages : 588
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Author: Environmental Commission. Working Group 8
Publisher: PIANC
ISBN: 2872231552
Category : Contaminated sediments
Languages : en
Pages : 60
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Author: United States. Congress. House. Committee on Science. Subcommittee on Technology
Publisher:
ISBN:
Category : Law
Languages : en
Pages : 156
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Author: DIANE Publishing Company
Publisher: DIANE Publishing
ISBN: 0788149768
Category :
Languages : en
Pages : 153
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Book Description
Discusses the impact of environmental policy & regulation on the development & use of environmental technology, & ways to best employ & promote environmental technologies using the government to act in partnership. Presents testimony from David M. Gardiner, Asst. Administrator for Policy, Planning, & Evaluation, EPA; Walter W. Kovalick, Director, Technology Innovation Office, Office of Solid Waste & Emergency Response, EPA; John Uhr, Sales & Marketing Manager, CETAC Technologies, Inc.; Jan Geiselman Power, President, Power & Assoc. Corp; & Peter A. Carroll. V.P. for Government Affairs, Solar Turbines, Inc.
Author: Cornelis Anton Schipper
Publisher: IOS Press
ISBN: 160750085X
Category : Science
Languages : en
Pages : 164
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Book Description
Water, sediment, and flounder tissue were analyzed from rivers, harbors, canals, and sites along coast of the Netherlands.
