Approaches to Drug Sample Differentiation PDF Download
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Author: Juei H. Liu
Publisher:
ISBN:
Category : Chemistry, Forensic
Languages : en
Pages : 92
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Book Description
Author: Juei H. Liu
Publisher:
ISBN:
Category : Chemistry, Forensic
Languages : en
Pages : 92
Get Book Here
Book Description
Author: JH. Liu
Publisher:
ISBN:
Category : Analytical chemistry
Languages : en
Pages : 5
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Book Description
Differentiation of drug samples can be based on at least three different approaches. Conventional methods use qualitative and quantitative determinations of impurities or minor components. Samples may also be differentiated by variations in a naturally occurring isotope such as carbon-13, whose content varies because of differences of carbon fixation conditions for cultivated plant drugs or from differences in reaction conditions for synthesized drugs. A third approach involves the determination of various diastereoisomeric or enantiomeric compositions or both. This last approach also serves an essential purpose in cases where one isomer is under regulation while other(s) may not be. Representative works are reviewed.
Author: JH. Liu
Publisher:
ISBN:
Category : Amphetamine
Languages : en
Pages : 10
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Book Description
A gas chromatograph/mass spectrometer (GC/MS) system equipped with a chiral and an achiral capillary column is used to analyze control methamphetamine, an illicit methamphetamine preparation ("White Cross"), and a simulated illicit methamphetamine synthesis product. Samples are derivatized with N-trifluoroacetyl-l-prolyl chloride (I-TPC) before the GC/MS analysis. The results obtained lead to the conclusion that the resolution on an achiral column is adequate for the determination of methamphetamine enantiomers and impurities, providing the enantiomeric impurity of the l-TPC is known. Four new possible by-products of methamphetamine preparations were identified in the simulated illicit methamphetamine synthesis product.
Author: JH. Liu
Publisher:
ISBN:
Category : Amphetamine
Languages : en
Pages : 8
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Book Description
Synthesized tris[d,d-dicampholylmethanato]europium(III), Eu(dcm)3, and three other commercially available chiral lanthanide shift reagents are used to resolve the nuclear magnetic resonance (NMR) spectra of the enantiomeric N-CH3 and C-CH3 protons in d- and l-methamphetamine. The chemical shift difference between the corresponding enantiomeric protons induced by these four shift reagents are compared and evaluated in their prospective use for enantiomeric identification and determination. It is concluded that while the chemical shift difference between the two enantiomerie C-CH3 protons induced by Eu(dcm)3 is most suitable for qualitative identification of these enantiomers, the NMR spectra of the N-CH3 protons are best resolved by Eu(dcm)3 and most suitable for quantitative determinations.
Author: Ashraf Mozayani
Publisher: Springer Science & Business Media
ISBN: 159259946X
Category : Medical
Languages : en
Pages : 307
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Book Description
A comprehensive and easy-to-read introduction to the work of the modern forensic laboratory. The authors explain in simple language the capabilities and limitations of modern forensic laboratory procedures, techniques, analyses, and interpretations. Here, the interested reader will find an understandable and fascinating introduction to the complex worlds of forensic serology DNA, chemistry, crime reconstruction, digital evidence, explosives, arson, fingerprints, firearms, tool marks, odontology, and pathology. Additional chapters address the problems of assuring quality and seeking trace evidence in the forensic laboratory.
Author: Richard Saferstein
Publisher: Prentice Hall
ISBN:
Category : Law
Languages : en
Pages : 488
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Book Description
Collection of articles written by experts in the forensic science area. Volume III has an emphasis on DNA research. Book is intended for the professional/graduate audience.
Author:
Publisher: Elsevier
ISBN: 0128032014
Category : Technology & Engineering
Languages : en
Pages : 4609
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Book Description
Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Author: Danilo Arnone
Publisher: Frontiers Media SA
ISBN: 2889747670
Category : Medical
Languages : en
Pages : 120
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Book Description
Author: Anssi Roiha
Publisher: John Catt
ISBN: 1398382906
Category : Education
Languages : en
Pages : 281
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Book Description
Differentiation is an approach to education in which every student's individuality and special needs are taken into account. Practical and accessible, HOW TO SUCCEED IN DIFFERENTIATION reveals the approach taken in the high-achieving Finnish education system, where the national curriculum obligates all teachers to differentiate their teaching from the get-go. The book is divided into four parts. Part I explains the background of Finnish education and differentiation in the Finnish context. Part II investigates the theoretical basis for differentiation and strives to offer new perspectives for the most common challenges of differentiation. In addition, Part II introduces the reader to the imaginary example students, whose problems are attempted to be solved later in the book. In Part III, differentiation is approached through the five-dimensional model of differentiation, which the authors have created and which, in their opinion, covers the most central areas of teaching, in which differentiation should be acknowledged. In Part IV, differentiation is exemplified in language and literature, mathematics and foreign languages.
Author: Jocelyn M. Hicks
Publisher:
ISBN: 9780915274628
Category : Medical
Languages : en
Pages : 340
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Book Description
DORA '92-93 provides essential ordering information for rare tests that are clinically significant yet available through only a few clinical laboratories in the country. It includes a directory that is a proven time-saver & now completely updated, expanded, & reformatted to help you quickly find what you need. Compiled from a comprehensive nationwide survey of clinical laboratories, DORA '92-93 tells you where to get the lab work done & how to prepare the specimens for unusual toxic compounds; metabolic diseases; specific diseases using gene probes; infrequently measured drugs; enzymes; steroids; environmental pollutants & other infrequently requested analyses. Each entry contains: Name & address of laboratory; Contact person & phone number; Specifics on special preparation of the patient; Shipping instructions; Cost analyses; References for procedure; Reference values; How long it will take to get results; Any special restrictions; What's new in this Edition: 1,479 lab tests, 448 more than last edition. Lists 598 tests not included in previous edition. Lists 228 labs in the Laboratory Index. "Includes all tests a Department of Laboratory Medicine might wish performed...the information would be difficult to assemble on a personal basis. This has to be one of the more useful books for a laboratory manager." - AMT Events.
