Approaches to Drug Sample Differentiation PDF Download
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Author: Juei H. Liu
Publisher:
ISBN:
Category : Chemistry, Forensic
Languages : en
Pages : 92
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Book Description
Author: Juei H. Liu
Publisher:
ISBN:
Category : Chemistry, Forensic
Languages : en
Pages : 92
Get Book Here
Book Description
Author: JH. Liu
Publisher:
ISBN:
Category : Analytical chemistry
Languages : en
Pages : 5
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Book Description
Differentiation of drug samples can be based on at least three different approaches. Conventional methods use qualitative and quantitative determinations of impurities or minor components. Samples may also be differentiated by variations in a naturally occurring isotope such as carbon-13, whose content varies because of differences of carbon fixation conditions for cultivated plant drugs or from differences in reaction conditions for synthesized drugs. A third approach involves the determination of various diastereoisomeric or enantiomeric compositions or both. This last approach also serves an essential purpose in cases where one isomer is under regulation while other(s) may not be. Representative works are reviewed.
Author: JH. Liu
Publisher:
ISBN:
Category : Amphetamine
Languages : en
Pages : 8
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Book Description
Synthesized tris[d,d-dicampholylmethanato]europium(III), Eu(dcm)3, and three other commercially available chiral lanthanide shift reagents are used to resolve the nuclear magnetic resonance (NMR) spectra of the enantiomeric N-CH3 and C-CH3 protons in d- and l-methamphetamine. The chemical shift difference between the corresponding enantiomeric protons induced by these four shift reagents are compared and evaluated in their prospective use for enantiomeric identification and determination. It is concluded that while the chemical shift difference between the two enantiomerie C-CH3 protons induced by Eu(dcm)3 is most suitable for qualitative identification of these enantiomers, the NMR spectra of the N-CH3 protons are best resolved by Eu(dcm)3 and most suitable for quantitative determinations.
Author: JH. Liu
Publisher:
ISBN:
Category : Amphetamine
Languages : en
Pages : 10
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Book Description
A gas chromatograph/mass spectrometer (GC/MS) system equipped with a chiral and an achiral capillary column is used to analyze control methamphetamine, an illicit methamphetamine preparation ("White Cross"), and a simulated illicit methamphetamine synthesis product. Samples are derivatized with N-trifluoroacetyl-l-prolyl chloride (I-TPC) before the GC/MS analysis. The results obtained lead to the conclusion that the resolution on an achiral column is adequate for the determination of methamphetamine enantiomers and impurities, providing the enantiomeric impurity of the l-TPC is known. Four new possible by-products of methamphetamine preparations were identified in the simulated illicit methamphetamine synthesis product.
Author: J. Andrew Williams
Publisher: John Wiley & Sons
ISBN: 0470170832
Category : Medical
Languages : en
Pages : 420
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Book Description
Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Author: C L Thomas
Publisher: Elsevier
ISBN: 1483292827
Category : Education
Languages : en
Pages : 297
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Book Description
The Sampling Source Book is an invaluable guide to the world's literature on sampling and provides a timely and much needed focus on what is a diverse and important subject. Based on an exhaustive search of the world's literature, this index containsbibliographic references to journal articles, patents, conference proceedings, books, technical reports and standards. Details of databases searched and outlines are provided as to how the searches were conducted to facilitate update of the data by usersof the index. The material contained in this source book has been assessed by specialists in sampling operations; assuring relevance of the material included. Comprehensive lists of suppliers of sampling equipment, consultants and professional bodieswith expertise and interests in sampling are also presented.
Author: Ashraf Mozayani
Publisher: Springer Science & Business Media
ISBN: 159259946X
Category : Medical
Languages : en
Pages : 307
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Book Description
A comprehensive and easy-to-read introduction to the work of the modern forensic laboratory. The authors explain in simple language the capabilities and limitations of modern forensic laboratory procedures, techniques, analyses, and interpretations. Here, the interested reader will find an understandable and fascinating introduction to the complex worlds of forensic serology DNA, chemistry, crime reconstruction, digital evidence, explosives, arson, fingerprints, firearms, tool marks, odontology, and pathology. Additional chapters address the problems of assuring quality and seeking trace evidence in the forensic laboratory.
Author: JaVed I. Khan
Publisher: Springer Science & Business Media
ISBN: 1934115061
Category : Medical
Languages : en
Pages : 360
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Book Description
This book focuses on a marvel approach that blends chemistry with forensic science and is used for the examination of controlled substances and clandestine operations. The book will particularly interest forensic chemists, forensic scientists, criminologists, and biochemists.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309269393
Category : Medical
Languages : en
Pages : 377
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Book Description
The adulteration and fraudulent manufacture of medicines is an old problem, vastly aggravated by modern manufacturing and trade. In the last decade, impotent antimicrobial drugs have compromised the treatment of many deadly diseases in poor countries. More recently, negligent production at a Massachusetts compounding pharmacy sickened hundreds of Americans. While the national drugs regulatory authority (hereafter, the regulatory authority) is responsible for the safety of a country's drug supply, no single country can entirely guarantee this today. The once common use of the term counterfeit to describe any drug that is not what it claims to be is at the heart of the argument. In a narrow, legal sense a counterfeit drug is one that infringes on a registered trademark. The lay meaning is much broader, including any drug made with intentional deceit. Some generic drug companies and civil society groups object to calling bad medicines counterfeit, seeing it as the deliberate conflation of public health and intellectual property concerns. Countering the Problem of Falsified and Substandard Drugs accepts the narrow meaning of counterfeit, and, because the nuances of trademark infringement must be dealt with by courts, case by case, the report does not discuss the problem of counterfeit medicines.
Author: Ashraf Mozayani
Publisher: Springer Science & Business Media
ISBN: 1607618729
Category : Medical
Languages : en
Pages : 604
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Book Description
Forensic science has come a long way in the past ten years. It is much more in-depth and much broader in scope, and the information gleaned from any evidence yields so much more information than it had in the past because of incredible advances in analytic instruments and crucial procedures at both the crime scene and in the lab. Many practices have gone digital, a concept not even fathomed ten years ago. And from the first collection of evidence to its lab analysis and interpretation to its final presentation in court, ethics has become an overriding guiding principle. That’s why this new edition of this classic handbook is indispensable. The Forensic Laboratory Handbook Procedures and Practice includes thirteen new chapters written by real-life practitioners who are experts in the field. It covers the tried and true topics of fingerprints, trace evidence, chemistry, biology, explosives and arson, forensic anthropology, forensic pathology, forensic documents, firearms and toolmarks. This text also addresses an array of new topics including accreditation, certification, ethics, and how insects and bugs can assist in determining many facts including a margin of time of death. In the attempt to offer a complete and comprehensive analysis The Forensic Laboratory Handbook Procedures and Practice also includes a chapter discussing the design of a laboratory. In addition, each chapter contains educational requirements needed for the discipline it covers. Complete with questions at the end of each chapter, brief author bios and real crime scene photos, this text has risen to greet the many new challenges and issues that face today’s forensic crime practitioners.
