Apparatus and Method of Determining Molecular Weight of Large Molecules PDF Download
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Languages : en
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A mass spectrometer determines the mass of multiply charged high molecular weight molecules. This spectrometer utilizes an ion detector which is capable of simultaneously measuring the charge z and transit time of a single ion as it passes through the detector. From this transit time, the velocity of the single ion may then be derived, thus providing the mass-to-charge ratio m/z for a single ion which has been accelerated through a known potential. Given z and m/z, the mass m of the single ion can then be calculated. Electrospray ions with masses in excess of 1 MDa and charge numbers greater than 425 e.sup.- are readily detected. The on-axis single ion detection configuration enables a duty cycle of nearly 100% and extends the practical application of electrospray mass spectrometry to the analysis of very large molecules with relatively inexpensive instrumentation.
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Languages : en
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Book Description
A mass spectrometer determines the mass of multiply charged high molecular weight molecules. This spectrometer utilizes an ion detector which is capable of simultaneously measuring the charge z and transit time of a single ion as it passes through the detector. From this transit time, the velocity of the single ion may then be derived, thus providing the mass-to-charge ratio m/z for a single ion which has been accelerated through a known potential. Given z and m/z, the mass m of the single ion can then be calculated. Electrospray ions with masses in excess of 1 MDa and charge numbers greater than 425 e.sup.- are readily detected. The on-axis single ion detection configuration enables a duty cycle of nearly 100% and extends the practical application of electrospray mass spectrometry to the analysis of very large molecules with relatively inexpensive instrumentation.
Author: Heinrich Biltz
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Languages : en
Pages : 262
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Author: Robert U. Bonnar
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Category : Molecular weights
Languages : en
Pages : 328
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Author: Kenji Iwamoto
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Category :
Languages : en
Pages : 4
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Category : Patents
Languages : en
Pages : 1140
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Author: Philip E. Slade
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Category : Science
Languages : en
Pages : 360
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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309168392
Category : Science
Languages : en
Pages : 238
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Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.
Author: Richard Bell Moyes
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Category : Science
Languages : en
Pages : 102
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Author: United States. Patent and Trademark Office
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Category : Patents
Languages : en
Pages : 1384
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Author: The Open The Open Courses Library
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ISBN: 9781670682796
Category :
Languages : en
Pages : 47
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Molecular Weight Determination Physical Methods in Chemistry and Nano Science The cryoscopic method was formally introduced in the 1880's when François-Marie Raoult published how solutes depressed the freezing points of various solvents such as benzene, water, and formic acid. He concluded from his experimentation "if one molecule of a substance can be dissolved in one-hundred molecules of any given solvent then the solvent temperature is lowered by a specific temperature increment". Based on Raoult's research, Ernst Otto Beckmann invented the Beckmann thermometer and the associated freezing - point apparatus, which was a significant improvement in measuring freezing - point depression values for a pure solvent. The simplicity, ease, and accuracy of this apparatus has allowed it to remain as a current standard with few modifications for molecular weight determination of unknown compounds. Chapter Outline: Solution Molecular Weight of Small Molecules Molecular Weight of Polymers Size Exclusion Chromatography and its Application in Polymer Science The Open Courses Library introduces you to the best Open Source Courses.
