Angiogenesis in Brain Tumors PDF Download
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Author: Matthias Kirsch
Publisher: Springer Science & Business Media
ISBN: 1441988718
Category : Medical
Languages : en
Pages : 376
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Book Description
- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field
Author: Matthias Kirsch
Publisher: Springer Science & Business Media
ISBN: 1441988718
Category : Medical
Languages : en
Pages : 376
Get Book Here
Book Description
- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field
Author: Matthias Kirsch
Publisher: Springer Science & Business Media
ISBN: 9781402077043
Category : Medical
Languages : en
Pages : 376
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Book Description
- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field
Author: I.D. Goldberg
Publisher: Springer Science & Business Media
ISBN: 9783764353094
Category : Medical
Languages : en
Pages : 524
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Book Description
thrombospondin-l may be encoded by a tumor suppressor gene. Dr. O'Reilly discusses angiostatin, an exciting recently discovered factor derived from the fibrinolytic proenzyme plasminogen that inhibits tumor angiogenesis, primary tumor growth, and formation of metastases. In addition to the soluble class of angiogenesis-regulatory factors discussed above, interactions of endothelial cells with components of the extracellular matrix and with other cell types are critical for proper formation of vessels. Drs. Grant and Kleinman discuss the role of laminin and other matrix molecules in regulation of capillary formation. Dr. van Hinsbergh and colleagues describe the role of fibrin and the fibrinolytic system in angiogenesis associated with wound repair. Cell surface mole cules that interact with the extracellular matrix have been implicated in the regulation of angiogenesis. Dr. Varner discusses some exciting new studies on the roles of specific vascular cell integrins (a /33 and a /3s) in mediating v v tumor angiogenesis and angiogenesis associated with wound healing. The pericyte, a vascular smooth muscle-like cell, exerts a powerful regulatory effect during the later stages of angiogenesis in which mature capillaries are formed. These mechanisms are discussed by Drs. Hirschi and D' Amore. With all the recent progress in the molecular biology of angiogenesis, the contribution of microenvironmental conditions such as hypoxia and pH to angiogenesis is often ignored. Drs. Rockwell and Knisely review this area of investigation and present studies of experimental tumor models.
Author: Domenico Ribatti
Publisher: Academic Press
ISBN: 0128194944
Category : Science
Languages : en
Pages : 198
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Book Description
Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
Author: Jawahar Mehta
Publisher: Springer Science & Business Media
ISBN: 1461458579
Category : Medical
Languages : en
Pages : 536
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Book Description
Angiogenesis is a highly complex phenomenon where new blood vessels are formed for the supply of oxygen and nutrients in different organs of the body. It plays a critical role in both physiological processes such as growth and development as well as pathological processes including cancer and different types of tumors. Angiogenesis is also essential for the regeneration and survival of cells in several disease conditions such as ischemic heart disease (myocardial infarction), atherosclerosis, brain injury (stroke) and diabetes. Since the mechanisms of angiogenesis are organ specific and differ among various diseases, it is proposed to devote one section of this book to the development of angiogenesis in some selected diseases such as cancer, ischemic heart disease, atherosclerosis, diabetes and stroke. It is pointed out that extensive research work in this regard has been carried out in the area of cancer and heart disease, whereas relatively less attention has been paid to studying angiogenesis in other disease conditions.
Author: Terry Lichtor
Publisher: BoD – Books on Demand
ISBN: 9535109898
Category : Medical
Languages : en
Pages : 652
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Book Description
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
Author: Ronald H. Goldfarb
Publisher: Springer Science & Business Media
ISBN: 1461526221
Category : Medical
Languages : en
Pages : 186
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Book Description
It is widely appreciated that the pathophysiology of advanced brain cancer is intimately related to the extent of tumor invasiveness. A prerequisite for comprehensively understanding neuro-oncology is therefore the elucidation of the biochemical and molecular properties of tumor cells that contribute to their invasiveness. An understanding of tumor invasion for central nervous system tumors is crucial since malignant brain tumors are very highly invasive and extensively destroy adjacent neural brain tissue. Moreover, they are angiogenesis-dependent and lead to the death of patients by expanding within the limited space of the cranium. As more specific insights are gained towards a full understanding of the complex process of tumor invasiveness of brain tumor cells, it should be possible to design strategies for the early diagnosis and treatment of invasive, advanced brain tumors. There is therefore an urgent need to better understand the cellular properties of brain tumor cells responsible for invasiveness. This special issue of the JOURNAL OF NEURO-ONCOLOGY provides a state-of-the-art review of the general understanding of the process of tumor invasion. In addition, the articles emphasize specific aspects of aggressive brain cancers which are particularly important for deriving new insights for therapeutic approaches for advanced brain cancer that will target tumor invasiveness. The ideas discussed will stimulate further studies directed towards the translation of these important invasion-related studies to clinical approaches for the effective treatment of brain cancer.
Author: Pieter Wesseling
Publisher:
ISBN: 9789090104874
Category :
Languages : en
Pages : 160
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Book Description
Zsfassung in niederländ. Sprache.
Author: Prashant Kesharwani
Publisher: Academic Press
ISBN: 0128122498
Category : Medical
Languages : en
Pages : 478
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Book Description
Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors
Author: Domenico Ribatti
Publisher: Springer Science & Business Media
ISBN: 1402095635
Category : Medical
Languages : en
Pages : 126
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Book Description
In 1971, J. Folkman published in the “New England Journal of Medicine” a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis. Beginning in the 1980’s, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy. This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.
