Analysis of the Bacillus Subtilis ECF Sigma Factor, [sigma Superscript M] and Its' Regulon PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Analysis of the Bacillus Subtilis ECF Sigma Factor, [sigma Superscript M] and Its' Regulon PDF full book. Access full book title Analysis of the Bacillus Subtilis ECF Sigma Factor, [sigma Superscript M] and Its' Regulon by Christopher Wallace Houston. Download full books in PDF and EPUB format.
![Analysis of the Bacillus Subtilis ECF Sigma Factor, [sigma Superscript M] and Its' Regulon PDF](https://books.google.com/books/content/images/frontcover/M-H3PgAACAAJ?fife=w150-h200)
Author: Christopher Wallace Houston
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
![Analysis of the Bacillus Subtilis ECF Sigma Factor, [sigma Superscript M] and Its' Regulon PDF](https://books.google.com/books/content/images/frontcover/M-H3PgAACAAJ?fife=w80-h100)
Author: Christopher Wallace Houston
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Boyan B. Bonev
Publisher: John Wiley & Sons
ISBN: 111994077X
Category : Science
Languages : en
Pages : 288
Get Book Here
Book Description
AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era—when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death—new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics – From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics – From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.
Author: Wolfgang Schumann (Prof. Dr. rer. nat.)
Publisher: John Wiley & Sons
ISBN:
Category : Mathematics
Languages : en
Pages : 404
Get Book Here
Book Description
Functional Analysis of Bacterial Genes: A Practical Manual summarises the principles and the key methods used to analyse the function of genes in bacteria. Written by members of the Bacillus subtilis Functional Analysis Consortium, this book provides a guide to the many approaches for the systematic analysis of gene function. Features include: * In-depth discussion of the theory and application of the methods * A step-by-step practical guide to each method * Experimental examples to indicate expected results * Contact information for suppliers and resource centres Written by internationally recognised authors, Functional Analysis of Bacterial Genes: A Practical Manual will be a valuable resource to researchers and technicians using functional analysis for many bacterial species, whether in the academic departments of microbiology or genetics, the biotechnology, biomedicine or pharmaceutical industries, or other centres of genomics and bioinformatics. "This volume, and the pioneering effort it represents, will be of interest not only to those of us who are specialists in B. subtilis but to all microbiologists and genome scientists who face the formidable task of uncovering the functions of the myriad uncharacterised genes that are emerging from large-scale sequencing." - Richard Losick , The Biological Laboratories, Harvard University, Cambridge, Massachusetts, USA
Author: David R. Boone
Publisher: Springer Science & Business Media
ISBN: 038721609X
Category : Science
Languages : en
Pages : 717
Get Book Here
Book Description
Bacteriologists from all levels of expertise and within all specialties rely on this Manual as one of the most comprehensive and authoritative works. Since publication of the first edition of the Systematics, the field has undergone revolutionary changes, leading to a phylogenetic classification of prokaryotes based on sequencing of the small ribosomal subunit. The list of validly named species has more than doubled since publication of the first edition, and descriptions of over 2000 new and realigned species are included in this new edition along with more in-depth ecological information about individual taxa and extensive introductory essays by leading authorities in the field.
Author: Uldis N. Streips
Publisher: John Wiley & Sons
ISBN: 0471461083
Category : Science
Languages : en
Pages : 673
Get Book Here
Book Description
In accordance with its predecessor, the completely revised and expanded Second Edition of Modern Microbial Genetics focuses on how bacteria and bacteriophage arrange and rearrange their genetic material through mutation, evolution, and genetic exchange to take optimal advantage of their environment. The text is divided into three sections: DNA Metabolism, Genetic Response, and Genetic Exchange. The first addresses how DNA replicates, repairs itself, and recombines, as well as how it may be manipulated. The second section is devoted to how microorganisms interact with their environment, including chapters on sporulation and stress shock, and the final section contains the latest information on classic exchange mechanisms such as transformation and conjugation. Chapters include: * Gene Expression and Its Regulation * Single-Stranded DNA Phages * Genetic Tools for Dissecting Motility and Development of Myxococcus xanthus * Molecular Mechanism of Quorum Sensing * Transduction in Gram-Negative Bacteria * Genetic Approaches in Bacteria with No Natural Genetic Systems The editors also cultivate an attention to global regulatory systems throughout the book, elucidating how certain genes and operons in bacteria, defined as regulons, network and cooperate to suit the needs of the bacterial cell. With clear appreciation for the impact of molecular genomics, this completely revised and updated edition proves that Modern Microbial Genetics remains the benchmark text in its field.
Author: Ronald C. Conaway
Publisher: Raven Press (ID)
ISBN:
Category : Science
Languages : en
Pages : 600
Get Book Here
Book Description
Presents a coherent account of many productive lines of investigation, organized as a series of mini-reviews that focus on major research areas including studies on the structure and mechanisms of action of bacterial, viral, and eukaryotic RNA polymerases, and the transcription factors that control their activities. Each review provides a brief but up-to-date account of the progress of research in a particular area, a discussion of the major issues and questions driving that research, and a brief description of the evolving approaches and technologies used to address those questions. Annotation copyright by Book News, Inc., Portland, OR
Author: Russell F. Doolittle
Publisher: University Science Books
ISBN: 9780935702545
Category : Science
Languages : en
Pages : 118
Get Book Here
Book Description
In these days of facile cloning and rapid DNA sequencing, it is not uncommon for investigators to find themselves with a DNA sequence that may or may not code for a known gene product. The sequence is 'open' when read in an appropriate frame, which is to say that there is a long run of amino acid codons before the appearance of a terminator codon. How can we find out if this 'unidentified reading frame' (URF) really codes for a genuine protein, and how can we identify it if it exists? There are two general strategies, both of which can also be applied to the characterization of any 'open reading frame' (ORF), whether or not it has been 'identified'. The first and simplest approach involves computer searching and analysis; the second employs antibodies raised against synthetic peptides patterned on the sequence of the expected gene product. Both methods have been used with great success by many investigators. Each has, nonetheless, its pitfalls and frustrations. This primer is meant to guide the researcher past those obstacles as much as possible. Graduate students and researchers interested in amino acid sequencing; molecular biologists, biochemists, chemists, and biotechnologists.
Author: Vladimir P. Skulachev
Publisher: Springer Science & Business Media
ISBN: 3642729789
Category : Science
Languages : en
Pages : 453
Get Book Here
Book Description
Membrane bioenergetics is one of the most rapidly growing areas within physico-chemical biology. Main aspects treated in this book include energy conservation and utilization by membrane-linked molecular mechanisms such as intracellular respiration, photosynthesis, transport phenomena, rotation of bacterial flagella, and the regulation of heat production.
Author: Edward A. Birge
Publisher: Springer Science & Business Media
ISBN: 1475719957
Category : Science
Languages : en
Pages : 432
Get Book Here
Book Description
Bacterial genetics has become one of the cornerstones of basic and applied microbiology and has contributed key knowledge for many of the fundamental advances of modern biology. The second edition of this comprehensive yet concise text, first published in 1981, has been thoroughly updated and redesigned to account for new developments in this rapidly expanding field. All of the major topics in modern bacterial and bacteriophage genetics are presented, among them mutations and mutagenesis, genetics of T4 bacteriophage and other intemperate and temperate phages, transduction, transformation, conjugation and plasmids, recombination and repair, probability laws for prokaryote cultures, as well as applied bacterial genetics.
Author: D. A. Hopwood
Publisher: Oxford University Press
ISBN: 019515066X
Category : Medical
Languages : en
Pages : 261
Get Book Here
Book Description
This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.
