Adrenergic Mechanisms in Myocardial Ischemia PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Adrenergic Mechanisms in Myocardial Ischemia PDF full book. Access full book title Adrenergic Mechanisms in Myocardial Ischemia by G. Heuch. Download full books in PDF and EPUB format.
Author: G. Heuch
Publisher: Springer Science & Business Media
ISBN: 3662110385
Category : Medical
Languages : en
Pages : 667
Get Book Here
Book Description
Stress-induced myocardial ischemia is a frequent manifestation of coronary heart disease, and sympathetic activation is an important precipitating and aggravating factor in such stress induced ischemia. However, the complex interplay between the sympathetic initiation of myocardial ischemia, ischemia-induced alterations in sympathetic neurotransmission, as well as changes in adrenoceptor density and post-receptor signal transduction that can occur during ischemia remains incompletely understood. Not only the activation of myocardial fJ adrenoceptors, but also the activation of coronary IX-adrenoceptors can contribute to myocar dial ischemia. However, the role of fJ-adrenoceptor-mediated increases in contractility relative to heart rate in the initiation of ischemia is not clear, and the significance of IX-adrenoceptor mediated changes in coronary vasomotor tone, as well as the responsible IX-adrenoceptor subtypes are highly controversial. Malignant arrhythmias may be triggered by both IX- and fJ-adrenergic mechanisms. Current research in this field is focussed not only on the underlying physiological and pathophysiological mechanisms, but also on clinical treatment strategies, e. g., by fJ-blockade, IX-blockade, bradycardic agents and calcium antagonists. Recent findings were presented and future research directions discussed during the 61" International Titisee Conference, held at the Schwarzwald-Hotel, Titisee, March 29-31, 1990 under the sponsorship of the Boehringer Ingelheim Foundation. Dr. Hasso Schroeder and Dr. Hermann Frohlich deserve special thanks for their generous support and pleasant organization of the meeting. The publication of the proceedings has been made possible by grants from Astra Chemicals, Bayer, ICI, Dr. Karl Thomae, and Upjohn
Author: G. Heuch
Publisher: Springer Science & Business Media
ISBN: 3662110385
Category : Medical
Languages : en
Pages : 667
Get Book Here
Book Description
Stress-induced myocardial ischemia is a frequent manifestation of coronary heart disease, and sympathetic activation is an important precipitating and aggravating factor in such stress induced ischemia. However, the complex interplay between the sympathetic initiation of myocardial ischemia, ischemia-induced alterations in sympathetic neurotransmission, as well as changes in adrenoceptor density and post-receptor signal transduction that can occur during ischemia remains incompletely understood. Not only the activation of myocardial fJ adrenoceptors, but also the activation of coronary IX-adrenoceptors can contribute to myocar dial ischemia. However, the role of fJ-adrenoceptor-mediated increases in contractility relative to heart rate in the initiation of ischemia is not clear, and the significance of IX-adrenoceptor mediated changes in coronary vasomotor tone, as well as the responsible IX-adrenoceptor subtypes are highly controversial. Malignant arrhythmias may be triggered by both IX- and fJ-adrenergic mechanisms. Current research in this field is focussed not only on the underlying physiological and pathophysiological mechanisms, but also on clinical treatment strategies, e. g., by fJ-blockade, IX-blockade, bradycardic agents and calcium antagonists. Recent findings were presented and future research directions discussed during the 61" International Titisee Conference, held at the Schwarzwald-Hotel, Titisee, March 29-31, 1990 under the sponsorship of the Boehringer Ingelheim Foundation. Dr. Hasso Schroeder and Dr. Hermann Frohlich deserve special thanks for their generous support and pleasant organization of the meeting. The publication of the proceedings has been made possible by grants from Astra Chemicals, Bayer, ICI, Dr. Karl Thomae, and Upjohn
Author: Mátyás Szentiványi
Publisher:
ISBN: 9789630526913
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Michitoshi Inoue
Publisher: Springer Science & Business Media
ISBN: 4431683674
Category : Medical
Languages : en
Pages : 330
Get Book Here
Book Description
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Author: Morris Karmazyn
Publisher: Springer Science & Business Media
ISBN: 9783764352691
Category : Medical
Languages : en
Pages : 538
Get Book Here
Book Description
Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.
Author: Gerd Heusch
Publisher: Springer Verlag
ISBN: 9780387913704
Category : Adrenaline
Languages : en
Pages : 376
Get Book Here
Book Description
Author: Naranjan S. Dhalla
Publisher: Springer Science & Business Media
ISBN: 1461503558
Category : Medical
Languages : en
Pages : 564
Get Book Here
Book Description
Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps in is now its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 030915698X
Category : Medical
Languages : en
Pages : 304
Get Book Here
Book Description
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Author: Naranjan S. Dhalla
Publisher: Lippincott Williams & Wilkins
ISBN:
Category : Medical
Languages : en
Pages : 570
Get Book Here
Book Description
Author: Dennis V. P. Cokkinos
Publisher: Springer Science & Business Media
ISBN: 0387286586
Category : Medical
Languages : en
Pages : 212
Get Book Here
Book Description
Effective new treatments of heart disease are based on a refined understanding of cellular function and the heart's response to environmental stresses. Not surprisingly therefore, the field of experimental cardiology has experienced a phase of rapid expo nential growth during the last decade. The acquisition of new knowledge has been so fast that textbooks of cardiology or textbooks of cardiovascular physiology are often hard-pressed to keep up with the most important conceptual advances. Witness the explosive increase in knowledge about signaling pathways of cardiac growth, transcrip tional regulation of cardiac metabolism, hormonal signaling, and the complex responses of the heart to ischemia, reperfusion, or ischemic preconditioning. This book is meant to bridge the gap between original literature and textbook reviews. It brings together inves tigators of various backgrounds who share their expertise in the biology of myocardial ischemia. Each chapter is a self-contained mini-review, but it will soon become apparent to the reader that there is also a common thread: Molecular and cellular cardiology has never been more exciting than now, but ever more exciting times are yet to come. The Editors ACKNOWLEDGEMENTS - Publication of this book was generously supported by Sanofi-Aventis Hellas. - Eikon creative team provided the technical assistance in preparing the manuscripts. - We thank Dr. Bernard Swynghedauw for all his scientific support.
Author: Giuseppe Di Pasquale
Publisher: Springer Science & Business Media
ISBN: 3642766528
Category : Medical
Languages : en
Pages : 224
Get Book Here
Book Description
In the last decade there has been a growing interest in the study of the interactions between the heart and the brain, especially in the field of cerebral ischemia. The interactions between cardiovascular and cerebrovascular diseases are of relevance not only for research investigation, but also for clinical implications in the daily clinical practice. i.e. A wealth of information has been gathered particularly on three topics, cardiovascular consequences of cerebral injuries, cardioembolic stroke, and association of carotid and coronary artery disease. The available information, however, is still sparse and fragmentary mainly because of the lack of commun ication between neurologists and cardiologists. With the aim of improving communication between several disciplines and technologies, we started to organize since 1987 in Bologna, Italy, an international Symposium on heart brain interactions to be held every 3 years. Our intention was to gather prominent clinicians and researchers from outstanding cardiologic and neuro logic institutions actively involved in the study of heart-brain interactions. The ambitious goal has been to fit different pieces of information like in a puzzle. This book originates from the contributions presented at the 2nd Sympo sium which was held in Bologna on November 30-December 1, 1990. The book is subdivided into three sections: I cardiovascular consequences of cerebral damage, II cardiogenic cerebral ischemia, III cerebrovascular and coronary artery disease.
