Author: Karyne Rangel
Publisher: BoD – Books on Demand
ISBN: 0854663711
Category : Medical
Languages : en
Pages : 177
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Book Description
Acinetobacter baumannii is a formidable global pathogen notorious for its widespread drug-resistant nature. It is a major culprit in various infections, particularly targeting immunocompromised individuals in intensive care units (ICUs). A paramount concern associated with this pathogen lies in its remarkable ability to develop resistance to nearly all clinically utilized antibiotics. Furthermore, it exhibits a concerning propensity to disseminate this resistance rapidly, transcending borders and impacting healthcare facilities across diverse economic strata. Of particular focus is the carbapenem-resistant strain of A. baumannii (CRAb). This strain has garnered the top spot on the World Health Organization's (WHO) list of pathogens, necessitating urgent attention for new treatment development. This book delves into numerous studies underscoring the pivotal role of A. baumannii as one of the most impactful bacteria contributing to Healthcare-Associated Infections (HAIs) within the contemporary healthcare landscape.
Author: Ulrike Gerischer
Publisher:
ISBN: 9781913652180
Category :
Languages : en
Pages : 359
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Book Description
This concise volume reviews the most current and topical aspects of Acinetobacter genetics and molecular biology and is aimed at a readership of research scientists, graduate students and other specialists. Expert international authors have contributed chapters on diverse topics including taxonomy, lipopolysaccharides, catabolism of aromatic compounds, transformation systems, transcriptional regulation, applications in biotechnology, the molecular basis for virulence and pathogenicity, molecular epidemiology, and antibiotic resistance. This book is highly recommended for anyone involved in Aci.
Author: E. Bergogne-Berezin
Publisher: CRC Press
ISBN: 1000151727
Category : Medical
Languages : en
Pages : 290
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Book Description
Acinetobacter details the clinical aspects of this bacterium responsible for many infections in hospitalized patients. This reference explains the importance of these organisms, both from the patient's viewpoint and the economic perspective, and provides clinicians with the knowledge they need to control these bacteria.
Author: Juan Carlos Alonso
Publisher: Mdpi AG
ISBN: 9783036506746
Category : Science
Languages : en
Pages : 170
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Book Description
Bacterial toxin-antitoxin (TA) systems, which are ubiquitously present in bacterial genomes, are not essential for normal cell proliferation. The TA systems regulate fundamental cellular processes, facilitate survival under stress conditions, have essential roles in virulence and represent potential therapeutic targets. These genetic TA loci are also shown to be involved in the maintenance of successful multidrug-resistant mobile genetic elements. The TA systems are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition. Type II TA systems encode a labile antitoxin and its stable toxin; degradation of the antitoxin renders a free toxin, which is bacteriostatic by nature. A free toxin generates a reversible state with low metabolic activity (quiescence) by affecting important functions of bacterial cells such as transcription, translation, DNA replication, replication and cell-wall synthesis, biofilm formation, phage predation, the regulation of nucleotide pool, etc., whereas antitoxins are toxin inhibitors. Under stress conditions, the TA systems might form networks. To understand the basis of the unique response of TA systems to stress, the prime causes of the emergence of drug-resistant strains, and their contribution to therapy failure and the development of chronic and recurrent infections, must be known in order to grasp how TA systems contribute to the mechanisms of phenotypic heterogeneity and pathogenesis that will enable the rational development of new treatments for infections caused by pathogens.
Author: Ghassan M. Matar
Publisher: Frontiers Media SA
ISBN: 288945469X
Category :
Languages : en
Pages : 183
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Book Description
Pseudomonas aeruginosa and Acinetobacter baumannii are among the most common non-lactose-fermenting Gram-negative pathogens responsible for hospital-acquired infections, especially in intensive care units (ICUs). The treatment of infections caused by these bacteria is complicated due to the emergence of multi-drug resistance as the two species are noted for their intrinsic resistance to antimicrobial agents and their ability to acquire genetic elements that encode for resistance determinants. In both species, resistance to multiple classes of antimicrobial agents can seriously compromise the ability to treat infected patients, especially the immunocompromised. Consequently, very few antimicrobials remain as treatment options. Mechanisms of resistance in both of these pathogens include the production of β-lactamases and aminoglycoside-modifying enzymes as well as reduced or lack of expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps. To that purpose, the findings of the studies included in this book deal with the prevalence of resistant isolates to various antimicrobial agents in both P. aeruginosa and A. baumannii, their underlying mechanisms of resistance, their virulence factors, their pathogenesis, and prospective treatment options. Special thanks are due to Mr. Bassam El-Hafi for facilitating procedures involved in this publication.
Author: World Health Organization
Publisher:
ISBN: 9789241564748
Category : Medical
Languages : en
Pages : 232
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Book Description
Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.
Author: Busi Siddhardha
Publisher: Springer Nature
ISBN: 9811516952
Category : Science
Languages : en
Pages : 685
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Book Description
This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
Author: Indranil Biswas
Publisher: Humana Press
ISBN: 9781493991174
Category : Medical
Languages : en
Pages : 338
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Book Description
This detailed volume serves clinicians and basic science researchers studying the increasingly antibiotic resistant Gram-negative bacterium Acinetobacter baumannii. Chapters detail microbiological techniques, biochemical techniques, clinical samples, and next generation omics techniques to characterize the organism at the molecular level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Acinetobacter baumannii: Methods and Protocols aims to ensure successful results in the further study of this high priority area of antibiotic study.
Author:
Publisher: Academic Press
ISBN: 0124159761
Category : Science
Languages : en
Pages : 719
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Book Description
The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen Contains new material on antimicrobial resistance and biofilms Covers drinking water and both marine and freshwater recreational bathing waters
Author: Yashar Jalali
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 0
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Book Description
By exhibiting resistance to most known antibiotics or quickly acquiring resistance to antimicrobials it was once susceptible to, Acinetobacter baumannii has attracted increasing attention worldwide since the last decades of the previous century. The resistance abilities of the bacterium were soon shown to be so advanced that it was even able to resist antibiotics that had only just been discovered and used for first time. Utilizing complex mechanisms of resistance, combining different modalities, and achieving new resistant traits established A. baumannii as one of the most clinically important and challenging pathogens of the new century, being categorized by the World Health Organization as a critical priority bacterium for which new antibiotics are urgently needed. After even last-resort, broad-spectrum antibiotics were rendered useless, the fight against this superbug began to be led by the reintroduction of once abandoned antimicrobials, new combination therapies and novel modalities of treatment. In this chapter, we will look at the history and background of Acinetobacter species and then specifically focus on A. baumannii, explaining its clinical importance in detail, reviewing the most recent findings regarding its mechanisms of resistance, latest modalities of treatment and newest areas of research towards opening new frontiers in the management of infections caused by multi-resistant strains of this bacterium.
