Author: T. W. Stone
Publisher: Taylor & Francis
ISBN: 9780748400638
Category : Acetylcholine
Languages : en
Pages : 272
Book Description
Acetylcholine, Sigma Receptors, CCK and Eicosanoids, Neurotoxins
Author: T. W. Stone
Publisher: Taylor & Francis
ISBN: 9780748400638
Category : Acetylcholine
Languages : en
Pages : 272
Book Description
Publisher: Taylor & Francis
ISBN: 9780748400638
Category : Acetylcholine
Languages : en
Pages : 272
Book Description
Aspects of Synaptic Transmission 2
Author: T. W. Stone
Publisher:
ISBN:
Category : Acetylcholine
Languages : en
Pages : 255
Book Description
Publisher:
ISBN:
Category : Acetylcholine
Languages : en
Pages : 255
Book Description
Aspects of Synaptic Transmission: Acetylcholine, sigma receptors, CCK and eicosanoids, neurotoxins
Author: T. W. Stone
Publisher:
ISBN: 9780850668285
Category : Autonomic nervous system
Languages : en
Pages : 404
Book Description
Publisher:
ISBN: 9780850668285
Category : Autonomic nervous system
Languages : en
Pages : 404
Book Description
Alzheimer Disease
Author: Ezio Giacobini
Publisher: Springer Science & Business Media
ISBN: 1461581494
Category : Medical
Languages : en
Pages : 673
Book Description
Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Publisher: Springer Science & Business Media
ISBN: 1461581494
Category : Medical
Languages : en
Pages : 673
Book Description
Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Neuropharmacology of Polyamines
Author: Chris Carter
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 346
Book Description
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields of life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. Polyamines have had a hard time competing for research interest. As anyone who has studied polyamines knows, it is possible to observe some sort of polyamine effects in almost any assay system at high concentrations, and their generality of action has obviously been a deterrent to intensive research. Most of the research is concentrated in the field of cancer and relatively little polyamine research is neuroscience related, although in 1926 spermine (then known as neuridine) was first isolated from brain tissue. Further research revealed the existence of uptake and release mechanisms for brain polyamines, as seen with other substances more commonly accepted as neurotransmitters. Polyamines were also found to lay a regulatory role in cellular calcium homeostasis and to have a metabolism that is deregulated in response to cerebral trauma or ischaemia, and finally to modulate the NMDA receptor. It was this last effect which tipped the balance in favour of intensive research into polyamines in the brain. Despite their ubiquity and demonstrated links with many important physiological regulatory processes, there is no coherent hypothesis to explain their presence or role in cellular physiology. This book does not provide such a hypothesis, but attempts to group the known effects and properties of polyamines as applied to neuroscience and to stimulate interest in this field. The polyamines are deliberately treated as neuromodulators or neurotransmitters with an important and specific function in brain. This assumption is far from proven, but it is hoped that enough interest in this research area will be stimulated which will result in a more precise definition of polyamine function in the future.
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 346
Book Description
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields of life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. Polyamines have had a hard time competing for research interest. As anyone who has studied polyamines knows, it is possible to observe some sort of polyamine effects in almost any assay system at high concentrations, and their generality of action has obviously been a deterrent to intensive research. Most of the research is concentrated in the field of cancer and relatively little polyamine research is neuroscience related, although in 1926 spermine (then known as neuridine) was first isolated from brain tissue. Further research revealed the existence of uptake and release mechanisms for brain polyamines, as seen with other substances more commonly accepted as neurotransmitters. Polyamines were also found to lay a regulatory role in cellular calcium homeostasis and to have a metabolism that is deregulated in response to cerebral trauma or ischaemia, and finally to modulate the NMDA receptor. It was this last effect which tipped the balance in favour of intensive research into polyamines in the brain. Despite their ubiquity and demonstrated links with many important physiological regulatory processes, there is no coherent hypothesis to explain their presence or role in cellular physiology. This book does not provide such a hypothesis, but attempts to group the known effects and properties of polyamines as applied to neuroscience and to stimulate interest in this field. The polyamines are deliberately treated as neuromodulators or neurotransmitters with an important and specific function in brain. This assumption is far from proven, but it is hoped that enough interest in this research area will be stimulated which will result in a more precise definition of polyamine function in the future.
British Book News
Author: British Council
Publisher:
ISBN:
Category : Best books
Languages : en
Pages : 868
Book Description
Includes no. 53a: British wartime books for young people.
Publisher:
ISBN:
Category : Best books
Languages : en
Pages : 868
Book Description
Includes no. 53a: British wartime books for young people.
Index of Conference Proceedings
Author: British Library. Document Supply Centre
Publisher:
ISBN:
Category : Congresses and conventions
Languages : en
Pages : 990
Book Description
Publisher:
ISBN:
Category : Congresses and conventions
Languages : en
Pages : 990
Book Description
The Journal of Neuroscience
Author:
Publisher:
ISBN:
Category : Neurology
Languages : en
Pages : 1022
Book Description
Publisher:
ISBN:
Category : Neurology
Languages : en
Pages : 1022
Book Description
Whitaker's Books in Print
Author:
Publisher:
ISBN:
Category : Bibliography, National
Languages : en
Pages : 2954
Book Description
Publisher:
ISBN:
Category : Bibliography, National
Languages : en
Pages : 2954
Book Description
Neurotransmitters, Drugs and Brain Function
Author: Roy Webster
Publisher: John Wiley & Sons
ISBN: 9780471978190
Category : Medical
Languages : de
Pages : 550
Book Description
Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.
Publisher: John Wiley & Sons
ISBN: 9780471978190
Category : Medical
Languages : de
Pages : 550
Book Description
Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.