A Mathematical Model of the Impact of Novel Treatments on the Ab Burden in the Alzheimer's Brain, Csf and Plasma (Classic Reprint) PDF Download
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Author: Lawrence M. Wein
Publisher: Forgotten Books
ISBN: 9780365738060
Category : Science
Languages : en
Pages : 66
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Book Description
Excerpt from A Mathematical Model of the Impact of Novel Treatments on the Ab Burden in the Alzheimer's Brain, Csf and Plasma Our model is an infinite system of nonlinear ordinary differential equations that are related to a large class of models used to study actin formation, polymer chemistry, and galaxy formation, crystallization and cloud formation19_20. While the polymerization and depolymerization processes we employ are specialized to AD and are less general than many considered in the literature, the main novelty of our model is the incorporation of multiple compartments with sources (production) and sinks (loss). About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
Author: Lawrence M. Wein
Publisher: Forgotten Books
ISBN: 9780365738060
Category : Science
Languages : en
Pages : 66
Get Book Here
Book Description
Excerpt from A Mathematical Model of the Impact of Novel Treatments on the Ab Burden in the Alzheimer's Brain, Csf and Plasma Our model is an infinite system of nonlinear ordinary differential equations that are related to a large class of models used to study actin formation, polymer chemistry, and galaxy formation, crystallization and cloud formation19_20. While the polymerization and depolymerization processes we employ are specialized to AD and are less general than many considered in the literature, the main novelty of our model is the incorporation of multiple compartments with sources (production) and sinks (loss). About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
Author: Lawrence M. Wein
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
With the advent of novel therapies for AD, there is a pressing need for biomarkers that are easy to monitor, such as the amyloid-beta levels in the cerebrospinal fluid (CSF) and plasma. To gain a better understanding of the explanatory power of these biomarkers, we formulate and analyze a compaxtmental mathematical model for the amyloid-beta accumulation in the brain, CSF and plasma throughout the course of Alzheimer's treatment. Our analysis reveals that the total amyloid-beta burden in the brain is dictated by a unitless quantity called the polymerization ratio, which is the product of the production and elongation rates divided by the product of the fragmentation and loss rates. In this ratio, the production rate and loss rate include a source and sink term, respectively, related to the intercompaxtmental transport. Our results suggest that production inhibitors are likely to reduce the amyloid-beta levels in all three compartments. In contrast, agents that ingest monomers off of polymers, or that increase fragmentation or block elongation, may also reduce amyloid-beta burden in the brain, but may produce little change in or even transiently increase CSF and plasma amyloid-beta levels. Hence, great care must be taken when interpreting these biomarkers.
Author: Lawrence M. Wein
Publisher: Palala Press
ISBN: 9781379090991
Category : History
Languages : en
Pages : 66
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Book Description
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Author: Lawrence M Wein
Publisher: Palala Press
ISBN: 9781342154170
Category :
Languages : en
Pages : 66
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Book Description
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
![A Mathematical Model of the Impact of Novel Treatments on the A[beta] Burden in the Alzheimer's Brain, CSF and Plasma PDF](https://books.google.com/books/content/images/frontcover/CuVpNwAACAAJ?fife=w80-h100)
Author: Lawrence M. Wein
Publisher:
ISBN:
Category :
Languages : en
Pages : 60
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Book Description
With the advent of novel therapies for AD, there is a pressing need for biomarkers that are easy to monitor, such as the amyloid-beta levels in the cerebrospinal fluid (CSF) and plasma. To gain a better understanding of the explanatory power of these biomarkers, we formulate and analyze a compaxtmental mathematical model for the amyloid-beta accumulation in the brain, CSF and plasma throughout the course of Alzheimer's treatment. Our analysis reveals that the total amyloid-beta burden in the brain is dictated by a unitless quantity called the polymerization ratio, which is the product of the production and elongation rates divided by the product of the fragmentation and loss rates. In this ratio, the production rate and loss rate include a source and sink term, respectively, related to the intercompaxtmental transport. Our results suggest that production inhibitors are likely to reduce the amyloid-beta levels in all three compartments. In contrast, agents that ingest monomers off of polymers, or that increase fragmentation or block elongation, may also reduce amyloid-beta burden in the brain, but may produce little change in or even transiently increase CSF and plasma amyloid-beta levels. Hence, great care must be taken when interpreting these biomarkers. Keywords: amyloid beta, mathematical model.
![The Impact of Novel Treatments on A[beta] Burden in Alzheimer's Disease PDF](https://books.google.com/books/content/images/frontcover/_EWnGwAACAAJ?fife=w80-h100)
Author: David Lee Craft
Publisher:
ISBN:
Category :
Languages : en
Pages : 62
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Book Description
Author: David Lee Craft
Publisher:
ISBN:
Category :
Languages : en
Pages : 62
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Book Description
Author: David Lee Craft
Publisher: Palala Press
ISBN: 9781342020796
Category :
Languages : en
Pages : 68
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Book Description
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Author: S. Govoni
Publisher: Springer Science & Business Media
ISBN: 8847021499
Category : Medical
Languages : en
Pages : 311
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Book Description
To a certain extent the dementias have been forgotten diseases until just recen tly when they were brought to the attention of the general public and health authorities as a result of the increasing number of cases in the aging popula tion, especially among famous people, and because of the efforts of private foundations. The goals of the present volume are to present the dementias to health prac titioners, to provide some basic information on their epidemiology and biolo gical basis and to discuss the diagnostic and clinical problems that physicians and institutions face when caring for demented patients. This book explores the various types of dementias and is not limited to Alzheimer's disease although, as expected, more information is available and presented on this pathology. On the other hand, a few fundamental questions on dementia can only be answe red through a comparison of the various forms. Examples of such questions are the following: Is the loss of cerebral tissue sufficient to cause dementia? Are there thresholds or is there a continuous progression toward the irreversible development of dementia? Are there common pathways in the dementing pro cess? Are there common risk factors? Comparative analysis allows the common and distinctive patterns of the various dementias to be defined, ultimately lea ding to more focused therapeutic interventions.
Author: Shamim I. Ahmad
Publisher: Springer Science & Business Media
ISBN: 1461406536
Category : Medical
Languages : en
Pages : 421
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Book Description
The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
