A Mathematical Analysis of a Model of Drug Action on Intracellular Calcium Dynamics PDF Download
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Author: Marah Townzen Funk
Publisher:
ISBN:
Category :
Languages : en
Pages : 50
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Book Description
Author: Marah Townzen Funk
Publisher:
ISBN:
Category :
Languages : en
Pages : 50
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Book Description
Author: Hans Dierckx
Publisher: Frontiers Media SA
ISBN: 2889630676
Category :
Languages : en
Pages : 276
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Book Description
Author: Susan Mertins
Publisher: Frontiers Media SA
ISBN: 283255346X
Category : Science
Languages : en
Pages : 137
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Book Description
The vast amount of knowledge in Cell Signaling gathered through reductionist efforts and omics technology is poised to approach a Systems Biology understanding of precise representations of cell structure and function and predictions at multi-scale levels despite the complexity. Super-resolution microscopy and single cell analysis are also providing opportunities to explore both spatial and temporal landscapes. Notably, many basic biological processes have been studied capturing mechanistic detail with the goal to understand cellular proliferation and differentiation, gene regulation, morphogenesis, metabolism, and cell-cell communication. Similarly, at the intracellular level, addressing functions such as self-assembly, phase separation, and transport is leading to insights not readily understood as linear pathways. Therefore, network-based mathematical modeling, delineating dynamic biochemical reactions through ordinary and partial differential equations, promises to discover emergent biological properties not heretofore expected.
Author: Jose Jalife
Publisher: Elsevier Health Sciences
ISBN: 0323757464
Category : Medical
Languages : en
Pages : 1709
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Book Description
Fully updated from cover to cover, Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. Packs each chapter with the latest information necessary for optimal basic research as well as patient care. Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. Includes 47 new standalone chapters that are organized into discrete topics for improved access. Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. Recipient of a 2018 Highly Commended award from the British Medical Association.
Author: Gerhard Holzapfel
Publisher: Springer Science & Business Media
ISBN: 9400754639
Category : Technology & Engineering
Languages : en
Pages : 406
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Book Description
This book contains a collection of papers that were presented at the IUTAM Symposium on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics
Author: James Keener
Publisher: Springer Science & Business Media
ISBN: 038775847X
Category : Mathematics
Languages : en
Pages : 1067
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Book Description
Divided into two volumes, the book begins with a pedagogical presentation of some of the basic theory, with chapters on biochemical reactions, diffusion, excitability, wave propagation and cellular homeostasis. The second, more extensive part discusses particular physiological systems, with chapters on calcium dynamics, bursting oscillations and secretion, cardiac cells, muscles, intercellular communication, the circulatory system, the immune system, wound healing, the respiratory system, the visual system, hormone physiology, renal physiology, digestion, the visual system and hearing. New chapters on Calcium Dynamics, Neuroendocrine Cells and Regulation of Cell Function have been included. Reviews from first edition: Keener and Sneyd's Mathematical Physiology is the first comprehensive text of its kind that deals exclusively with the interplay between mathematics and physiology. Writing a book like this is an audacious act! -Society of Mathematical Biology Keener and Sneyd's is unique in that it attempts to present one of the most important subfields of biology and medicine, physiology, in terms of mathematical "language", rather than organizing materials around mathematical methodology. -SIAM review
Author: Peter P. Nanasi
Publisher: Frontiers Media SA
ISBN: 2889639967
Category : Medical
Languages : en
Pages : 241
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: Axel Sandvig
Publisher: Frontiers Media SA
ISBN: 2832513247
Category : Science
Languages : en
Pages : 171
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Book Description
Author: G. Bard Ermentrout
Publisher: Springer Science & Business Media
ISBN: 0387877088
Category : Mathematics
Languages : en
Pages : 434
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Book Description
This book applies methods from nonlinear dynamics to problems in neuroscience. It uses modern mathematical approaches to understand patterns of neuronal activity seen in experiments and models of neuronal behavior. The intended audience is researchers interested in applying mathematics to important problems in neuroscience, and neuroscientists who would like to understand how to create models, as well as the mathematical and computational methods for analyzing them. The authors take a very broad approach and use many different methods to solve and understand complex models of neurons and circuits. They explain and combine numerical, analytical, dynamical systems and perturbation methods to produce a modern approach to the types of model equations that arise in neuroscience. There are extensive chapters on the role of noise, multiple time scales and spatial interactions in generating complex activity patterns found in experiments. The early chapters require little more than basic calculus and some elementary differential equations and can form the core of a computational neuroscience course. Later chapters can be used as a basis for a graduate class and as a source for current research in mathematical neuroscience. The book contains a large number of illustrations, chapter summaries and hundreds of exercises which are motivated by issues that arise in biology, and involve both computation and analysis. Bard Ermentrout is Professor of Computational Biology and Professor of Mathematics at the University of Pittsburgh. David Terman is Professor of Mathematics at the Ohio State University.
Author: Vito Di Maio
Publisher: Frontiers Media SA
ISBN: 2889630730
Category :
Languages : en
Pages : 160
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Book Description
Any brain activity relies on the interaction of thousands of neurons, each of which integrating signals from thousands of synapses. While neurons are undoubtedly the building blocks of the brain, synapses constitute the main loci of information transfer that lead to the emergence of neuronal code. Investigating synaptic transmission constitutes a multi-faceted challenge that brings together a large number of techniques and expertise ranging from experimental to computational approaches, bringing together paradigms spanning from molecular to neural network level. In this book, we have collected a series of articles that present foundational work aimed at shedding much-needed light on brain information processing, synaptic transmission and neural code formation. Some articles present analyses of regulatory mechanisms underlying neural code formation and its elaboration at the molecular level, while others use computational and modelling approaches to investigate, at synaptic, neuronal and inter-neuronal level, how the different mechanisms involved in information processing interact to generate effects like long-term potentiation (LTP), which constitutes the cellular basis of learning and memory. This collection, although not exhaustive, aims to present a framework of the most used investigational paradigms and showcase results that may, in turn, generate novel hypotheses and ideas for further studies and investigations.
