2021 WHO Classification of Pediatric Brain Tumors: A Final Wedding Between Morphology and Molecular Biology? PDF Download
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Author: Angela Mastronuzzi
Publisher: Frontiers Media SA
ISBN: 2832549292
Category : Science
Languages : en
Pages : 117
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Book Description
Tumors of the central nervous system (CNS) are a dramatic health problem due to their high morbidity and mortality in all ages. In the pediatric population, brain tumors constitute the second most common cancer diagnosed worldwide each year, accounting for approximately 25% of childhood cancers. Although there has been a moderate increase in survival rates for children with CNS tumors over the past decades, CNS tumors remain the second leading cause of cancer death in children less than 20 years of age. The fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5) was recently released. This builds on the 2016 WHO CNS tumor update, which for the first time incorporated molecular data with histology in classifying CNS tumors. The changes in the WHO CNS5 group tumors into more biologically and molecularly defined entities with better characterized natural histories, as well as introducing new tumor types and subtypes, especially in the pediatric population. Most importantly, these updated classifications will enable clinicians to have a better understanding of the prognosis and optimal therapy for patients with specific CNS tumors. Therefore, optimizing the treatment of childhood CNS tumors remains a tremendously challenging task, requiring a multidisciplinary approach involving many pediatric specialists as well as the support of molecular biologists and pharmacologists.
Author: Angela Mastronuzzi
Publisher: Frontiers Media SA
ISBN: 2832549292
Category : Science
Languages : en
Pages : 117
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Book Description
Tumors of the central nervous system (CNS) are a dramatic health problem due to their high morbidity and mortality in all ages. In the pediatric population, brain tumors constitute the second most common cancer diagnosed worldwide each year, accounting for approximately 25% of childhood cancers. Although there has been a moderate increase in survival rates for children with CNS tumors over the past decades, CNS tumors remain the second leading cause of cancer death in children less than 20 years of age. The fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5) was recently released. This builds on the 2016 WHO CNS tumor update, which for the first time incorporated molecular data with histology in classifying CNS tumors. The changes in the WHO CNS5 group tumors into more biologically and molecularly defined entities with better characterized natural histories, as well as introducing new tumor types and subtypes, especially in the pediatric population. Most importantly, these updated classifications will enable clinicians to have a better understanding of the prognosis and optimal therapy for patients with specific CNS tumors. Therefore, optimizing the treatment of childhood CNS tumors remains a tremendously challenging task, requiring a multidisciplinary approach involving many pediatric specialists as well as the support of molecular biologists and pharmacologists.
Author: Katrin Scheinemann
Publisher: Springer
ISBN: 9783031620164
Category : Medical
Languages : en
Pages : 0
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Book Description
While the first edition of this book provided a succinct introduction to pediatric neuro-oncology, biological knowledge of childhood CNS tumors has “exploded” over the past few years and a new edition of this textbook is needed to keep it up-to-date. This updated edition will include chapters on cancer predisposition in children with brain tumors, gliomas, embryonal brain tumors, ependymoma, CNS-GCT, targeted therapies in pediatric brain tumors, and long-term sequelae. New developments covered include the following: - Techniques like DNA methylation have improved the diagnostic process, and have led to an integrated diagnosis of histology, ICH and methylation. - Tumor pathways have been detected, which defines more subgroups within a tumor entity, and results in more individualized treatment for the patient. - Therapeutic options outside the standard combination of surgery, chemotherapy, and radiation have either been implemented within the last years, or are currently under consideration. This book will be aimed at pediatric oncologists and neurooncologists, neurosurgeons, radiation oncologists. Chapters detailing quality of life and supportive care will make this 2nd edition a useful resource for nurses, social workers, physiotherapists, and occupational therapists alike.
Author: Aamir Ahmad
Publisher: Springer Nature
ISBN: 3030203018
Category : Medical
Languages : en
Pages : 427
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Book Description
Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.
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Category : Dental public health
Languages : en
Pages : 32
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Book Description
Author: Simon Bailey
Publisher: Oxford University Press, USA
ISBN: 0199299676
Category : Medical
Languages : en
Pages : 624
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Book Description
While survival rates for children with cancer have increased in recent times, the increased use of more aggressive therapies has brought with it significant adverse effects. Therefore, the aim of pediatric oncologists has become to achieve "cure at least cost" by the appropriate reduction of the intensity and/or duration of treatment in carefully identified good prognosis patients. By comprehensively covering these issues, this handbook aims to provide residents in pediatric hematology and oncology, as well as staff in related medical or other healthcare disciplines, with an easily accessible source of information about the basic principles of childhood cancer and leukemia, as well as much of the more detailed specialist knowledge required to care for children with these conditions. Divided into sections to allow quick access to the necessary information, the handbook covers general principles of diagnosis and treatment, short and long term care, and oncological emergencies before moving on to chapters on specific disease. Normal values and useful websites are also included for reference.
Author: Ralph Fasold
Publisher: Cambridge University Press
ISBN: 0521847680
Category : Language Arts & Disciplines
Languages : en
Pages : 481
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Book Description
This accessible textbook offers balanced and uniformly excellent coverage of modern linguistics.
Author: U. S. Department Justice
Publisher: Createspace Independent Publishing Platform
ISBN: 9781500674151
Category :
Languages : en
Pages : 0
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Book Description
The idea of The Fingerprint Sourcebook originated during a meeting in April 2002. Individuals representing the fingerprint, academic, and scientific communities met in Chicago, Illinois, for a day and a half to discuss the state of fingerprint identification with a view toward the challenges raised by Daubert issues. The meeting was a joint project between the International Association for Identification (IAI) and West Virginia University (WVU). One recommendation that came out of that meeting was a suggestion to create a sourcebook for friction ridge examiners, that is, a single source of researched information regarding the subject. This sourcebook would provide educational, training, and research information for the international scientific community.
Author: Robbie Duschinsky
Publisher: Oxford University Press
ISBN: 0198842066
Category : Medical
Languages : en
Pages : 641
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Book Description
This is an open access title available under the terms of a [CC BY-NC-ND 4.0 International] licence. It is free to read at Oxford Clinical Psychology Online and offered as a free PDF download from OUP and selected open access locations. Attachment theory is among the most popular theories of human socioemotional development, with a global research community and widespread interest from clinicians, child welfare professionals, educationalists and parents. It has been considered "one of the most generative contemporary ideas" about family life in modern society. It is one of the last of the grand theories of human development that still retains an active research tradition. Attachment theory and research speak to fundamental questions about human emotions, relationships and development. They do so in terms that feel experience-near, with a remarkable combination of intuitive ideas and counter-intuitive assessments and conclusions. Over time, attachment theory seems to have become more, rather than less, appealing and popular, in part perhaps due to alignment with current concern with the lifetime implications of early brain development Cornerstones of Attachment Research re-examines the work of key laboratories that have contributed to the study of attachment. In doing so, the book traces the development in a single scientific paradigm through parallel but separate lines of inquiry. Chapters address the work of Bowlby, Ainsworth, Main and Hesse, Sroufe and Egeland, and Shaver and Mikulincer. Cornerstones of Attachment Research utilises attention to these five research groups as a lens on wider themes and challenges faced by attachment research over the decades. The chapters draw on a complete analysis of published scholarly and popular works by each research group, as well as much unpublished material.
Author: Daniel Green
Publisher: CRC Press
ISBN: 0340808039
Category : Medical
Languages : en
Pages : 437
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Book Description
The treatment of childhood cancer has become increasingly successful over the last forty years, and during the last two decades in particular, and the overall cure rate is now 60-70%. This, in turn, has introduced new issues for the clinician as the number of long-term survivors has increased. Some of the therapies that have contributed most to the improvement in survival are now known to have serious consequences for the patient in later life, and many survivors will be affected by physical, educational and psychological disability to a lesser or greater degree. This definitive reference brings together all aspects of long-term effects of treatment for cancer during childhood in a single comprehensive volume. International in perspective, the book is structured according to complication rather than original site of malignancy for ease of reference. Topics covered include problems in the neurological system and special senses of sight and sound, cardiovascular, respiratory, gastrointestinal, urological and musculoskeletal complications, effects on the endocrine system and, in particular, future fertility, and secondary cancers. The book also reviews in detail the important issues of quality of life, prevention initiatives and strategies for long-term follow up. Key point summaries are included throughout, and the references are annotated to guide the reader quickly to seminal primary papers and key review articles. With an accessible and consistent approach throughout, Late Effects of Childhood Cancer is an invaluable source of information and guidance for pediatric oncologists, who need to keep fully informed in order to advise patients and their parents appropriately, and also for pediatric and adult endocrinologists, adult oncologists and other physicians to whom the patient with late effects may initially present.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309121787
Category : Medical
Languages : en
Pages : 488
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Book Description
Depression is a widespread condition affecting approximately 7.5 million parents in the U.S. each year and may be putting at least 15 million children at risk for adverse health outcomes. Based on evidentiary studies, major depression in either parent can interfere with parenting quality and increase the risk of children developing mental, behavioral and social problems. Depression in Parents, Parenting, and Children highlights disparities in the prevalence, identification, treatment, and prevention of parental depression among different sociodemographic populations. It also outlines strategies for effective intervention and identifies the need for a more interdisciplinary approach that takes biological, psychological, behavioral, interpersonal, and social contexts into consideration. A major challenge to the effective management of parental depression is developing a treatment and prevention strategy that can be introduced within a two-generation framework, conducive for parents and their children. Thus far, both the federal and state response to the problem has been fragmented, poorly funded, and lacking proper oversight. This study examines options for widespread implementation of best practices as well as strategies that can be effective in diverse service settings for diverse populations of children and their families. The delivery of adequate screening and successful detection and treatment of a depressive illness and prevention of its effects on parenting and the health of children is a formidable challenge to modern health care systems. This study offers seven solid recommendations designed to increase awareness about and remove barriers to care for both the depressed adult and prevention of effects in the child. The report will be of particular interest to federal health officers, mental and behavioral health providers in diverse parts of health care delivery systems, health policy staff, state legislators, and the general public.
