Viability of Human Uterine Transplant PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Viability of Human Uterine Transplant PDF full book. Access full book title Viability of Human Uterine Transplant by Jewel Sawyer. Download full books in PDF and EPUB format.
Author: Jewel Sawyer
Publisher:
ISBN:
Category :
Languages : en
Pages : 90
Get Book Here
Book Description
Problem: Uterine factor infertility is most commonly a result of congenital malformations or previous hysterectomy which leaves women without a functional uterus. Currently, the only options available for this form of infertility are adoption or surrogacy; however, they may not be suitable for women with political or religious prohibitions or those who desperately desire to conceive and carry their own biological children. Therefore, uterus transplant may be an option for these women if organ transplantation is acceptable. To date, there have been various animal studies but only one human trial that examines whether uterine transplant can be successfully performed. The purpose of this literature review is to assess if a surgical technique has been developed that could lead to viable human uterine transplant in the future. Methods: A literature search regarding uterine transplantation over the past ten years was performed in the Weill Cornell Medical College Online library. Search terms used include "uterine transplant", "human" and "uterine transplant", "uterus" and" transplant", "human uterine transplant", "infertility" and "transplant", and "uterine factor infertility". Results: Every study analyzed concluded that uterine transplantation could be successfully performed if a modified technique was employed. It was also found that there are specific markers of rejection such as an increase in neutrophils that could be assessed in order to offset the rejection pattern with the use of adequate immunosuppression. Conclusions: Further research on the use of elongated vascular pedicles, adequate uterine support and immunotherapy will likely significantly improve uterine transplant viability.
Author: Jewel Sawyer
Publisher:
ISBN:
Category :
Languages : en
Pages : 90
Get Book Here
Book Description
Problem: Uterine factor infertility is most commonly a result of congenital malformations or previous hysterectomy which leaves women without a functional uterus. Currently, the only options available for this form of infertility are adoption or surrogacy; however, they may not be suitable for women with political or religious prohibitions or those who desperately desire to conceive and carry their own biological children. Therefore, uterus transplant may be an option for these women if organ transplantation is acceptable. To date, there have been various animal studies but only one human trial that examines whether uterine transplant can be successfully performed. The purpose of this literature review is to assess if a surgical technique has been developed that could lead to viable human uterine transplant in the future. Methods: A literature search regarding uterine transplantation over the past ten years was performed in the Weill Cornell Medical College Online library. Search terms used include "uterine transplant", "human" and "uterine transplant", "uterus" and" transplant", "human uterine transplant", "infertility" and "transplant", and "uterine factor infertility". Results: Every study analyzed concluded that uterine transplantation could be successfully performed if a modified technique was employed. It was also found that there are specific markers of rejection such as an increase in neutrophils that could be assessed in order to offset the rejection pattern with the use of adequate immunosuppression. Conclusions: Further research on the use of elongated vascular pedicles, adequate uterine support and immunotherapy will likely significantly improve uterine transplant viability.
Author: Mats Brännström
Publisher: Springer Nature
ISBN: 3319941623
Category : Health & Fitness
Languages : en
Pages : 226
Get Book Here
Book Description
This book discusses all aspects of the uterus transplantation procedure in women who are childless because of a dysfunctional or missing uterus, from initial pre-operative investigations to follow-up after the uterine graft has been removed. All the international experts who are engaged in clinical activities and/or research in this field have contributed one or more of the book’s chapters. Since the first live birth following uterus transplantation was reported in Sweden in September 2014, the field has been rapidly evolving around the globe: the first cases in USA, Germany, China, Brazil, and Czech Republic were performed in 2016 and several other centres are preparing for clinical trials of uterus transplantation. Uterus transplantation is a subject that attracts the attention of many bioethicists, and like all other major procedures in transplantation surgery and assisted reproduction techniques, it is a complex process that requires a multidisciplinary team if it is to be successful. As such the book is a valuable resource not only for clinicians from many disciplines, but also for nurses, ethicists, psychologists and researchers.
Author: David Price
Publisher: Routledge
ISBN: 135191345X
Category : Law
Languages : en
Pages : 605
Get Book Here
Book Description
Organ transplantation has been one of the miracles of modern-day medicine but, in addition to presenting enormous technical and clinical challenges, it throws up major ethical and legal issues principally from the perspective of the donor. Evolving capabilities in the spheres of both organ and tissue transplantation, coupled with rapidly-escalating demand, assert consistent and critical pressure on our ethical and legal principles and frameworks, including the expansion of the potential donor pool beyond the conventional categories of donor. This volume brings together seminal papers analyzing such matters in the context of an ever-increasingly important area of clinical practice.
Author: Peter M. Fayers
Publisher: John Wiley & Sons
ISBN: 1118699459
Category : Medical
Languages : en
Pages : 460
Get Book Here
Book Description
Quality of life studies form an essential part of the evaluation of any treatment. Written by two authors who are well respected within this field, Quality of Life: The Assessment, Analysis and Interpretation of Patient-reported Outcomes, Second Edition lays down guidelines on assessing, analysing and interpreting quality of life data. The new edition of this standard book has been completely revised, updated and expanded to reflect many methodological developments emerged since the publication of the first edition. Covers the design of instruments, the practical aspects of implementing assessment, the analyses of the data, and the interpretation of the results Presents all essential information on Quality of Life Research in one comprehensive volume Explains the use of qualitative and quantitative methods, including the application of basic statistical methods Includes copious practical examples Fills a need in a rapidly growing area of interest New edition accommodates significant methodological developments, and includes chapters on computer adaptive testing and item banking, choosing an instrument, systematic reviews and meta analysis This book is of interest for everyone involved in quality of life research, and it is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and practitioners in the fields of cancer and other chronic diseases. Reviews of the First Edition – Winner of the first prize in the Basis of Medicine Category of the BMA Medical Book Competition 2001: “This book is highly recommended to clinicians who are actively involved in the planning, analysis and publication of QoL research.” CLINICAL ONCOLOGY “This book is highly recommended reading.” QUALITY OF LIFE RESEARCH
Author: Jacques Donnez
Publisher: Cambridge University Press
ISBN: 1139496123
Category : Medical
Languages : en
Pages : 569
Get Book Here
Book Description
The specialty of fertility preservation offers patients with cancer, who are rendered infertile by chemo- and radiotherapy, the opportunity to realize their reproductive potential. This gold-standard publication defines the specialty. The full range of techniques and scientific concepts is covered in detail, and the author team includes many of the world's leading experts in the field. The book opens with introductions to fertility preservation in both cancer and non-cancer patients, followed by cancer biology, epidemiology and treatment, and reproductive biology and cryobiology. Subsequent sections cover fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of both ovarian tissue and the whole ovary, and in-vitro follicle growth and maturation. Concluding chapters address future technologies, as well as ethical, legal and religious issues. Richly illustrated throughout, this is a key resource for all clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.
Author: Vassyl A. Lonchyna
Publisher: Springer Nature
ISBN: 3030846253
Category : Medical
Languages : en
Pages : 743
Get Book Here
Book Description
This book provides a detailed guide to the ethical considerations involved when making decisions in surgery. Chapters feature a uniform format, which feature a case that represents a real-life problem, discussion of the medical indications of that issue, the latest available medical solutions, and related ethical considerations. In some cases, more in-depth debate is provided on why a particular decision should or should not be made based-upon ethical principles. Information boxes containing key statements and relevant data in clear easy-to-digest tables facilitates the reader in being able to assimilate the most important points covered in each chapter. Difficult Decisions in Surgical Ethics: An Evidence-Based Approach is a thorough review of ethical considerations in a range of surgical scenarios encompassing both adult and pediatric topics, training surgical residents, ethical care during a pandemic, critical care, palliative care, sensitivity to religious and ethnic mores, clinical research, and innovation. It is intended to be a vital resource for practicing and trainee surgeons seeking a comprehensive up-to-date resource on ethical topics in surgical practice. The work is part of the Difficult Decisions in Surgery series covering a range of surgical specialties.
Author: The Royal Society
Publisher: National Academies Press
ISBN: 0309671132
Category : Medical
Languages : en
Pages : 239
Get Book Here
Book Description
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Author: Mohammed Ali Al-Bar
Publisher: Springer
ISBN: 3319184288
Category : Medical
Languages : en
Pages : 273
Get Book Here
Book Description
This book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). Biomedical topics are presented and ethical issues related to topics such as genetic testing, assisted reproduction and organ transplantation are discussed. Whereas these natural sources are God’s special gifts to human beings, God’s revelation as given to the prophets is the supernatural source of divine guidance through which human communities have been guided at all times through history. The second part of the book concentrates on the objectives of Islamic religious practice – the maqa' sid – which include: Preservation of Faith, Preservation of Life, Preservation of Mind (intellect and reason), Preservation of Progeny (al-nasl) and Preservation of Property. Lastly, the third part of the book discusses selected topical issues, including abortion, assisted reproduction devices, genetics, organ transplantation, brain death and end-of-life aspects. For each topic, the current medical evidence is followed by a detailed discussion of the ethical issues involved.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309076374
Category : Science
Languages : en
Pages : 295
Get Book Here
Book Description
Human reproductive cloning is an assisted reproductive technology that would be carried out with the goal of creating a newborn genetically identical to another human being. It is currently the subject of much debate around the world, involving a variety of ethical, religious, societal, scientific, and medical issues. Scientific and Medical Aspects of Human Reproductive Cloning considers the scientific and medical sides of this issue, plus ethical issues that pertain to human-subjects research. Based on experience with reproductive cloning in animals, the report concludes that human reproductive cloning would be dangerous for the woman, fetus, and newborn, and is likely to fail. The study panel did not address the issue of whether human reproductive cloning, even if it were found to be medically safe, would beâ€"or would not beâ€"acceptable to individuals or society.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309179602
Category : Medical
Languages : en
Pages : 112
Get Book Here
Book Description
It is widely understood that stem cell treatments have the potential to revolutionize medicine. Because of this potential, in 2004 California voters approved Proposition 71 to set up a 10-year, $3 billion program to fund research on stem cells. Under the direction of the California Institute for Regenerative Medicine, this program will pay to build facilities for stem cell research and will fund doctors and scientists to carry out research with the ultimate goal of helping to develop therapies based on stem cells. For this research to move forward, however, will require a steady supply of stem cells, particularly human embryonic stem cells. Those stem cells are collected from developing human embryos created from eggs-or oocytes-harvested from the ovaries of female donors. Thus much of the promise of stem cells depends on women choosing to donate oocytes to the research effort. The oocyte donation process is not without risk, however. Donors are given doses of hormones to trigger the production of more eggs than would normally be produced, and this hormone treatment can have various side effects. Once the eggs have matured in the ovary, they must be retrieved via a surgical procedure that is typically performed under anesthesia, and both the surgery and the anesthesia carry their own risks. Furthermore, given the very personal nature of egg donation, the experience may carry psychological risks for some women as well. With this in mind, in 2006 the California Institute for Regenerative Medicine contracted with the National Academies to organize a workshop that would bring together experts from various areas to speak about the potential risks of oocyte donation and to summarize what is known and what needs to be known about this topic. The Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research was formed to plan the workshop, which was held in San Francisco on September 28, 2006. This report is a summary and synthesis of that workshop.
