Tumor microenvironment, immunotherapy, and drug resistance in breast and gastrointestinal cancer PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Tumor microenvironment, immunotherapy, and drug resistance in breast and gastrointestinal cancer PDF full book. Access full book title Tumor microenvironment, immunotherapy, and drug resistance in breast and gastrointestinal cancer by Shaoquan Zheng. Download full books in PDF and EPUB format.
Author: Shaoquan Zheng
Publisher: Frontiers Media SA
ISBN: 2832534694
Category : Medical
Languages : en
Pages : 156
Get Book
Book Description
Author: Shaoquan Zheng
Publisher: Frontiers Media SA
ISBN: 2832534694
Category : Medical
Languages : en
Pages : 156
Get Book
Book Description
Author: Xiaofang Che
Publisher: Frontiers Media SA
ISBN: 2832526101
Category : Medical
Languages : en
Pages : 212
Get Book
Book Description
Gastrointestinal (GI) cancers, including gastric cancer, colon cancer, liver cancer, esophageal cancer, and pancreatic cancer, seriously threaten the health of human beings worldwide with a high rate of morbidity and mortality. The clinical successes achieved with immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 and CTLA-4 have opened a new cancer therapy era and brought new hope to cancer patients. However, the overall response rate (ORR) of ICI monotherapy in the non-selective population is only about 20%, in which some patients subsequently develop immunotherapy resistance. Moreover, the remaining 70-80% of patients displayed primary resistance to ICIs, and a few patients even experienced hyper progression disease (HPD). Although PD-L1 expression, mismatch repair deficient (MMRd), high tumor mutational burden (TMB-H) , high homologous recombination deficiency (HRD), and tumor infiltrated immune cells (TILs) are known as effective biomarkers for immunotherapy, growing studies have reported that ICIs could not improve the OS of all patients with PD-L1 expression higher than 50%, and the ORR of MSI-H patients was only about 60%, whereas some patients with low PD-L1 expression or MSS could still benefit from immunotherapy, indicating the complexity of ICI resistance. Therefore, it is of great importance and significance to explore the prediction biomarkers for primary or acquired immunotherapy resistance and elucidate their underlying molecular mechanisms and develop reversal strategies. Due to the multiple steps of the cancer immune cycle and complex immune microenvironment, any disorders of immune cell infiltration or T cell activation, such as lack of antigens and/or their presentation, lack of response to antigen presentation, and T cell priming, could contribute to ICI resistance. The combination with anti-angiogenesis therapy, radiotherapy, chemotherapy, and other ICIs has improved the efficacy of ICI therapy to some extent in the clinic. Although numerous studies related to ICI resistance were reported in GI cancers, due to the strong spatial/temporal heterogeneity and the complex immune microenvironment in different kinds of GI cancers and different individuals, many questions about ICI resistance and reversal strategies remain unsolved. The aim of this Research Topic is to provide a forum to exhibit the latest research achievement related to the exploration of biomarkers for immunotherapy resistance including HPD and the underlying molecular mechanisms, as well as the development of reversal strategies in GI cancers. We hope this Research Topic will lead to a better understanding of precision cancer immunotherapy and provide useful clues for clinical application to benefit more GI cancer patients with immunotherapy.
Author: Ahmed Lasfar
Publisher: Frontiers Media SA
ISBN: 2889632830
Category :
Languages : en
Pages : 148
Get Book
Book Description
Author: Wei Zhao
Publisher: Frontiers Media SA
ISBN: 2889741842
Category : Science
Languages : en
Pages : 487
Get Book
Book Description
Author: Sameer Ullah Khan
Publisher: Springer Nature
ISBN: 9819716667
Category :
Languages : en
Pages : 392
Get Book
Book Description
Author: Peter P. Lee
Publisher: Springer Nature
ISBN: 303038862X
Category : Medical
Languages : en
Pages : 326
Get Book
Book Description
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Author: Cristina Maccalli
Publisher: Springer
ISBN: 3030166244
Category : Medical
Languages : en
Pages : 256
Get Book
Book Description
This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.
Author: Syed Mahmood
Publisher: Frontiers Media SA
ISBN: 2832548857
Category : Science
Languages : en
Pages : 173
Get Book
Book Description
The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has profoundly shifted the paradigms of molecular cancer research and drug discovery. The intricate networks of immune-inflammatory cells and signalling, cancer-associated fibroblasts, endothelial cells and adipose cells are extensively researched for diagnostics, therapeutics and predictive values. This includes siRNA and miRNA nanotherapeutics targeting these molecular components, owing to their powerful gene-silencing properties. Despite the concerted effort in the development of drug targeting TME, such as BLZ945 (a colony-stimulating factor-1 receptor inhibitor), there is a void in clinically satisfactory drug to target this intricate factor, thus far.
Author: Salem Chouaib
Publisher: Frontiers Media SA
ISBN: 2889638170
Category :
Languages : en
Pages : 196
Get Book
Book Description
Author: Noha Mousaad Elemam
Publisher: Frontiers Media SA
ISBN: 2832534929
Category : Medical
Languages : en
Pages : 144
Get Book
Book Description
One of the current challenges and failures of immunotherapy is in part due to the complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. The TME consists of various cell types (tumor cells, fibroblasts, endothelial cells, and immune cells), soluble signaling molecules (cytokines, growth factors, and chemokines), and extracellular matrix. On another note, metabolic disturbances in various TME components, such as hypoxia, acidosis, lactate accumulation, and nutrient deprivation, can play a critical role in the tumor progression. Furthermore, genetic and epigenetic dysfunctions are known to be part of the characteristics of cancer development. The immune cells could have a pro- or anti-tumor role in the TME, and their activity might vary in the context of different cancers. Both innate and adaptive immune cells interact with tumor cells through direct contact or through chemokines and cytokines signaling, shaping the tumor's activity and response to therapy.
