Transgenic and Knockout Models of Neuropsychiatric Disorders PDF Download
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Author: Gene S. Fisch
Publisher: Springer Science & Business Media
ISBN: 1597450588
Category : Medical
Languages : en
Pages : 295
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Book Description
In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.
Author: Gene S. Fisch
Publisher: Springer Science & Business Media
ISBN: 1597450588
Category : Medical
Languages : en
Pages : 295
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Book Description
In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.
Author: Jerry J. Buccafusco
Publisher: CRC Press
ISBN: 1420041819
Category : Medical
Languages : en
Pages : 341
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Book Description
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Author: Jacqueline N. Crawley
Publisher: John Wiley & Sons
ISBN: 0470119047
Category : Science
Languages : en
Pages : 544
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Book Description
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.
Author: Leonardo F. Fontenelle
Publisher: Cambridge University Press
ISBN: 1107195772
Category : Medical
Languages : en
Pages : 457
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Book Description
Using a transdiagnostic framework, this book describes how mental health professionals can diagnose and treat OCD and related disorder.
Author: Michael Koch
Publisher: World Scientific
ISBN: 1783260068
Category : Medical
Languages : en
Pages : 426
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Book Description
Animal models of neuro- and psychopathological states in humans are an indispensable part of both experimental neurology and biological psychiatry. Written by a team of experts, this book provides an up-to-date detailed overview of the current approaches to the design of viable animal models for eight prominent neuropsychiatric diseases. The book is specifically written with the research-oriented reader in mind — both in academia and the pharmaceutical industry. It contains first-hand information on how to design viable animal models for Alzheimer's disease, epilepsy, Huntington's disease, Parkinson's disease, addiction, depression, fear and anxiety, and schizophrenia. Each chapter also critically discusses the limitations of the animal experimental approach towards an understanding of human neuropsychiatric disorders.The book is an essential source of reference for researchers who seek to successfully continue and elaborate the experimental work that will finally lead to a better understanding of the neurobiological basis of the diseases, as well as to an improvement of both diagnosis and therapy.
Author: Helen Blair Simpson
Publisher: Cambridge University Press
ISBN: 1139490664
Category : Medical
Languages : en
Pages :
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Book Description
Anxiety disorders are amongst the most common of all mental health problems. Research in this field has exploded over recent years, yielding a wealth of new information in domains ranging from neurobiology to cultural anthropology to evidence-based treatment of specific disorders. This book offers a variety of perspectives on new developments and important controversies relevant to the theory, research, and clinical treatment of this class of disorders. Clinicians will find reviews of state-of-the-art treatments for panic disorder, social anxiety disorder, phobias, obsessive-compulsive disorder, generalized anxiety disorder, and post-traumatic stress disorder, as well as controversies over diagnostic and treatment issues. Researchers will find in-depth consideration of important selected topics, including genetics, neuroimaging, animal models, contemporary psychoanalytic theory, and the impact of stressors. This book illustrates the enormous advances that have occurred in anxiety research and describes the evolving multi-disciplinary efforts that will shape the future of the field.
Author: Shobha Malviya
Publisher:
ISBN: 9781468497175
Category :
Languages : en
Pages : 324
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Book Description
Author: Wim E. Crusio
Publisher: Cambridge University Press
ISBN: 1107355575
Category : Science
Languages : en
Pages : 361
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Book Description
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Author: Robert Thompson
Publisher: Springer Science & Business Media
ISBN: 1475795483
Category : Medical
Languages : en
Pages : 223
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Book Description
This book is the outcome of a decade of research on the neu roanatomical mechanisms of learning in the young laboratory rat. It is essentially a discourse on the functional organization of the brain in relation to problem-solving ability and intelli gence. During the period between 1980 and 1989, well over 1000 weanling albino rats were subjected to localized brain damage (or sham operations in the case of the controls) under deep anesthesia and aseptic surgical conditions, were allowed tore cover, and subsequently were tested on a wide variety of prob lems designed to measure general learning ability. Since vir tually every part of the brain rostral to the medulla has been explored with lesions, it has become possible not only to map a number of "putative" brain systems underlying the acquisition of distinctive problem-solving tasks, but to isolate several neu roanatomical mechanisms that appear to be selectively in volved in the acquisition of particular kinds of goal-directed learned activities. Of particular interest was the discovery of a "nonspecific mechanism" (previously referred to in our re search reports as the "general learning system") inhabiting the interior parts of the brain. One objective of this volume was to make these maps available in a single source. Another was to provide a descrip tion of learning syndromes arising from local lesions to differ ent parts of the brain.
Author: Akira Sawa
Publisher: Elsevier Science
ISBN: 9780444534309
Category : Medical
Languages : en
Pages : 144
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Book Description
This is a well-established international series that examines major areas of basic and clinical research within neuroscience (as well as emerging and promising subfields): neuroanatomy, neurophysiology, neuroimaging, neurobiology, neuropharmacology, neuroendocrinology, neuropathology, neuropsychiatry, and neurobehavior. This volume provides a thorough treatment of gene models of schizophrenia, presenting articles from leading contributors in this important area.
