Tracer Kinetics and Physiologic Modeling PDF Download
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Author: R.M. Lambrecht
Publisher: Springer Science & Business Media
ISBN: 3642500366
Category : Mathematics
Languages : en
Pages : 518
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Book Description
Author: R.M. Lambrecht
Publisher: Springer Science & Business Media
ISBN: 3642500366
Category : Mathematics
Languages : en
Pages : 518
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Book Description
Author: Eckart Frehland
Publisher:
ISBN:
Category : Biological transport
Languages : en
Pages : 509
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Book Description
Author: Claudio Cobelli
Publisher: Springer Science & Business Media
ISBN: 0306464276
Category : Mathematics
Languages : en
Pages : 455
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Book Description
The use of mathematical modeling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This includes not only understanding mechanisms of physiological processes, but also diagnosis and treatment. In addition, its introduction in the study of genomics and proteomics is key in understanding the functional characteristics of gene expression and protein assembly and secretion. Finally, with the increasing complexity and associated cost of drug development, modeling techniques are being used to streamline the process. This book is designed to give the reader the mathematical and statistical information necessary to design tracer kinetic studies, to use noncompartmental methodologies and/or to develop multicompartmental models to interpret the data. The book starts with a review of fundamentals of radioactive and stable isotope tracer kinetics and then proceeds with a description of the noncompartmental and multicompartmental modeling methodologies to study systems in the steady state. The focus is on understanding the basic assumptions inherent in the methodologies and the underlying mathematics and statistics, on discussing how to assess how `good' a model is and on giving some hints on how better to design kinetic studies, in order to increase the probability of a successful study and to ensure the maximal information content in the experimental data to be extracted. The book has an extensive section on parameter estimation, i.e., fitting models to data, first in general terms and then specifically related to noncompartmental and compartmental models. This is written from a basic point of view, and is intended to remove the mystery from the `black box' of computer optimization software. Finally, a special application often found in tracer kinetic analysis, precursor-product relationships, is discussed. Throughout the book, the goal is to provide even the novice with sufficient background so that he/she can feel comfortable. A number of case studies, based upon real experimental data, are carried through the text. Other examples illustrate specific points. All data examples are provided on a floppy disk.
Author: Ewart Carson
Publisher: Newnes
ISBN: 0124095259
Category : Technology & Engineering
Languages : en
Pages : 589
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Book Description
Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems
Author: Magdy M. Khalil
Publisher: Springer Nature
ISBN: 3030652459
Category : Medical
Languages : en
Pages : 571
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Book Description
This book provides comprehensive and detailed information on the scientific bases of nuclear medicine, addressing a wide variety of topics and explaining the concepts that underlie many of the investigations and procedures performed in the field. The book is divided into six sections that cover the physics and chemistry of nuclear medicine besides associated quality assurance/quality control procedures; dosimetry and radiation biology; SPECT and PET imaging instrumentation plus CT imaging technology in hybrid modalities; data analysis including image processing, reconstruction, radiomics, image degrading correction techniques, along with image quantitation and kinetic modeling. Within these sections, particular attention is paid to recent developments and the advances in knowledge that have taken place since release of the first edition in 2011. Several entirely new chapters have been included and the remaining chapters, thoroughly updated. Innovations in the ever-expanding field of nuclear medicine are predominantly due to integration of the basic sciences with complex technological advances. This excellently illustrated book on the subject will be of interest to not only nuclear medicine physicists and physicians but also clinical scientists, radiologists, radiopharmacists, medical students and technologists.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Our goal is to quantify regional physiological processes such as blood flow and metabolism by means of tracer kinetic modeling and positron emission tomography (PET). Compartmental models are one way of characterizing the behavior of tracers in physiological systems. This paper describes a general method of estimating compartmental model rate constants from measurements of the concentration of tracers in blood and tissue, taken at multiple time intervals. A computer program which applies the method is described, and examples are shown for simulated and actual data acquired from the Donner 280-Crystal Positron Tomograph.
Author: Ewart Carson
Publisher: Elsevier
ISBN: 0080511902
Category : Mathematics
Languages : en
Pages : 437
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Book Description
Modelling Methodology for Physiology and Medicine offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modelling methodology that is widely applicable to physiology and medicine. The book opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. Builds upon and enhances the readers existing knowledge of modelling methodology and practice Editors are internationally renowned leaders in their respective fields
Author: Michael Chappell
Publisher: Springer Nature
ISBN: 303039705X
Category : Technology & Engineering
Languages : en
Pages : 179
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Book Description
This book provides an introduction to qualitative and quantitative aspects of human physiology. It examines biological and physiological processes and phenomena, including a selection of mathematical models, showing how physiological problems can be mathematically formulated and studied. It also illustrates how a wide range of engineering and physics topics, such as electronics, fluid dynamics, solid mechanics and control theory can be used to describe and understand physiological processes and systems. Throughout the text, there are introductions to measuring and quantifying physiological processes using both signaling and imaging technologies. This new edition includes updated material on pathophysiology, metabolism and the TCA cycle, as well as more advanced worked examples. This book describes the basic structure and models of cellular systems, the structure and function of the cardiovascular system, and the electrical and mechanical activity of the heart, and provides an overview of the structure and function of the respiratory and nervous systems. It also includes an introduction to the basic concepts and applications of reaction kinetics, pharmacokinetic modelling and tracer kinetics. It appeals to final year biomedical engineering undergraduates and graduates alike, as well as to practising engineers new to the fields of bioengineering or medical physics.
Author: Tobias Schröder
Publisher:
ISBN: 9783940046468
Category :
Languages : en
Pages : 130
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Book Description
Author: Dale L. Bailey
Publisher: Springer Science & Business Media
ISBN: 1846280079
Category : Medical
Languages : en
Pages : 381
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Book Description
Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protection, and applications in dedicated areas such as drug development, oncology, and gene expression imaging. The technologist, the science, engineering or chemistry graduate seeking further detailed information about PET, or the medical advanced trainee wishing to gain insight into the basic science of PET will find this book invaluable. This book is primarily repackaged content from the Basic Science section of the 'big' Valk book on PET. It contains new, completely revised and unchanged chapters covering the "basic sciences" section of the main book - total 18 chapters: 2 new (chapters 1, 16) 8 completely revised (chapters 4, 5, 8, 13, 14, 15, 17, 18) 3 minor corrections (chapters 2, 6, 11) 5 unchanged (chapters 3, 7, 9, 10, 12)
