Toxicological Profile for Methylenedianiline PDF Download
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Author:
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ISBN:
Category : Aniline
Languages : en
Pages : 200
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Author:
Publisher:
ISBN:
Category : Aniline
Languages : en
Pages : 200
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Author:
Publisher:
ISBN:
Category : Aniline
Languages : en
Pages : 188
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Author: Gloria J. Hathaway
Publisher: John Wiley & Sons
ISBN: 9780471268833
Category : Medical
Languages : en
Pages : 808
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Book Description
The indispensable resource for health professionals on potentially unsafe chemicals--now fully updated Proctor and Hughes' Chemical Hazards of the Workplace, Fifth Edition provides a comprehensive reference text for health professionals who need toxicology data on chemicals that may be encountered in various work settings. Building on the success of the Fourth Edition-already a standard text-this new edition updates and revises the more than 600 entries of that text, and also adds monographs on new compounds. Introductory chapters cover toxicological concepts, clinical manifestations of exposure, the diagnosis of occupational disease, and industrial hygiene aspects of chemical exposures. The rest of the text consists of more than 625 alphabetically arranged entries on individual compounds, each of which includes: * Chemical formula * CAS number * 2003 ACGIH (American Conference of Government Industrial Hygienists) threshold limit value * Synonyms * Physical properties * Sources of exposure * Routes of exposure * Toxicological data The toxicological data includes both acute and chronic effects, especially as related to any known exposure levels. The data emphasizes human studies and cases over animal data whenever sufficient information is available, and addresses any known carcinogenic, mutagenic, fetotoxic, or other reproductive effects. Clinical information is presented in a succinct narrative form to aid in understanding. Easy to use, in-depth, and comprehensive, Proctor and Hughes' Chemical Hazards of the Workplace, Fifth Edition offers occupational health physicians, nurses, industrial hygienists, and other safety professionals an invaluable and up-to-date resource.
Author: Shayne C. Gad
Publisher: Springer Nature
ISBN: 3030352412
Category : Medical
Languages : en
Pages : 496
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Book Description
While the safety assessment (“biocompatibility”) of medical devices has been focused on issues of local tissue tolerance (irritation, sensitization, cytotoxicity) and selected quantal effects (genotoxicity and acute lethality) since first being regulated in the late 1950s, this has changed as devices assumed a much more important role in healthcare and became more complex in both composition and in their design and operation. Add to this that devices now frequently serve as delivery systems for drugs, and that drugs may be combined with devices to improve device performance, and the problems of ensuring patient safety with devices has become significantly more complex. A part of this, requirements for ensuring safety (once based on use of previously acceptable materials – largely polymers and metals) have come to requiring determining which chemical entities are potentially released from a device into patients (and how much is released). Then an appropriate and relevant (yet also conservative) risk assessment must be performed for each identified chemical structure. The challenges inherent in meeting the current requirements are multifold, and this text seeks to identify, understand, and solve all of them. • Identify and verify the most appropriate available data. • As in most cases such data is for a different route of exposure, transform it for use in assessing exposure by the route of interest. • As the duration (and rate) of exposure to moieties released from a device are most frequently different (longer) than what available data speaks to, transformation across tissue is required. • As innate and adaptive immune responses are a central part of device/patient interaction, assessing potential risks on this basis are required. • Incorporating assessments for special populations such as neonates. • Use of (Q)SAR (Quantitative Structure Activity Relationships) modeling in assessments. • Performance and presentation of integrative assessments covering all potential biologic risks. Appendices will contain summarized available biocompatibility data for commonly used device materials (polymers and metals) and safety assessments on the frequently seen moieties in extractions from devices.
Author:
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Category : Carcinogenicity testing
Languages : en
Pages : 368
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Author:
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ISBN:
Category : Methyl groups
Languages : en
Pages : 152
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Author: Nat. Toxicology Program (NTP) (NIH)
Publisher: DIANE Publishing
ISBN: 1437987362
Category : Health & Fitness
Languages : en
Pages : 507
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Book Description
The Report on Carcinogens (RoC) is a congressionally mandated, science-based, public health document that identifies and discusses agents, substances, mixtures, or exposure circumstances (hereinafter referred to as "substances") that may pose a hazard to human health by virtue of their carcinogenicity. For each listed substance, the report contains a substance profile which provides information on (1) the listing status, (2) cancer studies in humans and animals, (3) studies of genotoxicity (ability to damage genes) and biologic mechanisms, (4) the potential for human exposure to these substances, and (5) Federalregulations to limit exposures. Eight substances have been added to this 12th ed. of the report, which now includes 240 listings. The industrial chemical formaldehyde and a botanical known as aristolochic acids are listed as known human carcinogens. Six other substances captafol, cobalt-tungsten carbide (in powder or hard metal form), certain inhalable glass wool fibers, o-nitrotoluene, riddelliine, and styrene are added as substances that are reasonably anticipated to be human carcinogens. Figures. This is a print on demand report.
Author: United States. Agency for Toxic Substances and Disease Registry
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author:
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Category : Poisoning
Languages : en
Pages : 1480
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Author:
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ISBN:
Category : Benzidine dyes
Languages : en
Pages : 202
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Book Description
