Author: Scott S. Harried
Publisher:
ISBN:
Category :
Languages : en
Pages : 378
Book Description
A Total Synthesis of ( - )-discodermolide
Author: Scott S. Harried
Publisher:
ISBN:
Category :
Languages : en
Pages : 378
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 378
Book Description
The Total Synthesis of Discodermolide
Author: Jennie Beth Nerenberg
Publisher:
ISBN:
Category :
Languages : en
Pages : 400
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 400
Book Description
Studies Toward the Total Synthesis of Discodermolide
Author: Ge Yang
Publisher:
ISBN:
Category :
Languages : en
Pages : 354
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 354
Book Description
The Total Synthesis of (+)-discodermolide
Author: Gordon John Florence
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
An Improved Total Synthesis of (+)-discodermolide
Author: Isabelle Lyothier
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
I. Total Synthesis of (+)-miyakolide
Author: David Patrick Halstead
Publisher:
ISBN:
Category : Macrolide antibiotics
Languages : en
Pages : 398
Book Description
Publisher:
ISBN:
Category : Macrolide antibiotics
Languages : en
Pages : 398
Book Description
Synthetic Studies Towards Discodermolide and a Total Synthesis of Didehydrodiscodermolide
Author: David Louis Clark
Publisher:
ISBN:
Category :
Languages : en
Pages : 338
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 338
Book Description
The Total Synthesis of (-)-discodermolide
Author: Yuping Qiu
Publisher:
ISBN:
Category :
Languages : en
Pages : 350
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 350
Book Description
Total Synthesis of (+)-discodermolide
Author: Alexander Arefolov
Publisher:
ISBN:
Category :
Languages : en
Pages : 396
Book Description
Abstract: An enantioselective total synthesis of the marine natural product (+)-discodermolide has been accomplished utilizing a highly convergent and stereocontrolled strategy. The C1-C24 fragment was constructed via a palladium-mediated sp 2 -sp 3 cross-coupling reaction between the C1-C14 vinyl iodide and the C15-C24 alkyl iodide subunits. The C1-C14 subunit was obtained using an acetate aldol reaction to construct the C6-C7 bond and install the C7 stereocenter with high levels of 1,5- anti stereoinduction. The key C13-C14 trisubstituted (Z)-olefin was prepared applying a novel hydrozirconation-cross-coupling methodology. The C1-C6, C7-C14 and C15-C24 subunits were synthesized using chiral silane-based asymmetric C-C bond construction methodology to introduce eight out of thirteen molecule's stereogenic centers. This synthesis illustrates the application of chiral crotylsilane bond construction methodology for the enantioselective synthesis of natural products and offers complementary approach to the aldol-based methodology. A highly flexible and stereoselective protocol for the synthesis of functionalized (Z)- and (E)-trisubstituted alkenes has been developed. The key steps are hydrozirconation-iodination of (1-alkynyl)trimethylsilane followed by Negishi-type cross-coupling. The resultant (Z)-vinyl silane is iododesilylated and subjected to the second cross-coupling to give the trisubstituted olefin. Model studies aimed at the construction of C13-C14 trisubstituted olefin of (+)-discodermolide are described.
Publisher:
ISBN:
Category :
Languages : en
Pages : 396
Book Description
Abstract: An enantioselective total synthesis of the marine natural product (+)-discodermolide has been accomplished utilizing a highly convergent and stereocontrolled strategy. The C1-C24 fragment was constructed via a palladium-mediated sp 2 -sp 3 cross-coupling reaction between the C1-C14 vinyl iodide and the C15-C24 alkyl iodide subunits. The C1-C14 subunit was obtained using an acetate aldol reaction to construct the C6-C7 bond and install the C7 stereocenter with high levels of 1,5- anti stereoinduction. The key C13-C14 trisubstituted (Z)-olefin was prepared applying a novel hydrozirconation-cross-coupling methodology. The C1-C6, C7-C14 and C15-C24 subunits were synthesized using chiral silane-based asymmetric C-C bond construction methodology to introduce eight out of thirteen molecule's stereogenic centers. This synthesis illustrates the application of chiral crotylsilane bond construction methodology for the enantioselective synthesis of natural products and offers complementary approach to the aldol-based methodology. A highly flexible and stereoselective protocol for the synthesis of functionalized (Z)- and (E)-trisubstituted alkenes has been developed. The key steps are hydrozirconation-iodination of (1-alkynyl)trimethylsilane followed by Negishi-type cross-coupling. The resultant (Z)-vinyl silane is iododesilylated and subjected to the second cross-coupling to give the trisubstituted olefin. Model studies aimed at the construction of C13-C14 trisubstituted olefin of (+)-discodermolide are described.
Studies Towards the Total Synthesis of the Marine-derived Immunosuppressant Discodermolide
Author: Stephen P. Wren
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description