Author: Paul E. Holtzheimer
Publisher: Oxford University Press, USA
ISBN: 0199926484
Category : Medical
Languages : en
Pages : 194
Book Description
The Clinical Guide serves as a reference tool for clinicians in the administration of transcranial magnetic stimulation (TMS) for neuropsychiatric disorders. The primary intent of this Guide is to focus on the clinical applications of TMS and to offer detailed information on the safe and effective administration of TMS with consideration of the neurophysiological effects particularly in relation to safety, targeting specific cortical areas and practical issues such as the length of treatment sessions and the durability of the TMS response. The Guide focuses on the evidenced based literature and utilizes this literature to inform specific recommendations on the use of rTMS in a clinical setting. The efficacy and safety of TMS for neuropsychiatric disorders, including its use in special populations, such as the elderly, will be reviewed to facilitate clinical decision-making. The Guide will also outline setting up a TMS service including practical issues such as considerations for the qualifications of the person administering the treatment, the use of concomitant medications, what equipment is necessary to have in the treatment room and monitoring the outcomes to treatment. The Guide is intended to be a practical reference for the practicing clinician in the safe and effective administration of TMS.
A Clinical Guide to Transcranial Magnetic Stimulation
Author: Paul E. Holtzheimer
Publisher: Oxford University Press, USA
ISBN: 0199926484
Category : Medical
Languages : en
Pages : 194
Book Description
The Clinical Guide serves as a reference tool for clinicians in the administration of transcranial magnetic stimulation (TMS) for neuropsychiatric disorders. The primary intent of this Guide is to focus on the clinical applications of TMS and to offer detailed information on the safe and effective administration of TMS with consideration of the neurophysiological effects particularly in relation to safety, targeting specific cortical areas and practical issues such as the length of treatment sessions and the durability of the TMS response. The Guide focuses on the evidenced based literature and utilizes this literature to inform specific recommendations on the use of rTMS in a clinical setting. The efficacy and safety of TMS for neuropsychiatric disorders, including its use in special populations, such as the elderly, will be reviewed to facilitate clinical decision-making. The Guide will also outline setting up a TMS service including practical issues such as considerations for the qualifications of the person administering the treatment, the use of concomitant medications, what equipment is necessary to have in the treatment room and monitoring the outcomes to treatment. The Guide is intended to be a practical reference for the practicing clinician in the safe and effective administration of TMS.
Publisher: Oxford University Press, USA
ISBN: 0199926484
Category : Medical
Languages : en
Pages : 194
Book Description
The Clinical Guide serves as a reference tool for clinicians in the administration of transcranial magnetic stimulation (TMS) for neuropsychiatric disorders. The primary intent of this Guide is to focus on the clinical applications of TMS and to offer detailed information on the safe and effective administration of TMS with consideration of the neurophysiological effects particularly in relation to safety, targeting specific cortical areas and practical issues such as the length of treatment sessions and the durability of the TMS response. The Guide focuses on the evidenced based literature and utilizes this literature to inform specific recommendations on the use of rTMS in a clinical setting. The efficacy and safety of TMS for neuropsychiatric disorders, including its use in special populations, such as the elderly, will be reviewed to facilitate clinical decision-making. The Guide will also outline setting up a TMS service including practical issues such as considerations for the qualifications of the person administering the treatment, the use of concomitant medications, what equipment is necessary to have in the treatment room and monitoring the outcomes to treatment. The Guide is intended to be a practical reference for the practicing clinician in the safe and effective administration of TMS.
TMS 2014 143rd Annual Meeting & Exhibition, Annual Meeting Supplemental Proceedings
Author: The Minerals, Metals & Materials Society (TMS)
Publisher: Springer
ISBN: 3319482378
Category : Technology & Engineering
Languages : en
Pages : 1152
Book Description
These papers present advancements in all aspects of high temperature electrochemistry, from the fundamental to the empirical and from the theoretical to the applied. Topics involving the application of electrochemistry to the nuclear fuel cycle, chemical sensors, energy storage, materials synthesis, refractory metals and their alloys, and alkali and alkaline earth metals are included. Also included are papers that discuss various technical, economic, and environmental issues associated with plant operations and industrial practices.
Publisher: Springer
ISBN: 3319482378
Category : Technology & Engineering
Languages : en
Pages : 1152
Book Description
These papers present advancements in all aspects of high temperature electrochemistry, from the fundamental to the empirical and from the theoretical to the applied. Topics involving the application of electrochemistry to the nuclear fuel cycle, chemical sensors, energy storage, materials synthesis, refractory metals and their alloys, and alkali and alkaline earth metals are included. Also included are papers that discuss various technical, economic, and environmental issues associated with plant operations and industrial practices.
Dialysis
Author: Todd S. Ing
Publisher: World Scientific
ISBN: 9814289752
Category : Medical
Languages : en
Pages : 1008
Book Description
This book describes the past, present and future of dialysis and dialysis-related renal replacement therapies so that the reader can acquire a firm grasp of the medical management of acute and chronic renal failure. By becoming thoroughly conversant with the past and present of dialysis, a health care professional will be in a much better position to provide the best standard of care to patients suffering from renal failure. As the book highlights the unsolved operational obstacles in the field of renal replacement therapies, future innovators may be inspired to develop novel solutions to tackle these problems. This remarkable work is a must-read not just for health care providers in the dialysis industry, but for patients, dialysis equipment manufacturers as well as pharmaceutical companies.
Publisher: World Scientific
ISBN: 9814289752
Category : Medical
Languages : en
Pages : 1008
Book Description
This book describes the past, present and future of dialysis and dialysis-related renal replacement therapies so that the reader can acquire a firm grasp of the medical management of acute and chronic renal failure. By becoming thoroughly conversant with the past and present of dialysis, a health care professional will be in a much better position to provide the best standard of care to patients suffering from renal failure. As the book highlights the unsolved operational obstacles in the field of renal replacement therapies, future innovators may be inspired to develop novel solutions to tackle these problems. This remarkable work is a must-read not just for health care providers in the dialysis industry, but for patients, dialysis equipment manufacturers as well as pharmaceutical companies.
Robotized Transcranial Magnetic Stimulation
Author: Lars Richter
Publisher: Springer Science & Business Media
ISBN: 1461473608
Category : Computers
Languages : en
Pages : 186
Book Description
Robotized Transcranial Magnetic Stimulation describes the methods needed to develop a robotic system that is clinically applicable for the application of transcranial magnetic stimulation (TMS). Chapter 1 introduces the basic principles of TMS and discusses current developments towards robotized TMS. Part I (Chapters 2 and 3) systematically analyzes and clinically evaluates robotized TMS. More specifically, it presents the impact of head motion on the induced electric field. In Part II (Chapters 3 to 8), a new method for a robust robot/camera calibration, a sophisticated force-torque control with hand-assisted positioning, a novel FTA-sensor for system safety, and techniques for direct head tracking, are described and evaluated. Part III discusses these developments in the context of safety and clinical applicability of robotized TMS and presents future prospects of robotized TMS. Robotized Transcranial Magnetic Stimulation is intended for researchers as a guide for developing effective robotized TMS solutions. Professionals and practitioners may also find the book valuable.
Publisher: Springer Science & Business Media
ISBN: 1461473608
Category : Computers
Languages : en
Pages : 186
Book Description
Robotized Transcranial Magnetic Stimulation describes the methods needed to develop a robotic system that is clinically applicable for the application of transcranial magnetic stimulation (TMS). Chapter 1 introduces the basic principles of TMS and discusses current developments towards robotized TMS. Part I (Chapters 2 and 3) systematically analyzes and clinically evaluates robotized TMS. More specifically, it presents the impact of head motion on the induced electric field. In Part II (Chapters 3 to 8), a new method for a robust robot/camera calibration, a sophisticated force-torque control with hand-assisted positioning, a novel FTA-sensor for system safety, and techniques for direct head tracking, are described and evaluated. Part III discusses these developments in the context of safety and clinical applicability of robotized TMS and presents future prospects of robotized TMS. Robotized Transcranial Magnetic Stimulation is intended for researchers as a guide for developing effective robotized TMS solutions. Professionals and practitioners may also find the book valuable.
E-Waste Management
Author: Klaus Hieronymi
Publisher: Routledge
ISBN: 1136299122
Category : Technology & Engineering
Languages : en
Pages : 289
Book Description
The landscape of electronic waste, e-waste, management is changing dramatically. Besides a rapidly increasing world population, globalization is driving the demand for products, resulting in rising prices for many materials. Absolute scarcity looms for some special resources such as indium. Used electronic products and recyclable materials are increasingly crisscrossing the globe. This is creating both - opportunities and challenges for e-waste management. This focuses on the current and future trends, technologies and regulations for reusable and recyclable e-waste worldwide. It compares international e-waste management perspectives and regulations under a view that includes the environmental, social and economic aspects of the different linked systems. It overviews the current macro-economic trends from material demand to international policy to waste scavenging, examines particular materials and product streams in detail and explores the future for e-waste and its’ management considering technology progress, improving end-of-lifecycle designs, policy and sustainability perspectives. To achieve this, the volume has been divided in twelve chapters that cover three major themes: holistic view of the global e-waste situation current reserve supply chain and management of used electronics, including flows, solutions, policies and regulations future perspectives and solutions for a sustainable e-waste management. The emphasis of the book is mainly on the dramatic change of the entire e-waste sector from the cheapest way of getting rid of e-waste in an environmental sound way to how e-waste can help to reduce excavation of new substances and lead to a sustainable economy. It is an ideal resource for policy-makers, waste managers and researchers involved in the design and implementation of e-waste.
Publisher: Routledge
ISBN: 1136299122
Category : Technology & Engineering
Languages : en
Pages : 289
Book Description
The landscape of electronic waste, e-waste, management is changing dramatically. Besides a rapidly increasing world population, globalization is driving the demand for products, resulting in rising prices for many materials. Absolute scarcity looms for some special resources such as indium. Used electronic products and recyclable materials are increasingly crisscrossing the globe. This is creating both - opportunities and challenges for e-waste management. This focuses on the current and future trends, technologies and regulations for reusable and recyclable e-waste worldwide. It compares international e-waste management perspectives and regulations under a view that includes the environmental, social and economic aspects of the different linked systems. It overviews the current macro-economic trends from material demand to international policy to waste scavenging, examines particular materials and product streams in detail and explores the future for e-waste and its’ management considering technology progress, improving end-of-lifecycle designs, policy and sustainability perspectives. To achieve this, the volume has been divided in twelve chapters that cover three major themes: holistic view of the global e-waste situation current reserve supply chain and management of used electronics, including flows, solutions, policies and regulations future perspectives and solutions for a sustainable e-waste management. The emphasis of the book is mainly on the dramatic change of the entire e-waste sector from the cheapest way of getting rid of e-waste in an environmental sound way to how e-waste can help to reduce excavation of new substances and lead to a sustainable economy. It is an ideal resource for policy-makers, waste managers and researchers involved in the design and implementation of e-waste.
Brain Stimulation
Author: Juha Silvanto
Publisher: Elsevier Inc. Chapters
ISBN: 0128080582
Category : Medical
Languages : en
Pages : 35
Book Description
The challenge in visual neuroscience is to characterize the neuronal properties and functional significance of the numerous regions of the visual cortex, and to understand how they interact during the processing of visual information. The strength of transcranial magnetic stimulation (TMS) in this endeavor is its ability to assess the necessity of visual cortical areas in perceptual functions and to trace the corticocortical interactions that underlie them. Most of the early studies in this field were carried out using the so-called “virtual lesion” approach, in which the impact of TMS was thought to be akin to inducing a brain lesion in the stimulated area. This approach established causal links between specific visual areas and perceptual functions such as motion perception, object processing, and visual awareness. Recently, the view of TMS as a tool for inducing “virtual lesion” has been challenged by a number of experimental findings, giving rise to the conceptualization of TMS effects as a state-dependent interaction between the initial state of the stimulated area and the parameters of the TMS pulse. This state dependency is the basis of paradigms aiming selectively to target specific neuronal representations and thus reveal neuronal tuning properties, a major challenge in the understanding of the cortical visual system.
Publisher: Elsevier Inc. Chapters
ISBN: 0128080582
Category : Medical
Languages : en
Pages : 35
Book Description
The challenge in visual neuroscience is to characterize the neuronal properties and functional significance of the numerous regions of the visual cortex, and to understand how they interact during the processing of visual information. The strength of transcranial magnetic stimulation (TMS) in this endeavor is its ability to assess the necessity of visual cortical areas in perceptual functions and to trace the corticocortical interactions that underlie them. Most of the early studies in this field were carried out using the so-called “virtual lesion” approach, in which the impact of TMS was thought to be akin to inducing a brain lesion in the stimulated area. This approach established causal links between specific visual areas and perceptual functions such as motion perception, object processing, and visual awareness. Recently, the view of TMS as a tool for inducing “virtual lesion” has been challenged by a number of experimental findings, giving rise to the conceptualization of TMS effects as a state-dependent interaction between the initial state of the stimulated area and the parameters of the TMS pulse. This state dependency is the basis of paradigms aiming selectively to target specific neuronal representations and thus reveal neuronal tuning properties, a major challenge in the understanding of the cortical visual system.
Clinical Neurophysiology: Basis and Technical Aspects
Author:
Publisher: Elsevier
ISBN: 0444640339
Category : Medical
Languages : en
Pages : 624
Book Description
Clinical Neurophysiology: Basis and Technical Aspects, the latest release in the Handbook of Clinical Neurology series, is organized into sections on basic physiological concepts, on the function and limitations of modern instrumentation, and on other fundamental or methodologic aspects related to the recording of various bioelectric signals from the nervous system for clinical or investigative purposes. There is discussion of the EEG, nerve conduction studies, needle electromyography, intra-operative clinical neurophysiology, sleep physiology and studies, the autonomic nervous system, various sensory evoked potentials, and cognitive neurophysiology. - Provides an up-to-date review on the practice of neurophysiological techniques in the assessment of neurological disease - Explores the electrophysiological techniques used to better understand neurological function and dysfunction, first in the area of consciousness and epilepsy, then in the areas of the peripheral nervous system and sleep - Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, magnetoencephalography, laser evoked potentials, and transcranial magnetic stimulation
Publisher: Elsevier
ISBN: 0444640339
Category : Medical
Languages : en
Pages : 624
Book Description
Clinical Neurophysiology: Basis and Technical Aspects, the latest release in the Handbook of Clinical Neurology series, is organized into sections on basic physiological concepts, on the function and limitations of modern instrumentation, and on other fundamental or methodologic aspects related to the recording of various bioelectric signals from the nervous system for clinical or investigative purposes. There is discussion of the EEG, nerve conduction studies, needle electromyography, intra-operative clinical neurophysiology, sleep physiology and studies, the autonomic nervous system, various sensory evoked potentials, and cognitive neurophysiology. - Provides an up-to-date review on the practice of neurophysiological techniques in the assessment of neurological disease - Explores the electrophysiological techniques used to better understand neurological function and dysfunction, first in the area of consciousness and epilepsy, then in the areas of the peripheral nervous system and sleep - Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, magnetoencephalography, laser evoked potentials, and transcranial magnetic stimulation
Textbook of Neural Repair and Rehabilitation
Author: Michael E. Selzer
Publisher: Cambridge University Press
ISBN: 1107011671
Category : Nervous system
Languages : en
Pages : 693
Book Description
In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.
Publisher: Cambridge University Press
ISBN: 1107011671
Category : Nervous system
Languages : en
Pages : 693
Book Description
In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.
At the doors of lexical access: The importance of the first 250 milliseconds in reading
Author: Jon Andoni Dunabeitia
Publisher: Frontiers E-books
ISBN: 2889192601
Category : Psychology
Languages : en
Pages : 113
Book Description
Correct word identification and processing is a prerequisite for accurate reading, and decades of psycholinguistic and neuroscientific research have shown that the magical moments of visual word recognition are short-lived and markedly fast. The time window in which a given letter string passes from being a mere sequence of printed curves and strokes to acquiring the word status takes around one third of a second. In a few hundred milliseconds, a skilled reader recognizes an isolated word and carries out a number of underlying processes, such as the encoding of letter position and letter identity, and lexico-semantic information retrieval. However, the precise manner (and order) in which these processes occur (or co-occur) is a matter of contention subject to empirical research. There’s no agreement regarding the precise timing of some of the essential processes that guide visual word processing, such as precise letter identification, letter position assignment or sub-word unit processing (bigrams, trigrams, syllables, morphemes), among others. Which is the sequence of processes that lead to lexical access? How do these and other processes interact with each other during the early moments of word processing? Do these processes occur in a serial fashion or do they take place in parallel? Are these processes subject to mutual interaction principles? Is feedback allowed for within the earliest stages of word identification? And ultimately, when does the reader’s brain effectively identify a given word? A vast number of questions remain open, and this Research Topic will cover some of them, giving the readership the opportunity to understand how the scientific community faces the problem of modeling the early stages of word identification according to the latest neuroscientific findings. The present Research Topic aimed to combine recent experimental evidence on early word processing from different techniques together with comprehensive reviews of the current work directions, in order to create a landmark forum in which experts in the field defined the state of the art and future directions. We were willing to receive submissions of empirical as well as theoretical and review articles based on different computational and neuroscience-oriented methodologies. We especially encouraged researchers primarily using electrophysiological or magnetoencephalographic techniques as well as eye-tracking to participate, given that these techniques provide us with the opportunity to uncover the mysteries of lexical access allowing for a fine-grained time-course analysis. The main focus of interest concerned the processes that are held within the initial 250-300 milliseconds after word presentation, covering areas that link basic visuo-attentional systems with linguistic mechanisms.
Publisher: Frontiers E-books
ISBN: 2889192601
Category : Psychology
Languages : en
Pages : 113
Book Description
Correct word identification and processing is a prerequisite for accurate reading, and decades of psycholinguistic and neuroscientific research have shown that the magical moments of visual word recognition are short-lived and markedly fast. The time window in which a given letter string passes from being a mere sequence of printed curves and strokes to acquiring the word status takes around one third of a second. In a few hundred milliseconds, a skilled reader recognizes an isolated word and carries out a number of underlying processes, such as the encoding of letter position and letter identity, and lexico-semantic information retrieval. However, the precise manner (and order) in which these processes occur (or co-occur) is a matter of contention subject to empirical research. There’s no agreement regarding the precise timing of some of the essential processes that guide visual word processing, such as precise letter identification, letter position assignment or sub-word unit processing (bigrams, trigrams, syllables, morphemes), among others. Which is the sequence of processes that lead to lexical access? How do these and other processes interact with each other during the early moments of word processing? Do these processes occur in a serial fashion or do they take place in parallel? Are these processes subject to mutual interaction principles? Is feedback allowed for within the earliest stages of word identification? And ultimately, when does the reader’s brain effectively identify a given word? A vast number of questions remain open, and this Research Topic will cover some of them, giving the readership the opportunity to understand how the scientific community faces the problem of modeling the early stages of word identification according to the latest neuroscientific findings. The present Research Topic aimed to combine recent experimental evidence on early word processing from different techniques together with comprehensive reviews of the current work directions, in order to create a landmark forum in which experts in the field defined the state of the art and future directions. We were willing to receive submissions of empirical as well as theoretical and review articles based on different computational and neuroscience-oriented methodologies. We especially encouraged researchers primarily using electrophysiological or magnetoencephalographic techniques as well as eye-tracking to participate, given that these techniques provide us with the opportunity to uncover the mysteries of lexical access allowing for a fine-grained time-course analysis. The main focus of interest concerned the processes that are held within the initial 250-300 milliseconds after word presentation, covering areas that link basic visuo-attentional systems with linguistic mechanisms.
Manipulative approaches to human brain dynamics
Author: Keiichi Kitajo
Publisher: Frontiers Media SA
ISBN: 2889194795
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 247
Book Description
In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
Publisher: Frontiers Media SA
ISBN: 2889194795
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 247
Book Description
In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.