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Author: A. Douglas Kinghorn
Publisher: Springer Nature
ISBN: 3031671805
Category :
Languages : en
Pages : 197
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Book Description
Author: A. Douglas Kinghorn
Publisher: Springer Nature
ISBN: 3031671805
Category :
Languages : en
Pages : 197
Get Book Here
Book Description
Author: Bin Yu
Publisher: Elsevier
ISBN: 044318612X
Category : Medical
Languages : en
Pages : 988
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Book Description
Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. - Provides wide coverage of privileged scaffolds in new drug discovery - Includes complex and diverse natural product scaffolds - Covers applications to peptides and peptide-based drugs
Author: A. Douglas Kinghorn
Publisher: Springer
ISBN: 3319331728
Category : Science
Languages : en
Pages : 258
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Book Description
The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.
Author: Seyed Mohammad Nabavi
Publisher: Elsevier
ISBN: 0128164557
Category : Science
Languages : en
Pages : 878
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Book Description
Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included.
Author: Namrita Lall
Publisher: Academic Press
ISBN: 0128168218
Category : Medical
Languages : en
Pages : 360
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Book Description
Underexplored Medicinal Plants from Sub-Saharan Africa: Plants with Therapeutic Potential for Human Health examines a comprehensive selection of rarely explored plants that have been underestimated for their therapeutic value. The book contains monographs of medicinal plants, outlining their botanical description, geographical distribution, ethnobotanical usage, chemical constituents, sample and standard preparations and methods, and pharmacological properties. With expert contributors from South Africa, Mauritius, Seychelles, Cameroon and Nigeria, and the compilation of ethnobotanical, taxonomic and pharmacologic information for each species, this book is a valuable resource for researchers, academics in pharmacology, ethnopharmacology, medicinal plant sciences, and more. - Explores the therapeutic potential of a comprehensive selection of underexplored and underutilized medicinal plants in sub-Sahara Africa - Provides a summary table of structures of any known natural products, including details of plant source (chapter) and observed activity (e.g. anticancer, antibacterial) - Includes contributions from experts from South African, Mauritius, Seychelles, Cameroon and Nigeria
Author: Lemmens, R.H.M.J., Louppe, D. & Oteng-Amoako, A.A.
Publisher: PROTA
ISBN: 9290814950
Category : Timber
Languages : en
Pages : 804
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Book Description
Author: Barry M. Trost
Publisher: Elsevier
ISBN: 0080912524
Category : Science
Languages : en
Pages : 828
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Book Description
Cumulative Indexes
Author: Anil Kumar Saxena
Publisher: Springer
ISBN: 3319782541
Category : Science
Languages : en
Pages : 258
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Book Description
This book reviews the current strategies and challenges for the treatment of bacterial, fungal, parasitic and viral infectious diseases in developing countries. Contributing authors present expert analysis on the transmission, epidemiology, bacteriology, pathogenesis and treatment of Neglected Tropical Bacterial Diseases such as Leprosy, Buruli ulcer, and Trachoma. Particular attention is also given to current antifungal agents, their spectrum of activity, mode of action, limitations, and current challenges in antifungal therapy. The authors explore the medicinal chemistry efforts that gave rise to currently launched drugs and new anti-HIV agents, and they also highlight the latest vaccine and drug developments in the clinical management of the Ebola Virus Disease, ignited by the 2014-2016 outbreak. This work has an interdisciplinary appeal and will engage scholars and professionals in the burden of communicable diseases.
Author: Jun Yang
Publisher: OAE Publishing Inc.
ISBN:
Category : Science
Languages : en
Pages : 54
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Book Description
Chiral spirolactones, including spiropropyllactones, spirobutyrolactones, and spirovalerolactones, are important heterocyclic frameworks that attracted the attention of organic and medicinal chemists because these motifs constitute the core structure of several natural products and bioactive molecules. The absolute configuration and the substituents on the fully substituted spirocyclic stereocenter of the lactone can potentially enhance specificity for ligand-protein binding and enhance bioavailability, potency, and metabolic stability. So, intensive attention from chemists has been paid to the synthetic methods leading to such prominent structural motifs. The synthetic methods can be divided into two main classes. The first approach takes advantage of the presence of the existing lactone structure and focuses on its functionalization. The second approach is the lactone framework constructed from various precursors in a direct spirolactonization reaction. In this review, for convenience in reading, the recent advances in the synthesis of spirolactones are summarized and discussed according to the two major organocatalytic asymmetric synthetic routes: (i) using the lactone-related frameworks as building blocks; and (ii) direct spirolactonization reaction using various reagents. This review also describes both the mechanisms and related transformations, and gives some insights into challenging issues in this research field, which will enlighten the future development of this field.
Author: Rakesh Kumar Sharma
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110797461
Category : Science
Languages : en
Pages : 606
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Book Description
Carbon-carbon and carbon-heteroatom bond-forming reactions are the backbone of synthetic organic chemistry. Scientists are constantly developing and improving these techniques in order to maximize the diversity of synthetically available molecules. These techniques must be developed in a sustainable manner in order to limit their environmental impact. This book highlights green bond forming reactions for bioactive scaffolds.
