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Author: Werner Hacke
Publisher: Springer Science & Business Media
ISBN: 3642764398
Category : Medical
Languages : en
Pages : 355
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Book Description
During the last decade scientists in both basic and clinical research have renew ed their interest in the potential role of thrombolytic therapy in the treatment of acute ischemic stroke. The reevaluation of this approach was kindled by our growing knowledge of the pathogenesis of thrombotic and embolic stroke and by the development of new thrombolytic agents. With no proven therapy for acute ischemic stroke available, the potential value of early pharmacologic recanalization of occluded vessels in the management of acute stroke patients - an approach that has been supported by animal experiments and a limited number of uncontrolled clinical pilot studies - is again under scrutiny. A sym posium on "Thrombolysis in Acute Cerebral Ischemia" was held in Heidel berg, Germany, in May 1990 to summarize and discuss the pathophysiological background for thrombolysis in acute ischemic stroke and the recent ex perimental and clinical experience with the new generation of thrombolytic agents. The editors are fortunate to be able to include authoritative manuscripts from almost all the speakers at the symposium. These include reports of work by the most active investigators in this challenging field. The editors wish to express their gratitude to all the contributors for the additional work they have undertaken. Additionally, we would like to thank Springer-Verlag, Heidelberg, for its generous assistance in the preparation and rapid publication of this volume. Heidelberg, August 1990 WERNER HACKE GREGORY J. DEL ZopPO MATTHIAS HIRSCHBERG Contents I.
Author: Werner Hacke
Publisher: Springer Science & Business Media
ISBN: 3642764398
Category : Medical
Languages : en
Pages : 355
Get Book
Book Description
During the last decade scientists in both basic and clinical research have renew ed their interest in the potential role of thrombolytic therapy in the treatment of acute ischemic stroke. The reevaluation of this approach was kindled by our growing knowledge of the pathogenesis of thrombotic and embolic stroke and by the development of new thrombolytic agents. With no proven therapy for acute ischemic stroke available, the potential value of early pharmacologic recanalization of occluded vessels in the management of acute stroke patients - an approach that has been supported by animal experiments and a limited number of uncontrolled clinical pilot studies - is again under scrutiny. A sym posium on "Thrombolysis in Acute Cerebral Ischemia" was held in Heidel berg, Germany, in May 1990 to summarize and discuss the pathophysiological background for thrombolysis in acute ischemic stroke and the recent ex perimental and clinical experience with the new generation of thrombolytic agents. The editors are fortunate to be able to include authoritative manuscripts from almost all the speakers at the symposium. These include reports of work by the most active investigators in this challenging field. The editors wish to express their gratitude to all the contributors for the additional work they have undertaken. Additionally, we would like to thank Springer-Verlag, Heidelberg, for its generous assistance in the preparation and rapid publication of this volume. Heidelberg, August 1990 WERNER HACKE GREGORY J. DEL ZopPO MATTHIAS HIRSCHBERG Contents I.
Author: Patrick D. Lyden
Publisher: Springer Science & Business Media
ISBN: 1592599338
Category : Medical
Languages : en
Pages : 392
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Book Description
It often takes time for a new therapeutic modality to mature into an accepted treatment option. After initial approval, new drugs, devices, and procedures all go through this process until they become “vetted” by the scientific community as well as the medical community at large. Thrombolysis for treatment of stroke is no exception. Thrombolytic Therapy for Acute Stroke, Second Edition comes four years after the first edition and provides a very comprehensive, updated perspective on the use of intravenous rt-TPA in acute stroke. The authors provide longer term follow-up on the pivotal clinical trials that led to Food and Drug Administration approval, data concerning phase 4 trials in larger numbers of patients, and, most importantly, the community experience that has accumulated since its release. They add to this the latest promising information concerning intra-arterial thrombolysis, which is still under investigation and more speculative sections concerning possible new avenues of clinical research such as combining intravenous thr- bolysis with neuroprotective therapies or intra-arterial thrombolysis. A wealth of factual information is supplemented by chapters containing sage opinion from Drs. Lyden and Caplan concerning the logistical, economic, and procedural issues that have been generated since the advent of this technology. Importantly, diagnosis does not take a back seat to therapeutics as illustrated by sections devoted to eva- ation of the stroke patient, very useful illustrative cases and clinical comments, and chapters on the latest in imaging as applied to this field.
Author: Werner Hacke
Publisher: Springer
ISBN: 9783540536802
Category : Medical
Languages : en
Pages : 271
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Book Description
During the last decade scientists in both basic and clinical research have renew ed their interest in the potential role of thrombolytic therapy in the treatment of acute ischemic stroke. The reevaluation of this approach was kindled by our growing knowledge of the pathogenesis of thrombotic and embolic stroke and by the development of new thrombolytic agents. With no proven therapy for acute ischemic stroke available, the potential value of early pharmacologic recanalization of occluded vessels in the management of acute stroke patients - an approach that has been supported by animal experiments and a limited number of uncontrolled clinical pilot studies - is again under scrutiny. A sym posium on "Thrombolysis in Acute Cerebral Ischemia" was held in Heidel berg, Germany, in May 1990 to summarize and discuss the pathophysiological background for thrombolysis in acute ischemic stroke and the recent ex perimental and clinical experience with the new generation of thrombolytic agents. The editors are fortunate to be able to include authoritative manuscripts from almost all the speakers at the symposium. These include reports of work by the most active investigators in this challenging field. The editors wish to express their gratitude to all the contributors for the additional work they have undertaken. Additionally, we would like to thank Springer-Verlag, Heidelberg, for its generous assistance in the preparation and rapid publication of this volume. Heidelberg, August 1990 WERNER HACKE GREGORY J. DEL ZopPO MATTHIAS HIRSCHBERG Contents I.
Author: Gregory J. DelZoppo
Publisher: Springer Science & Business Media
ISBN: 364278061X
Category : Medical
Languages : en
Pages : 485
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Book Description
Over the last decade, interest in treatment of ischemic stroke has increased significantly. Perhaps the single most important feature of attempts to improve the outcome of stroke patients has been that the interventions be applied within the very early hours of stroke symptoms. This has spawned efforts to understand the vascular and neuronal responses to cerebral artery reperfusion experimentally. Important prospective clinical studies of thrombolysis in acute ischemic stroke have been completed, and large placebo-controlled, symptom-based studies are now underway worldwide. Here, we consider the central features of those studies, their experimental basis, and the future importance of adjunctive therapies to recanalization in focal brain ischemia acutely. Risks and benefits are discussed. This collection benefits from the opinions of experts and workers in this rapidly evolving and exciting field.
Author: R. Gilberto González
Publisher: Springer Science & Business Media
ISBN: 3642127517
Category : Medical
Languages : en
Pages : 299
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Book Description
This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.
Author: Patrick D. Lyden
Publisher: Springer Science & Business Media
ISBN: 1592591310
Category : Medical
Languages : en
Pages : 398
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Book Description
Thrombolytic Therapy for Stroke is intended for physicians who will be treating patients in the first few hours after stroke: neurologists, neurosurgeons, emergency medicine physicians, internists, and radiologists. In some areas, fam ily medicine general practice physicians may provide the majority of acute stroke care. We will provide the reader with all the data necessary to understand the utility and limitations of thrombolytic therapy. By reading the protocols, and working through the case tutorials, the reader will become sufficiently familiar with the indications and contraindications of thrombolytic therapy to begin evalu ating potential patients. Although nothing can replace direct instruction by more experienced physicians, we hope that by imparting our accumulated knowledge we may guide those physicians who cannot attend a "hands-on" workshop, or who, having heard the appropriate lectures, feel the need for further guidance. We will review the scientific rationale for thrombolysis: first, most ischemic stroke is caused by thrombo-emboli; second, a portion of brain, the penumbra, remains salvageable for a few hours after vascular occlusion; and third, promptly delivered thrombolysis can remove the offending occlusion and restore cerebral blood flow to the penumbra in time to salvage brain and neurologic function. Then we will review the preclinical development of thrombolytics for stroke pa tients and the early pilot trials. Next, we will present the pivotal clinical trials that demonstrated the efficacy and safety of thrombolysis.
Author: Takenori Yamaguchi
Publisher: Springer Science & Business Media
ISBN: 443168459X
Category : Medical
Languages : en
Pages : 358
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Book Description
On the threshold of an exciting new era for acute stroke diagnosis and treatment, the Third International Symposium on Thrombolytic Therapy in Acute Ischemic Stroke was held in Nara, Japan, in April 1994. The symposium brought together some 200 basic and clinical scientists for presentations and discussions of issues vital to the understanding of thrombolytic therapy. This volume compiles the major presentations of the symposium, with attention to applications of new diagnostic measures such as diffusion and perfusion MRI, contrast-enhanced transcranial Doppler and angioscopy. Other presentations examine the mechanisms of ischemia/reperfusion injury, hemorrhagic transformation, and reocclusion, with reviews of recent developments in thrombolytic agents. The proceedings of the symposium will be of special interest to researchers, physicians, and students in the fields of neurology, neurosurgery, and nuclear medicine, as well as those in pharmacology, critical care medicine, and related fields.
Author: Judith Mackay
Publisher: World Health Organization
ISBN: 9789241562768
Category : Medical
Languages : en
Pages : 118
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Book Description
Heart disease and strokes are currently the leading cause of death in all developed countries and in most developing countries, resulting in one third of all deaths globally in 2003. This publication explores a range of issues relating to this increasingly urgent global health problem using text, colour charts, maps and graphics. Topics covered include: different types of cardiovascular diseases, including rheumatic heart disease; key risk factors including smoking, obesity, physical inactivity, high cholesterol levels and diabetes; risks factors relating to women, childhood and youth; the global burden of coronary heart disease and stroke, and associated economic costs; medical research and funding issues; prevention in personal and public health terms; treatment options; health education; national policies and legislation to address prevention and control; future predictions; chronology of key developments in knowledge of cardiovascular disease; and world data tables.
Author: Jaime C. Paz
Publisher: Elsevier Health Sciences
ISBN: 0323227538
Category : Medical
Languages : en
Pages : 528
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Book Description
Familiarize yourself with the acute care environment with this essential guide to physical therapy practice in an acute care setting. Acute Care Handbook for Physical Therapists, 4th Edition helps you understand and interpret hospital protocol, safety, medical-surgical ‘lingo’, and the many aspects of patient are from the emergency department to the intensive care unit to the general ward. This restructured new edition streamlines the text into four parts— Introduction, Systems, Diagnoses, and Interventions to make the book even easier to use as a quick reference. Intervention algorithms, updated illustrations, and language consistent with the ICF model all help you digest new information and become familiar with new terminology. This comprehensive resource is just what you need to better manage the specific needs of your patients in the complex acute care environment. Intervention algorithms, tables, boxes, and clinical tips highlight key information about the acute care environment in a format that makes finding and digesting information easy. The major body system chapters provide the evidence-based information you need to understand the complex issues of patients in the acute care environment so you can optimally manage the needs of your patients. Current information on medications, laboratory tests, diagnostics, and intervention methods relevant to patients in the acute care environment illustrates how the acute care environment can impact these elements. Clinical tips highlight key points and provide access to the tips and tricks accumulated over a career by an experienced clinician. Language consistent with the Guide to Physical Therapist Practice, 2nd Edition offers common linguistic ground through the use of Guide standards. Lay-flat pages and uncluttered design make the book easier to use as a quick reference. NEW! Restructured table of contents helps you quickly locate information. NEW! Language from the International Classification of Functioning, Disability, and Health (ICF) model adopted by the American Physical Therapy Association increases your familiarity with terminology. NEW! New intervention algorithms along with existing algorithms break clinical decision-making into individual steps and sharpens your on-the-spot critical-thinking skills. NEW! A quick-reference appendix covering abbreviations commonly found in the acute care environment supplies the translation tools you need, while flagging any abbreviations that may be harmful to the patient.
Author: Sujoy Ghosh
Publisher: Elsevier Health Sciences
ISBN: 1455742112
Category : Medical
Languages : en
Pages : 343
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Book Description
The incidence of diabetes is increasing at epidemic proportions worldwide, presenting a huge challenge to modern medicine. In response, scientific advances in the understanding of diabetes and its complications are being translated into improved clinical practice at ever faster rates. Greater understanding of aetiopathogenesis of the different types of diabetes, the emerging roles of novel pharmacological agents and the importance placed on multidisciplinary team working and multi-risk-factor treatment all contribute to this. Now in a fully revised second edition, this clear, concise guide to modern diabetes and its management will prove invaluable to all health professionals in this field. Suitable for instant reference in the clinic or office. Helps answer the questions which diabetic patients will direct at their carers about their disease, its causes, prognosis and consequences for their lifestyle. Offers practical and accessible advice on all aspects of the condition from presentation and diagnosis to organisation of care. Suitable for diabetic nurses as well as junior doctors. Evidence based boxes give the rationale behind treatment decisions. Colour illustrations of important conditions such as diabetic retinopathy and foot disease. Key points highlighted throughout the book, vital/high risk points emphasized with exclamation mark icon. More information on insulin therapy, dyslipidaemia, macrovascular disease and hypertension. Complete rewrite of oral antidiabetic agents section. Smaller, more pocketable page size.
