Thermo-mechanical Behavior of Pharmaceutical Powders During Compaction Processes PDF Download
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Author: Sagar Laxmiprasad Uniyal
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Dry granulation / roller compaction is an enlargement process by agglomeration of the primary powders without adding any solvent. This operation makes it possible to homogenize the properties of pharmaceutical formulations and improve the flow properties necessary for the manufacture of tablets using rotary presses. In this process, temperature variations in the product are rarely considered. However, recent studies have shown that for pharmaceutical powders, such variations can lead to changes in mechanical and physico-chemical properties. In this thesis, a new method based on in-line measurements of powders temperature compacted by a roller press is developed using an infrared camera. Temperature distributions on the surface of the compact were determined using infrared radiation emitted by the compact after leaving the gap. These distributions showed a correlation with the microstructural properties of the compact, confirming the potential of this procedure in monitoring product quality. To understand the potential sources of the heating of pharmaceutical products in dry granulation, a heat balance model was established in anticipation of the numerical simulation of the thermomechanical coupling of the process by finite element method. As the thermal properties of the compact depend on the relative density, the thermal conductivity and the specific heat were characterized for two model pharmaceutical excipients. In addition, the impact of dry granulation on the rearrangement and densification of granules in die compression is studied using a mathematical model (Cooper-Eaton) which allowed to a better understanding of the contribution of dry granulation to tableting process.
Author: Sagar Laxmiprasad Uniyal
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Dry granulation / roller compaction is an enlargement process by agglomeration of the primary powders without adding any solvent. This operation makes it possible to homogenize the properties of pharmaceutical formulations and improve the flow properties necessary for the manufacture of tablets using rotary presses. In this process, temperature variations in the product are rarely considered. However, recent studies have shown that for pharmaceutical powders, such variations can lead to changes in mechanical and physico-chemical properties. In this thesis, a new method based on in-line measurements of powders temperature compacted by a roller press is developed using an infrared camera. Temperature distributions on the surface of the compact were determined using infrared radiation emitted by the compact after leaving the gap. These distributions showed a correlation with the microstructural properties of the compact, confirming the potential of this procedure in monitoring product quality. To understand the potential sources of the heating of pharmaceutical products in dry granulation, a heat balance model was established in anticipation of the numerical simulation of the thermomechanical coupling of the process by finite element method. As the thermal properties of the compact depend on the relative density, the thermal conductivity and the specific heat were characterized for two model pharmaceutical excipients. In addition, the impact of dry granulation on the rearrangement and densification of granules in die compression is studied using a mathematical model (Cooper-Eaton) which allowed to a better understanding of the contribution of dry granulation to tableting process.
Author: A. K. Aidah Jumahat
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Saurabh M. Mishra
Publisher:
ISBN:
Category :
Languages : en
Pages : 426
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Book Description
Pharmaceutical product development has evolved from conventional empirical approach towards the more systematic and science based approach over the past decades. However, the process of tableting and compaction behavior of pharmaceutical powders is still ambiguous and not well understood. In the present study, a comprehensive attempt has been made to understand this complex and dynamic process of compaction of disordered pharmaceutical powders using percolation phenomenon. Commonly used pharmaceutical powder materials, spheres and their binary mixtures of different particle sizes, crystal structure and deformation behavior were compressed at varying compression loads at different relative densities. Mechanical strength of tablets, namely radial tensile strength, compressive strength and elastic modulus, were evaluated and studied according to the classical models of powder compaction and percolation phenomenon. It was found that percolation phenomenon has a significant effect on the compaction of powder materials and can be used to characterize deformation and bonding behavior of powder materials. A model developed on the fundamentals of percolation theory was found to predict the compactibility of disordered powder materials and their binary mixtures with higher accuracy compared to the established classical compaction models. Moreover, it was found that the developed model can predict the dilution capacity of excipients and can be used as a material-sparing tool in the initial formulation development of tablet dosage forms. It was also found that percolation theory can help to understand mechanics of tablet formation more clearly by establishing a relationship between compressibility and compactibility phenomena of powder materials. Further, a closer look at tableting process reveals that process of tableting closely mimics 3-dimensional correlated diffusive percolation phenomenon with a universal critical exponent value of q = 2 and percolation thresholds, Ï1c = 0.634 (z = 12) and 0.366 (z = 6) depending on the type of material used. Similar results were also observed in the case of powders compacted using an industrial scale rotary tablet press thus confirming that tableting of pharmaceutical powders is far from an equilibrium process depending upon the variability of time and space. Thus it can be concluded that comprehensive application of percolation theory can serve as a single effective tool in the study of compaction behavior of pharmaceutical powders and can be effectively used in the current quality by design (QbD) practice to establish robust design space for the formulation development of tablet dosage forms.
Author: Metin Çelik
Publisher: CRC Press
ISBN: 1420089188
Category : Medical
Languages : en
Pages : 360
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Book Description
Compaction of powder constituents-both active ingredient and excipients-is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists,
Author: Kevin M.G. Taylor
Publisher: Elsevier Health Sciences
ISBN: 0702053937
Category : Medical
Languages : en
Pages : 909
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Book Description
Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient. Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art. New to this edition New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. Twenty-two new contributors. Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. Thoroughly revised and updated throughout. provides a logical, comprehensive account of drug design and manufacture includes the science of formulation and drug delivery designed and written for newcomers to the design of dosage forms New to this edition New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. Twenty-two new contributors. Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. Thoroughly revised and updated throughout.
Author: Fridrun Podczeck
Publisher: World Scientific
ISBN: 1783262311
Category : Medical
Languages : en
Pages : 254
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Book Description
This monograph describes the physical principles of adhesion between particles and surfaces. These principles are applied to pharmaceutical processes involved in the manufacture of solid dosage forms such as powders, granules, tablets and dry powder inhalations. To help in the understanding of these systems, physical properties of solid surfaces, and an introduction to the theory of friction is given. Techniques for measuring particle adhesion and fracture mechanical properties of powders are introduced, as far as these are relevant to the processes discussed. The philosophy of the book deviates from that of standard pharmaceutical textbooks, in that it focuses primarily on physical principles involved in the manufacture of dosage forms rather than describing these processes purely by observation.
Author: Kevin M.G. Taylor
Publisher: Elsevier Health Sciences
ISBN: 0702081566
Category : Medical
Languages : en
Pages : 1052
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Book Description
The essential pharmaceutics textbook One of the world’s best-known texts on pharmaceutics, Aulton's Pharmaceutics offers a complete course in one book for students in all years of undergraduate pharmacy and pharmaceutical sciences degrees. Thoroughly revised, updated and extended by experts in their fields and edited by Professors Kevin Taylor and Michael Aulton, this new edition includes the science of formulation, pharmaceutical manufacturing and drug delivery. All aspects of pharmaceutics are covered in a clear and readily accessible way and extensively illustrated throughout, providing an essential companion to the entire pharmaceutics curriculum from day one until the end of the course. Fully updated throughout, with the addition of new chapters, to reflect advances in formulation and drug delivery science, pharmaceutical manufacturing and medicines regulation Designed and written for newcomers to the design and manufacture of dosage forms Relevant pharmaceutical science covered throughout Includes the science of formulation and drug delivery Reflects current practices and future applications of formulation and drug delivery science to small drug molecules, biotechnology products and nanomedicines Key points boxes throughout Over 400 online multiple choice questions
Author: Dilip M. Parikh
Publisher: CRC Press
ISBN: 1616310030
Category : Medical
Languages : en
Pages : 678
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Book Description
The Third Edition presents all pharmaceutical industry personnel and those in academia with critical updates on the recent advances in granulation technology and changes in FDA regulatory guidelines. Addressing precisely how these recent innovations and revisions affect unit operation of particle generation and granulation, this text assists the re
Author: Gweni Alonso Aruffo
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
The production of compacts with complex geometries by means of powder die compaction can be a delicate task. The compression process, used in many industrial sectors, is based on the densification of a powder bed by the application of an external load to obtain compacts. In some situations, the presence of defects (for example, cracks) in the compacts can be observed following the compression process. These lead to the degradation of the mechanical properties of the compacts and therefore their properties of use, thus leading to the non-conformity of the sample. Defects in powder compacts can be mainly due to the homogeneity of the compact, the mechanical behaviour of the powder and the complexity of the geometric shape of the sample. The work of this thesis contributes to the analysis of the compaction of pharmaceutical powders on large compacts with complex geometry (presence of grooves). In particular, to further understand the impact of the geometry of the compression tools on the final state of the compacts, both experimental and numerical studies were carried out. In order to model the mechanical response of the powder in compression to an external load, the Drucker Prager Cap (DPC) model was employed. To overcome a scaling problem, a hybrid calibration method of the DPC model was introduced in this work to provide a more realistic prediction of the powder behaviour in compression. The numerical results obtained by finite element simulation were validated by means of tomographic analysis.
Author:
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Category :
Languages : en
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