The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease PDF Download
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Author: Concetta Bubici
Publisher: Frontiers Media SA
ISBN: 2889630013
Category :
Languages : en
Pages : 128
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Book Description
Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.
Author: Concetta Bubici
Publisher: Frontiers Media SA
ISBN: 2889630013
Category :
Languages : en
Pages : 128
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Book Description
Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.
Author: Marina Belozerskaya
Publisher: Getty Publications
ISBN: 0892367857
Category : Art
Languages : en
Pages : 292
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Book Description
Today we associate the Renaissance with painting, sculpture, and architecture—the “major” arts. Yet contemporaries often held the “minor” arts—gem-studded goldwork, richly embellished armor, splendid tapestries and embroideries, music, and ephemeral multi-media spectacles—in much higher esteem. Isabella d’Este, Marchesa of Mantua, was typical of the Italian nobility: she bequeathed to her children precious stone vases mounted in gold, engraved gems, ivories, and antique bronzes and marbles; her favorite ladies-in-waiting, by contrast, received mere paintings. Renaissance patrons and observers extolled finely wrought luxury artifacts for their exquisite craftsmanship and the symbolic capital of their components; paintings and sculptures in modest materials, although discussed by some literati, were of lesser consequence. This book endeavors to return to the mainstream material long marginalized as a result of historical and ideological biases of the intervening centuries. The author analyzes how luxury arts went from being lofty markers of ascendancy and discernment in the Renaissance to being dismissed as “decorative” or “minor” arts—extravagant trinkets of the rich unworthy of the status of Art. Then, by re-examining the objects themselves and their uses in their day, she shows how sumptuous creations constructed the world and taste of Renaissance women and men.
Author: Boaventura de Sousa Santos
Publisher: Routledge
ISBN: 1317260341
Category : Political Science
Languages : en
Pages : 285
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Book Description
This book explores the concept of 'cognitive injustice': the failure to recognise the different ways of knowing by which people across the globe run their lives and provide meaning to their existence. Boaventura de Sousa Santos shows why global social justice is not possible without global cognitive justice. Santos argues that Western domination has profoundly marginalised knowledge and wisdom that had been in existence in the global South. She contends that today it is imperative to recover and valorize the epistemological diversity of the world. Epistemologies of the South outlines a new kind of bottom-up cosmopolitanism, in which conviviality, solidarity and life triumph against the logic of market-ridden greed and individualism.
Author: Aby Warburg
Publisher: Getty Publications
ISBN: 9780892365371
Category : Art, Renaissance
Languages : en
Pages : 872
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Book Description
A collection of essays by the art historian Aby Warburg, these essays look beyond iconography to more psychological aspects of artistic creation: the conditions under which art was practised; its social and cultural contexts; and its conceivable historical meaning.
Author: Keith Block
Publisher: Bantam
ISBN: 0553801147
Category : Health & Fitness
Languages : en
Pages : 610
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Book Description
Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for.
Author: Tobias M. Scholz
Publisher: Peter Lang Gmbh, Internationaler Verlag Der Wissenschaften
ISBN: 9783631718902
Category : Business & Economics
Languages : en
Pages : 237
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Book Description
Big data are changing the way we work. This book conveys a theoretical understanding of big data and the related interactions on a socio-technological level as well as on the organizational level. Big data challenge the human resource department to take a new role. An organization's new competitive advantage is its employees augmented by big data.
Author: William David Davies
Publisher: Cambridge University Press
ISBN: 9780521219297
Category : Religion
Languages : en
Pages : 766
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Book Description
Vol. 4 covers the late Roman period to the rise of Islam. Focuses especially on the growth and development of rabbinic Judaism and of the major classical rabbinic sources such as the Mishnah, Jerusalem Talmud, Babylonian Talmud and various Midrashic collections.
Author: Michael H. Crutcher
Publisher:
ISBN:
Category : National security
Languages : en
Pages : 412
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Book Description
This is an anthology of papers presented at a conference titled "Russian National Security: Perceptions, Policies, and Prospects" conducted from 4-6 December 2000. The book organizes the papers into six sections - The Russian National Security Community, Russia and Europe, Russian Policy Towards the Caucasus and Central Asia, Russia and Asia, Russia and the United States, and Russia's Military Transformation.
Author: P. Kennedy
Publisher: Springer
ISBN: 0333985451
Category : Social Science
Languages : en
Pages : 268
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Book Description
Drawing on original research from social scientists working on twelve countries this book explores the key issues faced by nations and citizens as they struggle to rediscover, reaffirm or reconstruct their sense of national identities in the face of globalizing forces. Some nations and peoples experience the fragmentation of once certain identities as threatening and likely to generate political and social breakdown. Others encounter globalization as a challenge which brings uncertainties but also opportunities for adaptation, the evolution of hybrid identities or new forms of protest.
Author: W. Krohn
Publisher: Springer Science & Business Media
ISBN: 9401729751
Category : Social Science
Languages : en
Pages : 278
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Book Description
may be complex without being able to be replaced by something »still more simple«. This became evident with the help of computer models of deterministic-recursive systems in which simple mathematical equation systems provide an extremely complex behavior. (2) Irregularity of nature is not treated as an anomaly but becomes the focus of research and thus is declared to be normal. One looks for regularity within irregularity. Non-equilibrium processes are recognized as the source of order and the search for equilibrium is replaced by the search for the dynamics of processes. (3) The classical system-environment model, according to which the adaptation of a system to its environment is controlled externally and according to which the adaptation of the system occurs in the course of a learning process, is replaced by a model of systemic closure. This closure is operational in so far as the effects produced by the system are the causes for the maintenance of systemic organization. If there is sufficient complexity, the systems perform internal self-observation and exert self-control (»Cognition« as understood by Maturana as self-perception and self-limitation, e. g. , that of a cell vis-a. -vis its environment). 22 But any information a system provides on its environment is a system-internal construct. The »reference to the other« is merely a special case of »self-reference«. The social sciences frequently have suffered from the careless way in which scientific ideas and models have been transferred.
