The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease PDF Download
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Author: Concetta Bubici
Publisher: Frontiers Media SA
ISBN: 2889630013
Category :
Languages : en
Pages : 128
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Book Description
Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.
Author: Concetta Bubici
Publisher: Frontiers Media SA
ISBN: 2889630013
Category :
Languages : en
Pages : 128
Get Book Here
Book Description
Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.
Author: Boaventura de Sousa Santos
Publisher: Routledge
ISBN: 1317260341
Category : Political Science
Languages : en
Pages : 285
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Book Description
This book explores the concept of 'cognitive injustice': the failure to recognise the different ways of knowing by which people across the globe run their lives and provide meaning to their existence. Boaventura de Sousa Santos shows why global social justice is not possible without global cognitive justice. Santos argues that Western domination has profoundly marginalised knowledge and wisdom that had been in existence in the global South. She contends that today it is imperative to recover and valorize the epistemological diversity of the world. Epistemologies of the South outlines a new kind of bottom-up cosmopolitanism, in which conviviality, solidarity and life triumph against the logic of market-ridden greed and individualism.
Author: Ali Madanipour
Publisher: Routledge
ISBN: 1134519850
Category : Architecture
Languages : en
Pages : 276
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Book Description
The relationship between public and private spheres is one of the key concerns of the modern society. This book investigates this relationship, especially as manifested in the urban space with its social and psychological significance. Through theoretical and historical examination, it explores how and why the space of human socities is subdivided into public and private sections. It starts with the private, interior space of the mind and moves step by step, through the body, home, neighborhood and the city, outwards to the most public, impersonal spaces, exploring the nature of each realm and their complex, interdependent realtionships. A stimulating and thought provoking book for any architect, architectural historian, urban planner or designer.
Author: James Cowan
Publisher: Cambridge Scholars Publishing
ISBN: 144388149X
Category : City planning
Languages : en
Pages : 273
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Book Description
Occasionally a man emerges from history without us knowing him. Duke Vespasiano Gonzaga (1531–91) of Sabbioneta escaped the net of sixteenth century Italy, its history of wars and conflicts, to fashion a life that was uniquely different. He set out to change the way urban man lived. Importantly, he was the first man to build a Città ideale. Sabbioneta is the prototype of all planned cities of the modern era. As a confidant of King Philip II of Spain and a traveller, he quickly acquired a cosmopolitan worldview, which led him to become a uomo universale. It was in this capacity that he designed Sabbioneta as a genuine “little Athens.” His life was fraught with tragedy, however. Not only did he suffer from syphilis, but his personal troubles left him emotionally damaged. The mysterious death of two wives, including the beautiful Diana of Cardona, forced him to find solace in the construction of his ideal city. As nephew to the legendary Giulia Gonzaga – and with her encouragement – the Duke managed to forge a career as a poet, bibliophile, antiquarian, condottiero, urban planner and diplomat, all against the backdrop of New World discovery, the Protestant Reformation, and the Inquisition. This book reveals another fascinating story: Vespasiano Gonzaga’s link to Shakespeare’s Hamlet. Like the Prince of Denmark, he reflects the emergence of our modern consciousness. He was a true Renaissance man whose legacy remains with us to this day. As a self-fashioned personality, the Duke made every attempt to place himself at the forefront of events of his time. His life tells us a great deal about how late-Renaissance men exteriorised their inner world in a bid to achieve immortality.
Author: Sofia Zoitou
Publisher: Mediterranean Art Histories
ISBN: 9789004436855
Category : History
Languages : en
Pages : 284
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Book Description
"In Staging Holiness. The Case of Hospitaller Rhodes (ca. 1309-1522) Sofia Zoitou offers a study of the history of relic collections, devotional rituals and sites invested with special meaning in Rhodes, during a time when the island became one of the most frequented ports of call for ships carrying pilgrims from Venice to the Holy Land. Scrutinizing late medieval travel reports by pilgrims from all over Europe along with extant historical, archaeological, visual and material evidence, Sofia Zoitou traces the various forms of the Rhodian cultic sites' evolution and perception, ultimately considered as an overall artistic strategy for the staging of the sacred"--
Author: Anne Le
Publisher: Springer
ISBN: 331977736X
Category : Medical
Languages : en
Pages : 186
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Book Description
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author: Jerry H. Bentley
Publisher: Cambridge University Press
ISBN: 9780521761628
Category : History
Languages : en
Pages : 0
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Book Description
The era from 1400 to 1800 saw intense biological, commercial, and cultural exchanges, and the creation of global connections on an unprecedented scale. Divided into two books, Volume 6 of the Cambridge World History series considers these critical transformations. The first book examines the material and political foundations of the era, including global considerations of the environment, disease, technology, and cities, along with regional studies of empires in the eastern and western hemispheres, crossroads areas such as the Indian Ocean, Central Asia, and the Caribbean, and sites of competition and conflict, including Southeast Asia, Africa, and the Mediterranean. The second book focuses on patterns of change, examining the expansion of Christianity and Islam, migrations, warfare, and other topics on a global scale, and offering insightful detailed analyses of the Columbian exchange, slavery, silver, trade, entrepreneurs, Asian religions, legal encounters, plantation economies, early industrialism, and the writing of history.
Author: Chris Beasley
Publisher: SAGE
ISBN: 9780761969792
Category : Psychology
Languages : en
Pages : 312
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Book Description
About various theories of gender, sexuality, feminism and masculinity including queer theory, transgender theorizing, modernist liberationism and social constructionism.
Author: Janine Natalya Clark
Publisher: Cambridge University Press
ISBN: 110891151X
Category : Law
Languages : en
Pages : 309
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Book Description
Processes of post-war reconstruction, peacebuilding and reconciliation are partly about fostering stability and adaptive capacity across different social systems. Nevertheless, these processes have seldom been expressly discussed within a resilience framework. Similarly, although the goals of transitional justice – among them (re)establishing the rule of law, delivering justice and aiding reconciliation – implicitly encompass a resilience element, transitional justice has not been explicitly theorised as a process for building resilience in communities and societies that have suffered large-scale violence and human rights violations. The chapters in this unique volume theoretically and empirically explore the concept of resilience in diverse societies that have experienced mass violence and human rights abuses. They analyse the extent to which transitional justice processes have – and can – contribute to resilience and how, in so doing, they can foster adaptive peacebuilding. This book is available as Open Access.
Author: Erik Grimmer-Solem
Publisher: Cambridge University Press
ISBN: 1108483828
Category : History
Languages : en
Pages : 669
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Book Description
The First World War marked the end point of a process of German globalization that began in the 1870s. Learning Empire looks at German worldwide entanglements to recast how we interpret German imperialism, the origins of the First World War, and the rise of Nazism.
