Author: Marlies Elger
Publisher: Springer Science & Business Media
ISBN: 3642804497
Category : Medical
Languages : en
Pages : 137
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Book Description
Glomerular flltration represents one of the basic mechanisms in the function of an organism. Our understanding of this process is still quite fragmentary. Regulation of blood flow and pressure, together with regulation of the ultraflltration coefficient (which is an attribute of the flltration barrier), are the two fundamental mechanisms accounting for maintenance and adaptability of glomerular flltration. Regulation of glomerular blood flow is generally considered to result from an interplay between afferent and efferent glomerular arterioles, and much progress has been made recently in understanding this interplay (Navar et al. 1996). The present study provides a detailed structural description of the glomerular vascular pole of rat. The results of this study appear to be relevant for several open questions of glomerular function. First, the interaction between afferent and efferent arterioles in regulating glomerular blood is generally understood to occur between the preglomerular and the postglomerular portions of these vessels. As shown in the present study, the structural elaborations of these arterioles and the spatial relationships between them within the glomerular hilum strongly suggest an interplay also at this site. Moreover, the current understanding of glomerular blood flow regulation by tuning the interplay between afferent and efferent arterioles is exclusively based on signals whose regulatory loops are established in follow-up events outside the glomerulus (tubuloglomerular balance, tubuloglomerular feedback).
Author: Marlies Elger
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 116
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Book Description
Knowledge of the architecture of the renal glomerulus is a prerequisite for understanding both glomerular function and pathology. Glomerular filtration depends on comparably high intracapillary hydrostatic pressures. These high pressures must be balanced by commensurate counterforces to maintain structural integrity. Elevated pressures can damage the glomerulus. The "window" for pressures high enough for effective filtration and yet tolerable to the glomerulus is narrow. Precise regulation is therefore necessary to keep intraglomerular pressure within an appropriate range. This study provides a comprehensive description of the glomerular arterioles, which are the vessels primarily responsible for the regulation of intraglomerular pressures. It thereby describes the structures which may be presumed to generate counterforces needed to assure structural stability. The arterioles are closely associated with the supporting system comprised of the intra- and extraglomerular mesangium. The extraglomerular mesangium forms a spider-like clamp providing a mechanical interconnection of all components of the vascular pole. At the same time, it may act as a tension receptor, i.e. as a sensor of intraglomerular pressures. Due to its intimate relationship to the macula densa, the extraglomerular mesangium receives information on the distal solute delivery and therefore may act as the integrative center within the juxtaglomerular apparatus. The close spatial association between the afferent and efferent arterioles at the vascular pole suggests a direct regulatory interaction between both arterioles. In addition, the specific wall structure of the efferent arteriole exhibiting the features of a shear stress receptor suggests new pathways for feedback regulation of glomerular hemodynamics.
Author: Marlies Elger
Publisher:
ISBN: 9783642804502
Category :
Languages : en
Pages : 112
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Book Description
Author: Xin J. Zhou
Publisher: Cambridge University Press
ISBN: 1316613984
Category : Medical
Languages : en
Pages : 691
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Book Description
An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.
Author: Andrew W. Suttie
Publisher: Academic Press
ISBN: 0123914892
Category : Medical
Languages : en
Pages : 750
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Book Description
Boorman's Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. - Contains full, four color photographs from the NTP archive and database and coverage of all rat strains - Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes - Includes comprehensive and detailed background incidence data - Presents detailed descriptive content regarding changes in rat models during research
Author: Ellis D. Avner
Publisher: Springer Science & Business Media
ISBN: 3540763279
Category : Medical
Languages : en
Pages : 2059
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Book Description
Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.
Author: Rachel K. Miller
Publisher: Springer
ISBN: 3319514369
Category : Science
Languages : en
Pages : 373
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Book Description
Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.
Author: Jerry B. Hook
Publisher: CRC Press
ISBN: 9780881678857
Category : Medical
Languages : en
Pages : 588
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Book Description
This second edition provides a synthesis of recent research on the mechanisms of chemically-induced kidney injury. The text includes a review of current concepts of clinical nephrotoxicity and renal failure, and mechanisms of specific classes of nephrotoxic drugs and environmental chemicals.
Author: Christopher J. Lote
Publisher: Springer Science & Business Media
ISBN: 9780792361787
Category : Medical
Languages : en
Pages : 222
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Book Description
The strengths of this popular text { its conciseness and logical progr ession through renal physiology and pathophysiology { are retained in the 4th edition. The text has been updated throughout, and the content has been expanded to make the book eminently suitable for 'systems-ba sed' courses.
Author: Robert J. Alpern
Publisher: Elsevier
ISBN: 0080559506
Category : Science
Languages : en
Pages : 2922
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Book Description
A classic nephrology reference for over 20 years, Seldin & Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch's The Kidney is your number one source for information.* Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner & Rector's The Kidney which devotes only 7 chapters to this topic.* Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner & Rector's only devotes 5 chapters to these topics.* Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition. * Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.
