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Author: Willis X. Li
Publisher: Springer Nature
ISBN: 3031290291
Category : Science
Languages : en
Pages : 62
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Book Description
This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
Author: Willis X. Li
Publisher: Springer Nature
ISBN: 3031290291
Category : Science
Languages : en
Pages : 62
Get Book Here
Book Description
This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
Author: Lewis Wolpert
Publisher: W. W. Norton & Company
ISBN: 039329272X
Category : Science
Languages : en
Pages : 169
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Book Description
Acclaimed biologist Lewis Wolpert eloquently narrates the basics of human life through the lens of its smallest component: the cell. Everything about our existence— imagination and reproduction, birth and death—is governed by our cells. They are the basis of all life in the universe, from the tiniest of bacteria to the most complex of animals. Genes in developing embryos determine the makeup of individuals, and the rapid firing between nerve cells creates the spirit of who we are. When we age, our cells cannot repair the damage they have undergone; when we get ill, it is because cells are so damaged they stop working and die. In the tradition of Lewis Thomas’s science classic The Lives of a Cell, Wolpert, an internationally acclaimed embryologist, draws on the recent discoveries of genetics to demonstrate how human life derives from a single cell and then grows into a body: an incredibly complex society made up of billions of cells. Wolpert sensitively examines the science behind often controversial research topics that are much discussed by rarely understood—stem cell research, cloning, DNA, and mutating cancer cells—all the while illuminating how the intricacies of cellular behavior bear directly on human behavior. Wolpert isn’t afraid to tackle the tough questions, including how and why single cells evolved into complex organisms and, first and foremost, what gave rise to the original cell, the origin of all life. Lively and passionate, How We Live and Why We Die is both an accessible guide to understanding the human body and a deeply reverent meditation on life itself.
Author: Vishal Madan
Publisher: BoD – Books on Demand
ISBN: 9535103091
Category : Medical
Languages : en
Pages : 138
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Book Description
Basal cell carcinoma is the commonest cutaneous malignancy. The last decade has witnessed exponential research which has broadened our understanding of the pathogenesis of basal cell carcinomas. This is also important from a therapeutic point of view as targeted approach to therapy is now being increasingly experimented. Although it is impossible to condense and present all good research in one book, the authors have to be commended on presenting their research on several aspects of basal cell carcinoma in a succinct manner, which shall not only enhance our understanding of, but also hopefully via this open exchange of ideas pave ways for successful targeted therapy of the commonest human cancer.
Author: Kate Atkinson
Publisher: Random House
ISBN: 1409043762
Category : Fiction
Languages : en
Pages : 341
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Book Description
The magnificent novel by bestselling and award-winning Kate Atkinson: 'A masterpiece' - Telegraph; 'Pageturner' - Evening Standard; 'Wise, funny and paced like a thriller' Observer In 1940, eighteen-year old Juliet Armstrong is reluctantly recruited into the world of espionage. Sent to an obscure department of MI5 tasked with monitoring the comings and goings of British Fascist sympathizers, she discovers the work to be by turns both tedious and terrifying. But after the war has ended, she presumes the events of those years have been relegated to the past for ever. Ten years later, now a producer at the BBC, Juliet is unexpectedly confronted by figures from her past. A different war is being fought now, on a different battleground, but Juliet finds herself once more under threat. A bill of reckoning is due, and she finally begins to realize that there is no action without consequence. Transcription is a work of rare depth and texture, a bravura modern novel of extraordinary power, wit and empathy. It is a triumphant work of fiction from one of this country’s most exceptional writers. 'How vehemently most novelists will wish to produce a masterpiece as good' Telegraph ______________
Author: Paul Pumpens
Publisher: CRC Press
ISBN: 042967290X
Category : Science
Languages : en
Pages : 835
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Book Description
This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies
Author: Matthew Cobb
Publisher: Basic Books
ISBN: 0465062660
Category : Science
Languages : en
Pages : 384
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Book Description
Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life's secrets. Life's Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life's) future. Life's Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters -- mathematicians, physicists, information theorists, and biologists -- who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or "junk DNA" was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb's telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who'd like to explore those questions for themselves.
Author: William B. Miller
Publisher: CRC Press
ISBN: 1000909182
Category : Science
Languages : en
Pages : 329
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Book Description
Cognition-Based Evolution is the first comprehensive alternative to 20th-century Neodarwinism, proposing a radical 21st-century evolutionary framework with a novel point of origination: all cells are intelligent and must measure uncertain environmental information to sustain themselves. In Cognition-Based Evolution, life is defined by cognition. From this differential stance, evolutionary biology transforms into the science of why, how, what, and with whom cells measure and communicate under stressful environmental conditions. Life's context is uncertain environmental information, communication is its means, and genes are its tools. Evolution is its yield as continuous non-random self-referential cellular problem-solving.
Author: Jiwei Zhang
Publisher: Frontiers Media SA
ISBN: 2832515045
Category : Science
Languages : en
Pages : 152
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1940
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author: Thomas A. Fleisher
Publisher: Elsevier Health Sciences
ISBN: 0723436916
Category : Medical
Languages : en
Pages : 1325
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Book Description
Written and edited by international leaders in the field, this book has, through two best-selling editions, been the place to turn for authoritative answers to your toughest challenges in clinical immunology. Now in full color and one single volume, the 3rd Edition brings you the very latest immunology knowledge - so you can offer your patients the best possible care. The user-friendly book and the fully searchable companion web site give you two ways to find the answers you need quickly...and regular online updates keep you absolutely current. Leading international experts equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. A highly clinical focus and an extremely practical organization expedite access to the answers you need in your daily practice. Cutting-edge coverage of the human genome project, immune-modifier drugs, and many other vital updates keeps you at the forefront of your field. A new organization places scientific and clinical material side by side, to simplify your research and highlight the clinical relevance of the topics covered. A multimedia format allows you to find information conveniently, both inside the exceptionally user-friendly book and at the fully searchable companion web site. Regular updates online ensure that you'll always have the latest knowledge at your fingertips. Includes many new and improved illustrations and four color design. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
