The Role of the Low Density Lipoprotein Receptor-related Protein (LRP) and Heparan Sulfate Proteoglycans (HSPGS) in Very Low Density Lipoprotein (VLDL) Metabolism PDF Download
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Author: Larissa C. Wilsie
Publisher:
ISBN:
Category : Lipids
Languages : en
Pages : 136
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Book Description
Author: Larissa C. Wilsie
Publisher:
ISBN:
Category : Lipids
Languages : en
Pages : 136
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Book Description
Author: A.D. Roses
Publisher: Springer Science & Business Media
ISBN: 3642801099
Category : Medical
Languages : en
Pages : 208
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Book Description
There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.
Author: Shallee Tyler Page
Publisher:
ISBN:
Category :
Languages : en
Pages : 412
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Book Description
Author: Gary D. Lopaschuk
Publisher: Springer
ISBN: 1493912275
Category : Science
Languages : en
Pages : 301
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Book Description
The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
Author: Jayme Borensztajn
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 352
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Book Description
Abstract: This text consists of reviews on lipoprotein lipase, which are limited to the detailed examination of only certain aspects of the enzyme. This text is intended to serve as a major source of reference to investigators interested in the enzyme and its function in normal and pathological conditions. Aspects of the enzyme considered in this discussion are: measurement of activity; role during lactation and in metabolic adaptation to exercise and training; lipoprotein lipase in adipose tissue, heart and skeleton muscle and from milk; activity in hypertriglyceridemias, diabetes, trauma and sepsis; comparative biochemistry and physiology.
Author: Meagan Roan Harris
Publisher:
ISBN:
Category :
Languages : en
Pages : 116
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Book Description
Author: Johnny Eugene Croy
Publisher:
ISBN:
Category :
Languages : en
Pages : 390
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Book Description
Author: Jen-Chywan Wang
Publisher: Springer
ISBN: 1493928953
Category : Science
Languages : en
Pages : 387
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Book Description
This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
Author:
Publisher: Springer Science & Business Media
ISBN: 3642729029
Category : Science
Languages : en
Pages : 137
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Book Description
Cholesterol is essential for normal cellular function. It is found in all cells of the body and is a major constituent of cell membranes. In addition, certain specialized tissues use cholesterol as the basic substrate for the synthesis of more complicated sterols such as bile acids and the steroid hormones. Like most lipids cholesterol has a very low solubility in water. Therefore, in order for these molecules to be transported be tween different organs of the body a series of lipid carriers known as lipoproteins has evolved. Over the last several years epidemiological evidence has accumulated suggest ing a strong relationship between the risk of atherosclerosis and high plasma concen trations of one of these lipoproteins, low density lipoprotein (LDL) 1). Thus, in popula tions with high plasma concentrations of LDL-cholesterol a correspondingly high incidence of vascular disease is seen. Since it has been demonstrated that reducing the steady-state plasma LDL-cholesterol concentration produces a proportional decrease in the risk of developing atherosclerosis 2), a major effort is now underway to develop safe and effective lipid lowering agents. In the past, these efforts have been hampered by a lack of knowledge concerning the physiological regulation of the plasma LDL-cholesterol concentration. However, recently there have been several major advances in these areas and it is now possible to precisely determine those factors that have the greatest effect on either increasing or decreasing the plasma LDL-cholesterol concentration.
Author:
Publisher: ScholarlyEditions
ISBN: 1464952213
Category : Science
Languages : en
Pages : 35
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Book Description
Lipoprotein Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Lipoprotein Receptors in a compact format. The editors have built Lipoprotein Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Lipoprotein Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Lipoprotein Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
