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Author: Thomas Unger
Publisher: Academic Press
ISBN: 0128014857
Category : Medical
Languages : en
Pages : 312
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Book Description
The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.
Author: Thomas Unger
Publisher: Academic Press
ISBN: 0128014857
Category : Medical
Languages : en
Pages : 312
Get Book Here
Book Description
The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.
Author: Sukhwinder K. Bhullar
Publisher: Springer Nature
ISBN: 3031236211
Category : Medical
Languages : en
Pages : 499
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Book Description
This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.
Author: Edward D. Frohlich
Publisher: Springer Science & Business Media
ISBN: 1441905286
Category : Medical
Languages : en
Pages : 187
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Book Description
Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system. Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.
Author: Hideshi Kobayashi
Publisher: Springer Science & Business Media
ISBN: 3642611648
Category : Science
Languages : en
Pages : 251
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Book Description
The renin-angiotensin system and the mechanisms regulating this system developed during the adaptive evolution of verte brates, along with many other systems involved in the in tegrated survival of the organism. Because animal species have evolved from common ancestral populations, a basis for the comparison of body structures and physiological processes ex ists among animal groups belonging to different classifications. The comparative approach provides a better understanding of the structure and function of adaptive systems and facilitates the development of general principles governing these systems among animal groups; further, this approach reveals significant characteristics specific to certain animal groups. As the evolu tion of adaptation of animals to environmental conditions is explored, directions for future research are suggested. In this book, advances in research on the renin-angiotensin system are described with emphasis on the comparative aspects. However, since studies on the renin-angiotensin system of birds, reptiles, amphibians and fishes are limited compared with those con ducted in mammals, in some chapters descriptions are con cerned primarily with mammals. It has taken a long time to write this volume, and the topic is a broad one, with new data always emerging; therefore, certain aspects, and sometimes the most recent information, may not be included. Chapters 1-3 and sections 8. 1-8. 4,8. 6, 8. 7 were written by H. K. ; Chapters 4-7 and Section 8. 5 by Y. T. ; Chapter 9 was written by both authors. H. Uemura, M. Nozaki, Y. Okawara, We are indebted to Drs.
Author: Aleksandar Kibel
Publisher: BoD – Books on Demand
ISBN: 1789854210
Category : Medical
Languages : en
Pages : 179
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Book Description
Selected Chapters from the Renin-Angiotensin System aims to provide a comprehensive overview of the most important physiological and pathophysiological roles of the renin-angiotensin system (RAS). The complex and convoluted RAS has been investigated for many years and, through rigorous scientific research, many important and previously unknown components and functions of the RAS have come to light. These discoveries have been crucial in the understanding of this system and provide a basis for effective modulation of the system as part of therapeutic strategies for a number of widespread disorders. New studies are continuing to elucidate the RAS and the mechanisms associated with its functions. This book discusses relevant scientific knowledge about the RAS and intends to introduce the reader to cutting-edge research with an accentuation on the mechanisms at the functional/physiological and molecular/cellular levels.
Author: Samy I. McFarlane
Publisher: BoD – Books on Demand
ISBN: 1839682868
Category : Medical
Languages : en
Pages : 170
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Book Description
The Renin-Angiotensin Aldosterone System (RAAS) plays an important role not only in salt and water homeostasis but also in the cardiovascular system, the kidney, and the brain. While several volumes address different aspects of the RAAS function, this book provides cutting-edge information on the pathogenesis of various disorders related to RAAS overactivation. It also presents unique aspects of RAAS functioning that have not been sufficiently described in the literature. Topics covered include assessment of hypoaldosteronism in infancy, RASS and cognitive decline, and the role of RAAS in the pathogenesis of COVID-19. Written by experts in the field in an easy-to-follow and illustrated format, this volume will benefit students and practitioners, as well as clinical and basic science investigators alike.
Author: Dulce Elena Casarini
Publisher: Bentham Science Publishers
ISBN: 1681083132
Category : Medical
Languages : en
Pages : 387
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Book Description
The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several peptides such as angiotensin I and II as well as angiotensin converting enzyme (ACE) to enable the constriction of arterial blood vessels in the lung. Angiotensin II also stimulates the production of the hormone aldosterone in the kidneys which brings sodium ions into the bloodstream in exchange for potassium ions. Malfunctions of the RAS can lead to hypertension, heart failure, diabetes and renal complications. Thus the biochemical components of this system serve as important targets for therapeutic drugs. This monograph is a compilation of updated reviews on the RAS. The monograph covers describes the components of the system to explaining its physiological and clinical features in the cardiovascular system and the kidneys. This is followed by sections explaining the biochemistry of the RAS system in cardiovascular and renal disease and the pharmacology of relevant therapeutic drugs. Additional information on the effect of exercise states and methods to quantify angiotensins for molecular diagnosis is also presented in the concluding sections. Information in the monograph will be of interest to physiologists and endocrinologists involved in medical studies or clinical practice. Readers will be able to understand the RAS with a holistic frame of reference.
Author: Walmor C. De Mello
Publisher: Wiley-Blackwell
ISBN:
Category : Family & Relationships
Languages : en
Pages : 268
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Book Description
Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed. Other topics covered include wound healing as well as the trophic effects of aldosterone. Contains the most recent findings on the renin angiotensin system and the heart Written by an international team of distinguished scientists Covers both the cellular and molecular basis of the renin angiotensin system and the clinical relevance of this research
Author: Ahsan Husain
Publisher: CRC Press
ISBN: 9789058230386
Category : Medical
Languages : en
Pages : 424
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Book Description
Since 1898, when Tigerstadt and Bergman first extracted renin from rabbit kidney, the reninrugs, Enzymes and Receptors of the Renin is designed to highlight molecular and clinical approaches to understanding the renin Chapter topics have been specifically chosen to cover selected contemporary, controversial and unresolved issues. A novel and unique feature of this book is that a commentary on each chapter, written by an independent peer or peers, is included to present alternative views, greater depth and a different perspective. Clinicians and researchers alike will find this volume a stimulating, and perhaps even entertaining, addition to their libraries. .
Author: Brijesh K. Tiwari
Publisher: Academic Press
ISBN: 0124199585
Category : Technology & Engineering
Languages : en
Pages : 488
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Book Description
Seaweed Sustainability: Food and Non-Food Applications is the only evidence-based resource that offers an abundance of information on the applications of seaweed as a solution to meet an increasing global demand for sustainable food source. The book uncovers seaweed potential and describes the various sources of seaweed, the role of seaweeds as a sustainable source for human food and animal feeds, and the role of seaweed farming for sustainability. In addition to harvesting and processing information, the book discusses the benefits of seaweed in human nutrition and its nutraceutical properties. Offers different perspectives by presenting examples of commercial utilization of wild-harvested or cultivated algae, marine and freshwater seaweeds Discusses seasonal and cultivar variations in seaweeds for a better understanding of their implications in commercial applications Includes a wide range of micro and macro algae for food and feed production and provides perspectives on seaweed as a potential energy source
