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Author: Frank Putnam
Publisher: Elsevier
ISBN: 0323161464
Category : Medical
Languages : en
Pages : 633
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Book Description
The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume III is an eight-chapter treatise that describes the plasma proteins in a systematic integrated manner. This book presents first the perspectives and global outlook at plasma proteins, followed by a series of chapters on the well-characterized major proteins, with particular emphasis on immunoglobulins. Other chapters are devoted to the integrated systems of plasma proteins, especially their structure, function, and genetic control. A chapter describes the plasma protein fractionation. The remaining chapters introduce the clinical relevance of the plasma proteins. This book will be of great value to biologists, geneticists, clinicians, and researchers.
Author: Frank Putnam
Publisher: Elsevier
ISBN: 0323161464
Category : Medical
Languages : en
Pages : 633
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Book Description
The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume III is an eight-chapter treatise that describes the plasma proteins in a systematic integrated manner. This book presents first the perspectives and global outlook at plasma proteins, followed by a series of chapters on the well-characterized major proteins, with particular emphasis on immunoglobulins. Other chapters are devoted to the integrated systems of plasma proteins, especially their structure, function, and genetic control. A chapter describes the plasma protein fractionation. The remaining chapters introduce the clinical relevance of the plasma proteins. This book will be of great value to biologists, geneticists, clinicians, and researchers.
Author: Frank W Putnam
Publisher: Elsevier
ISBN: 032313808X
Category : Medical
Languages : en
Pages : 498
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Book Description
The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume I is a systematic account of the structure, function, and genetic control of plasma proteins. Clinical relevance is introduced in terms of principles, with emphasis on human proteins. Animal proteins are also used as examples in some cases. Comprised of nine chapters, this volume begins with a historical background on plasma proteins, along with their nomenclature, characterization, and genetic markers. The primary structure and three-dimensional conformation of plasma proteins are also considered. The discussion then turns to the chemical, physical, and biological properties of various plasma proteins such as serum albumin, lipoproteins, and immunoglobulins. Subsequent chapters deal with protease inhibitors in plasma; purification, physical properties, chemical composition, and molecular structure of transferrin; biosynthesis and metabolism of serum lipoproteins; and physical, chemical, and functional properties of the proteins of the complement system. The final chapter is devoted to ?2-microglobulin, with particular reference to its purification and physical properties; chemical composition and structure; physiological function, biosynthesis, and catabolism; and presence and function in cell membranes. This monograph will be of interest to molecular biologists and biochemists.
Author: Frank Putnam
Publisher: Elsevier
ISBN: 032316174X
Category : Medical
Languages : en
Pages : 433
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Book Description
The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume V explores the contribution of molecular biology and gene cloning approaches to the advancement of plasma protein structure, function, and genomic organization studies. This volume is composed of five chapters and begins with a discussion on the DNA sequences and chromosomal location of plasma protein genes, specifically the cloning and sequencing of immunoglobulin genes. These topics are followed by a discussion on the advances in relation to discovered genetic variants present either as normal phenotypes or in dyslipoproteinemic states associated with cardiovascular disease. A chapter highlights the application of molecular biology techniques to the study of gene structure and the translational and maturation steps of every major plasma apolipoprotein. Another chapter emphasizes the unique features of protein structure and the conformational changes that characterize the assembly of macromolecular complexes in plasma and on cell surfaces. The concluding chapter provides a comprehensive review of the integration of molecular biology, physiology, and pathology of plasma proteins and their response in inflammation. This book will be of great value to molecular biologists, physiologists, pathologists, and clinicians.
Author: Frank Putnam
Publisher: Elsevier
ISBN: 0323161731
Category : Science
Languages : en
Pages : 439
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Book Description
The Plasma Proteins: Structure, Function, and Genetic Control is a systematic account of the structure, function, and genetic control of plasma proteins. Advances in the characterization and posttranslational modification of plasma proteins are discussed, along with the structure of a variety of plasma proteins such as serum albumin, glycoproteins, and serum lipoproteins, and immunoglobulins. Comprised of six chapters, this volume begins with a review of progress in plasma proteins, focusing on their three-dimensional structure, characterization, and microheterogeneity as well as genetic polymorphism and chromosomal mapping. The second chapter gives a comprehensive summary of the structure of nearly 100 proteins, from serum albumin and glycoproteins to serum lipoproteins, thyroxine-binding proteins, and immunoglobulins. The reader is then introduced to human plasma proteins of unknown function, together with high-resolution two-dimensional electrophoretic mapping. The remaining chapters explore developments in the structural study of carbon hydrates; synthesis, structure, and function of the oligosaccharides of plasma glycoproteins; and the evolution of the vertebrate plasma proteins. This monograph will be of interest to molecular biologists and biochemists.
Author: Hans Neurath
Publisher: Elsevier
ISBN: 0323162045
Category : Science
Languages : en
Pages : 696
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Book Description
The Proteins, Third Edition, Volume IV is a four-chapter text that explores the unifying concepts of protein chemistry and the methods of analysis that can be applied to most proteins. The first chapter deals with the biological origins and subsequent evolution of proteins. This chapter also provides the various procedures for comparing amino acid sequences and for establishing the relatedness of protein structures. A discussion on gene duplication as a principal vehicle of evolutionary change is also included in this chapter. Chapter 2 focuses on chromosomal proteins, such as those proteins associated with the genetic material of eukaryotic organisms, specifically the protamines, the histones, and the ""nonhistone"" proteins. Chapter 3 is devoted to contractile proteins of muscle. This chapter describes the molecular processes whereby chemical energy is converted into the mechanical energy required for the propulsion of living creatures. The structure and function of the individual proteins of the contractile apparatus and their organization as evidenced by light and electron microscopy and by X-ray analysis are also covered. Chapter 4 deals with collagen, an important constituent of the extracellular connective tissues in animals and one of the most abundant proteins. This chapter emphasizes the biosynthesis of collagen fibrils. Organic chemists and researchers, teachers and undergraduate students will find this book invaluable.
Author: Marcus Rothschild
Publisher: Elsevier
ISBN: 0323145183
Category : Science
Languages : en
Pages : 585
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Book Description
Plasma Protein Metabolism: Regulation of Synthesis, Distribution, and Degradation covers the concepts concerning the physiological and pathophysiological factors regulating the distribution, degradation, and synthesis of plasma proteins. This book is organized into nine parts encompassing 32 chapters. The first parts present the assumptions and methodology involved in the various in vivo and in vitro techniques that provide insights to protein metabolism. The next parts describe the techniques of protein isolation, characterization, labeling, and mathematical analysis of the data, as well as the methods for directly quantitating protein synthetic rates in nonsteady state conditions. Other parts are devoted to the factors involved in regulating the serum levels of albumin, acute phase reactants, immunoglobulins, clotting factors, complement and hormone-binding proteins. The controlling factors include such general and specific physiological regulators of protein synthesis and catabolism as levels of specific serum proteins, hormonal regulators, variations of temperature and oncotic pressure, antigenic stimulation, and nutritional factors. The remaining parts analyze the pathophysiological factors including disorders of protein synthesis, distribution, exogenous catabolism, and external loss and stress that produce abnormal levels of serum proteins. This book is intended primarily intended to protein chemists and researchers.
Author: Herbert Spiegel
Publisher: Elsevier
ISBN: 0323155529
Category : Medical
Languages : en
Pages : 335
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Book Description
Clinical Biochemistry: Contemporary Theories and Techniques, Volume 2 is a collection of papers that deals with coagulation chemistry, inborn errors of metabolism (IEM), and the biochemistry of aging. One paper explains the biochemistry and clinical importance of lipoprotein-X (LP-X) as a marker for obstructive jaundice and also as a pointer in the deficiency of lecithin-cholesterol acyltransferase (LCAT), a rare inborn error of metabolism. Another paper presents guidelines in determining radioimmunoassay that are used, for example, in identifying enzymes produced by various malignant lesions. One paper reviews the basic molecular events and interactions involved in the blood clotting process and its related systems. To determine inborn errors of metabolism, the investigator can use screening techniques, prenatal diagnosis or therapy, and laboratory procedures related to IEM. To correct errors at the gene level, transgenosis and genetic engineering use recombinant DNA research techniques involving the introduction of a foreign DNA into the host cell. Some examples of IEM are phenylketonuria and hyperphenylalaninemia without PKU. This collection can prove useful for the clinical chemists, endocrinologists, internists, medical practitioners, and investigators involved in research on biochemistry.
Author: R. Nezlin
Publisher: Springer Science & Business Media
ISBN: 1468417916
Category : Medical
Languages : en
Pages : 395
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Book Description
When the history of immunology in the twentieth century is written, the decade of the 1960's will, in all probability, stand out as the period of greatest advance in the development of molecular immunology. It is appropriate and useful, therefore, that a schol arly and integrated presentation of this progress should be made available in English. The translation of Dr. Nezlin's "Biochem istry of Antibodies" from Russian admirably fulfills this need in the form of a scientific monograph directed to medical and biolog ical scientists. The appearance of this monograph also serves to emphasize the conceptual unification of diverse immunological phenomena which has emerged from progress in molecular immunology. This unity is a consequence of the key role played by the antibody mol ecule (either in solution or cell-bound) in every biological process properly described as immunological. Indeed, immunology as an independent natural science can be described as the study of the structure, interactions, and biosynthes is of the antibody molecule.
Author: Louis Rosenfeld
Publisher: Elsevier
ISBN: 0323152929
Category : Science
Languages : en
Pages : 387
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Book Description
Origins of Clinical Chemistry: The Evolution of Protein Analysis covers the history of the application of analytical methods to the plasma protein analysis. This book is divided into 20 chapters that consider the relationship between the limitation of technical accuracy and clinical interpretation. The introductory chapters provide an overview of the concept and issues in protein chemistry, as well as the history of organic chemistry. The succeeding chapters deal with the classification, detection, fractionation, and analysis of proteins. Considerable chapters are devoted to various analytical techniques for protein analysis, including colorimetry, photometry, Svedberg technique, ultracentrifuging, zone electrophoresis, immunohistochemical methods, and radioimmunoassay. The remaining chapters examine the detection and analysis of proteins in several body fluids, such as urine and cerebrospinal fluid. This book will be of great value to clinical, analytical, and organic chemists, as well as to protein scientists and researchers.
Author: Samuel Natelson
Publisher: Springer Science & Business Media
ISBN: 1468435841
Category : Science
Languages : en
Pages : 562
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Book Description
This book, the third volume in the series, continues to explore the application of chemistry to our understanding of the functioning of the human in health and disease. It is the objective of the authors to continue to present, in this and subsequent volumes, the biochemical aspects of clinical chemistry, and to indicate how this knowledge applies to the diagnosis of disease and the treatment of the patient. For this purpose, the literature is reviewed carefully and the findings of the different study groups are integrated, to present an overall view of the present status of the various fields. The text is written with the intent to serve in the training of clinical chemists, clinical pathologists, and medical students in clinical biochemistry. It is also intended to serve as a reference text for the practicing physician who desires a more rational approach to the use of the clinical chemistry laboratory, as an aid in understanding (1) the chemical changes in disease and (2) the logical use of the laboratory data in the treatment of the patient. This volume is concerned with the plasma proteins and their significance in normal human metabolism. The immunoglobulins are not included in this study since, along with complement and clotting factors, they form an integrated system concerned with defense against invading organisms. These will be discussed in Volume 4 of this series. A historical introduction (Chapter I) is followed by a general presentation of the composition and properties of proteins (Chapter 2).
