The MTE, a New Core Promoter Element for Transcription by RNA Polymerase II PDF Download
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Author: Chin Yan Lim
Publisher:
ISBN:
Category :
Languages : en
Pages : 258
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Book Description
Author: Chin Yan Lim
Publisher:
ISBN:
Category :
Languages : en
Pages : 258
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Book Description
Author: Muyu Xu
Publisher:
ISBN:
Category : Genetic regulation
Languages : en
Pages : 178
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Book Description
Author: Jun Ma
Publisher: Springer
ISBN: 9781441922038
Category : Science
Languages : en
Pages : 0
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Book Description
This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.
Author: Katayoon Hojjati-Emami
Publisher:
ISBN:
Category :
Languages : en
Pages : 236
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Book Description
Author: Trevor John Parry
Publisher:
ISBN: 9781109703887
Category :
Languages : en
Pages : 41
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Book Description
The RNA polymerase II core promoter is a diverse and complex region of DNA that contains the transcription start site. Core promoter elements are conserved DNA sequences within the core promoter that direct transcription to the start site and function in the regulation of gene expression. Here I describe the TCT motif, a newly discovered core promoter element that encompasses the transcription start site and is conserved among the ribosomal protein genes. Mutational analysis of three ribosomal protein gene promoters, RpLP1, RpS12, and RpS15, demonstrates the importance of this DNA element. A severe down-regulation of transcription is seen when the wild-type sequence is mutated, with positions 3-5 (+3 to +5 relative to the +1 transcription start site) being the most important. I also show that the TCT does not work synergistically with other previously characterized core promoter elements, and the RpLP1 promoter is not bound by Transcription Factor IID (TFIID). The TCT is a necessary core promoter element for the transcription of the ribosomal protein genes. Its inability to work synergistically with other known promoter elements, along with its inability to bind TFIID, may suggest a parallel mechanism of RNA polymerase II transcription for the ribosomal protein genes that is independent of the mechanism used for all previously studied genes.
Author: Alias Jon Smith
Publisher:
ISBN:
Category :
Languages : en
Pages : 300
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Book Description
Author: Fumiaki Uchiumi
Publisher: BoD – Books on Demand
ISBN: 1789855179
Category : Medical
Languages : en
Pages : 202
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Book Description
Transcription is the most fundamental nuclear event, by which the information of nucleotide sequences on DNA is transcribed into RNA by multiple proteins, including RNA polymerases. Transcription determines the functions of proteins and the behaviour of cells, appropriately responding to environmental changes.This book is intended for scientists, especially those who are interested in the future prospect of gene expression and control in medicine and industry. This book consists of 9 chapters, divided into four parts. Each chapter is written by experts both in the basic and applied scientific field. A collection of articles presented by active and laboratory-based investigators provides evidence from the research, giving us a rigid platform to discuss "Gene Expression and Control."
Author: Lizabeth A. Allison
Publisher: John Wiley & Sons
ISBN: 1119156327
Category : Science
Languages : en
Pages : 816
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Book Description
Fundamental Molecular Biology Discover a focused and up to date exploration of foundational and core concepts in molecular biology The newly revised Third Edition of Fundamental Molecular Biology delivers a selective and precise treatment of essential topics in molecular biology perfect for allowing students to develop an accurate understanding of the applications of the field. The book applies the process of discovery-observations, questions, experimental designs, results, and conclusions-with an emphasis on the language of molecular biology. Readers will easily focus on the key ideas they need to succeed in any introductory molecular biology course. Fundamental Molecular Biology provides students with the most up to date techniques and research used by molecular biologists today. Readers of the book will have the support and resources they need to develop a concrete understanding of core and foundational concepts of molecular biology, without being distracted by outdated or peripheral material. Readers will also benefit from the inclusion of: A thorough introduction to and comparison of eukaryotic and prokaryotic organisms illustrating the variation of cellular processes across organisms Tool boxes exploring up to date experimental methods and techniques used by molecular biologists Focus boxes providing detailed treatment of topics that delve further into experimental strategies Disease boxes placing complex regulatory pathways in their relevant context and illustrating key principles of molecular biology Perfect for instructors and professors of introductory molecular biology courses, Fundamental Molecular Biology will also earn a place in the libraries of anyone seeking to improve their understanding of molecular biology with an insightful and well-grounded treatment of the core principles of the subject.
Author: Kenneth Berendzen
Publisher: Bentham Science Publishers
ISBN: 1608054926
Category : Science
Languages : en
Pages : 225
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Book Description
A major goal of integrative research is understanding regulatory networks to such an extent as to allow researchers to model developmental and stress responses. Regulatory networks of living systems include complex and vast interactions between proteins, metabolites, RNA, various signaling molecules and DNA. One aspect of systems biology is understanding the dynamics of protein-DNA interactions affecting gene expression that are caused by transcription factors (TFs) and chromatin remodeling factors. This e-book provides a resource for summarizing current knowledge eukaryotic transcription and explores cis-elements and methods for their analysis, prediction and discovery. The book also presents an overview of exploring gene regulatory networks, chromatin, and miRNAs. Information about state-of-the-art techniques for the determination of TF - cis-element interactions in vivo and in silico give cutting edge insights on how genomic-scale research is being approached. The Analysis of Regulatory DNA provides readers with both the necessary background knowledge and provocative, up-to-date insights aimed at sparking new and vibrant experimental designs for understanding and predicting cis-elements in the eukaryotic genome.
Author: Stanley Maloy
Publisher: Academic Press
ISBN: 0080961568
Category : Science
Languages : en
Pages : 4360
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Book Description
The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics
