Molecular Biology of The Cell PDF Download
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Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Richard Ivell
Publisher: Springer Science & Business Media
ISBN: 1461559138
Category : Medical
Languages : en
Pages : 335
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Book Description
THE FASCINATION The male germ cell is the only cell of the human organism that leaves the body when it has achieved its final, highly sophisticated structure and properties. The male germ cell is designed for one purpose only: to reach the female gametes and to fertilize them. The various stages in the development of the male germ cell are characterized by proliferative phases, by the recombination of the maternal and paternal chromosomes, and by the differentiation and development of a specialized transport vehicle, the spermato zoon. Furthermore, the establishment of a special pool of stem cells, the spermatogonia, guarantees the continuity of the sperm-generation process from puberty to old age. THE FATE OF THE MALE GERM CELL The destiny of any individual germ cell is determined by a program that we know only in fragments. On the one hand every human male is able to produce many billions of germ cells in his lifetime, yet the chance of any single sperm reaching and fertilizing the female germ cell is exceedingly rare. A fertility disturbance means that somewhere during the complicated playing out of the germ cell program mistakes are made, and the program fails. It is still a fact that more than 50% of men presenting with male factor infertility have to be diagnosed as idiopathic, largely because of our lack of knowledge and conse quent lack of appropriate diagnostic tools.
Author: Yun-Fai Chris Lau
Publisher: World Scientific
ISBN: 9812770437
Category : Medical
Languages : en
Pages : 323
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Book Description
The roles of mouse Y chromosome genes in spermatogenesis -- Male meiotic sex chromosome inactivation and meiotic silencing -- Insights into SRY action from sex reversal mutations -- The TSPY gene family -- Structure and function of AZFa locus in human spermatogenesis -- RBMY and DAZ in spermatogenesis -- Neurotrophic factors in the development of the postnatal male germ line -- Dickkopf-like 1-a protein unique to mammals that is associated both with formation of trophoblast stem cells and with spermatogenesis -- Antisense transcription in developing male germ cells -- The spermatogonial stem cell model -- Transplantation of germ cells and testis tissue -- Orthodox and unorthodox ways to initiate fertilization and development in mammals -- Pathogenesis of testicular germ cell tumors -- Origin of testicular germ cell neoplasia: the role of sex chromosomes.
Author: Bernard Robaire
Publisher:
ISBN:
Category :
Languages : en
Pages : 510
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Book Description
Author: Lonnie Dee Russell
Publisher:
ISBN:
Category : Sertoli cells
Languages : en
Pages : 840
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Book Description
Author: P.H. Vogt
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318060984
Category : Medical
Languages : en
Pages : 190
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Book Description
Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.
Author: Paul de Kruif
Publisher:
ISBN:
Category :
Languages : en
Pages : 243
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Book Description
Author: Kyle E. Orwig
Publisher: Springer Science & Business Media
ISBN: 1617379735
Category : Science
Languages : en
Pages : 269
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Book Description
Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.
Author: Hans-Jürgen Glander
Publisher:
ISBN: 9783832276850
Category : Andrology
Languages : en
Pages : 456
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Book Description
Author: Michael K. Skinner
Publisher: Elsevier
ISBN: 0080492282
Category : Science
Languages : en
Pages : 511
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Book Description
Sertoli cells assist in the production of sperm in the male reproductive system. This book provides a state-of-the-art update on the topic of sertoli cells and male reproduction. It addresses such highly topical areas as stem cells, genomics, and molecular genetics, as well as provides historical information on the discovery of this type of cell, and the pathophysiology of male infertility. * Presents the state-of-the-art research on topics such as stem cell research, transplantation and genomics* Includes contributions from leaders in the field, including several members of the National Academy of Science
