The Importance of Core Promoter Structure in the Transcriptional Regulation of the Terminal Deoxynucleotidyltransferase Gene PDF Download
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Author: Isla P. Garraway
Publisher:
ISBN:
Category :
Languages : en
Pages : 242
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Book Description
Author: Isla P. Garraway
Publisher:
ISBN:
Category :
Languages : en
Pages : 242
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Book Description
Author: Kiersten P. Lo
Publisher:
ISBN:
Category :
Languages : en
Pages : 358
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Author: Trevor John Parry
Publisher:
ISBN: 9781109703887
Category :
Languages : en
Pages : 41
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Book Description
The RNA polymerase II core promoter is a diverse and complex region of DNA that contains the transcription start site. Core promoter elements are conserved DNA sequences within the core promoter that direct transcription to the start site and function in the regulation of gene expression. Here I describe the TCT motif, a newly discovered core promoter element that encompasses the transcription start site and is conserved among the ribosomal protein genes. Mutational analysis of three ribosomal protein gene promoters, RpLP1, RpS12, and RpS15, demonstrates the importance of this DNA element. A severe down-regulation of transcription is seen when the wild-type sequence is mutated, with positions 3-5 (+3 to +5 relative to the +1 transcription start site) being the most important. I also show that the TCT does not work synergistically with other previously characterized core promoter elements, and the RpLP1 promoter is not bound by Transcription Factor IID (TFIID). The TCT is a necessary core promoter element for the transcription of the ribosomal protein genes. Its inability to work synergistically with other known promoter elements, along with its inability to bind TFIID, may suggest a parallel mechanism of RNA polymerase II transcription for the ribosomal protein genes that is independent of the mechanism used for all previously studied genes.
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 856
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Author: Michael F. Carey
Publisher: CSHL Press
ISBN: 9780879696351
Category : Medical
Languages : en
Pages : 684
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Book Description
In the genome era, the analysis of gene expression has become a critical requirement in many laboratories. But there has been no comprehensive source of strategic, conceptual, and technical information to guide this often complex task. Transcriptional Regulation in Eukaryotes answers that need. Written by two experienced investigators, Michael Carey and Stephen Smale at the UCLA School of Medicine, and based in part on the Gene Expression course taught at Cold Spring Harbor Laboratory, this book directly addresses all the concerns of a laboratory studying the regulation of a newly isolated gene and the biochemistry of a new transcription factor. This important and unique book is essential reading for anyone pursuing the analysis of gene expression in model systems or disease states.
Author: Patricia Ann Ernst
Publisher:
ISBN:
Category :
Languages : en
Pages : 244
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Book Description
Author: Amy Susan Weinmann
Publisher:
ISBN:
Category :
Languages : en
Pages : 334
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Book Description
Author: Branden S. Wolner
Publisher:
ISBN:
Category :
Languages : en
Pages : 192
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1828
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Book Description
Author: Gary D. Kruh
Publisher: Springer Science & Business Media
ISBN: 1468484370
Category : Medical
Languages : en
Pages : 288
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Book Description
In recent years, great strides have been made in the field of cancer research. Now, with Basic Science of Cancer, a range of interrelated topics such as tumor suppressor genes, apoptosis, transcriptional regulation, pharmacology of anticancer drugs, cytogenetic techniques, oncogenes, and signal transduction are thoroughly addressed. Written for oncologists and healthcare professionals, this new comprehensive reference also discusses modern research techniques used to investigate the molecular etiology and treatment of human cancer. Topics are described using nontechnical terms. Together, complete reference listings and over 200 illustrations provide an extensive, yet introductory, look into the complex field of cancer.
