Author: Peter van den Elsen
Publisher: Springer Science & Business Media
ISBN: 3662224941
Category : Medical
Languages : en
Pages : 217
Book Description
these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec tron-dense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep tion of the DR a-chain, all other MHC class II a and 13 chains are poly morphic.
The Human T-Cell Receptor Repertoire and Transplantation
Author: Peter van den Elsen
Publisher: Springer Science & Business Media
ISBN: 3662224941
Category : Medical
Languages : en
Pages : 217
Book Description
these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec tron-dense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep tion of the DR a-chain, all other MHC class II a and 13 chains are poly morphic.
Publisher: Springer Science & Business Media
ISBN: 3662224941
Category : Medical
Languages : en
Pages : 217
Book Description
these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec tron-dense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep tion of the DR a-chain, all other MHC class II a and 13 chains are poly morphic.
The Human T Cell Receptor Repertoire
Author: Gail Elaine Hawes
Publisher:
ISBN:
Category :
Languages : en
Pages : 159
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 159
Book Description
Immunodeficiency and Generation of the Human T Cell Receptor Repertoire
Author: Christopher Pickard
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages :
Book Description
A Most Elegant Equation
Author: David Stipp
Publisher: Hachette UK
ISBN: 0465093787
Category : Mathematics
Languages : en
Pages : 240
Book Description
An award-winning science writer introduces us to mathematics using the extraordinary equation that unites five of mathematics' most important numbers Bertrand Russell wrote that mathematics can exalt "as surely as poetry." This is especially true of one equation: ei(pi) + 1 = 0, the brainchild of Leonhard Euler, the Mozart of mathematics. More than two centuries after Euler's death, it is still regarded as a conceptual diamond of unsurpassed beauty. Called Euler's identity or God's equation, it includes just five numbers but represents an astonishing revelation of hidden connections. It ties together everything from basic arithmetic to compound interest, the circumference of a circle, trigonometry, calculus, and even infinity. In David Stipp's hands, Euler's identity formula becomes a contemplative stroll through the glories of mathematics. The result is an ode to this magical field.
Publisher: Hachette UK
ISBN: 0465093787
Category : Mathematics
Languages : en
Pages : 240
Book Description
An award-winning science writer introduces us to mathematics using the extraordinary equation that unites five of mathematics' most important numbers Bertrand Russell wrote that mathematics can exalt "as surely as poetry." This is especially true of one equation: ei(pi) + 1 = 0, the brainchild of Leonhard Euler, the Mozart of mathematics. More than two centuries after Euler's death, it is still regarded as a conceptual diamond of unsurpassed beauty. Called Euler's identity or God's equation, it includes just five numbers but represents an astonishing revelation of hidden connections. It ties together everything from basic arithmetic to compound interest, the circumference of a circle, trigonometry, calculus, and even infinity. In David Stipp's hands, Euler's identity formula becomes a contemplative stroll through the glories of mathematics. The result is an ode to this magical field.
Janeway's Immunobiology
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Advances in Human Immune System (HIS) Mouse Models for Studying Human Hematopoiesis and Cancer Immunotherapy
Author: Yasuyuki Saito
Publisher: Frontiers Media SA
ISBN: 2889743187
Category : Medical
Languages : en
Pages : 253
Book Description
Topic Editor Prof. Aimin Xu receives financial support from Servier Laboratories. The other Topic Editors declare no competing interests with regards to the Research Topic theme.
Publisher: Frontiers Media SA
ISBN: 2889743187
Category : Medical
Languages : en
Pages : 253
Book Description
Topic Editor Prof. Aimin Xu receives financial support from Servier Laboratories. The other Topic Editors declare no competing interests with regards to the Research Topic theme.
Molecular Biology of The Cell
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
Book Description
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
Book Description
T-cell Receptor Use in Human Autoimmune Diseases
Author: Mark M. Davis
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 488
Book Description
Animal models of some autoimmune diseases have indicated restricted T-cell receptor use and have suggested therapies based on those data. Patients with naturally occurring diseases have not shown a consistent picture of receptor utilisation. This volume discusses the spectrum of T-cell receptor use in human disease, the relationship between the human and animal findings, and the biological and therapeutic implications of the former.
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 488
Book Description
Animal models of some autoimmune diseases have indicated restricted T-cell receptor use and have suggested therapies based on those data. Patients with naturally occurring diseases have not shown a consistent picture of receptor utilisation. This volume discusses the spectrum of T-cell receptor use in human disease, the relationship between the human and animal findings, and the biological and therapeutic implications of the former.
Characterization of the T Cell and T Cell Receptor Repertoire Involved in Human Kidney Allograft Rejection
Author: M. Carrie Miceli
Publisher:
ISBN:
Category : Homografts
Languages : en
Pages : 296
Book Description
Publisher:
ISBN:
Category : Homografts
Languages : en
Pages : 296
Book Description
Next-Generation Sequencing of Human Antibody Repertoires for Exploring B-cell Landscape, Antibody Discovery and Vaccine Development
Author: Jacob Glanville
Publisher: Frontiers Media SA
ISBN: 2889639517
Category :
Languages : en
Pages : 231
Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Publisher: Frontiers Media SA
ISBN: 2889639517
Category :
Languages : en
Pages : 231
Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.