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Author: Bryan Sykes
Publisher: Oxford University Press, USA
ISBN: 9780198502746
Category : Science
Languages : en
Pages : 218
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Book Description
Very little excites human curiosity quite so much as contemplating human origins. More than any other branch of science, evolution - and human evolution in particular - is fraught with controversy. Working from what is essentially the same data, schools of opinion have come to diametrically opposed conclusions. Are we adapted Neanderthals, or a new species altogether which wiped them out? Did the first Americans enter the continent 30,000 or 12,000 years ago? Did the Polynesians sail against wind and current to an unknown fate, or were they just blown across from South America while out fishing? Why do we speak different languages? Is it because language traces our biological history, or are the two things completely unrelated? Evolution, because it deals with a past that can never conclusively be known, was once ideal material for perpetual debate. Enter genetics with a completely new source of objective data. Surely these old questions would soon be settled one way or another. Or would they? Bryan Sykes brings together a world-class set of contributors to debate these questions. The result is eight lively essays, each of which offers a different opinion about what the links between genes, language, and the archaeological record can tell us about human evolution - and indeed, whether they can tell us anything conclusive at all. This stimulating and challenging book poses more questions than it offers answers, eschews jargon, and pursues controversy. Guaranteed to fascinate anyone who has ever wondered how the fossil record, the incredible diversity of human language, and our genetic inheritance might combine to give a glimpse of human origins. Edited by Bryan Sykes, Institute of Molecular Medicine, University of Oxford. Publisher's note.
Author: Bryan Sykes
Publisher: Oxford University Press, USA
ISBN: 9780198502746
Category : Science
Languages : en
Pages : 218
Get Book Here
Book Description
Very little excites human curiosity quite so much as contemplating human origins. More than any other branch of science, evolution - and human evolution in particular - is fraught with controversy. Working from what is essentially the same data, schools of opinion have come to diametrically opposed conclusions. Are we adapted Neanderthals, or a new species altogether which wiped them out? Did the first Americans enter the continent 30,000 or 12,000 years ago? Did the Polynesians sail against wind and current to an unknown fate, or were they just blown across from South America while out fishing? Why do we speak different languages? Is it because language traces our biological history, or are the two things completely unrelated? Evolution, because it deals with a past that can never conclusively be known, was once ideal material for perpetual debate. Enter genetics with a completely new source of objective data. Surely these old questions would soon be settled one way or another. Or would they? Bryan Sykes brings together a world-class set of contributors to debate these questions. The result is eight lively essays, each of which offers a different opinion about what the links between genes, language, and the archaeological record can tell us about human evolution - and indeed, whether they can tell us anything conclusive at all. This stimulating and challenging book poses more questions than it offers answers, eschews jargon, and pursues controversy. Guaranteed to fascinate anyone who has ever wondered how the fossil record, the incredible diversity of human language, and our genetic inheritance might combine to give a glimpse of human origins. Edited by Bryan Sykes, Institute of Molecular Medicine, University of Oxford. Publisher's note.
Author: Nicholas Wade
Publisher: Penguin
ISBN: 0698163796
Category : Science
Languages : en
Pages : 249
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Book Description
Drawing on startling new evidence from the mapping of the genome, an explosive new account of the genetic basis of race and its role in the human story Fewer ideas have been more toxic or harmful than the idea of the biological reality of race, and with it the idea that humans of different races are biologically different from one another. For this understandable reason, the idea has been banished from polite academic conversation. Arguing that race is more than just a social construct can get a scholar run out of town, or at least off campus, on a rail. Human evolution, the consensus view insists, ended in prehistory. Inconveniently, as Nicholas Wade argues in A Troublesome Inheritance, the consensus view cannot be right. And in fact, we know that populations have changed in the past few thousand years—to be lactose tolerant, for example, and to survive at high altitudes. Race is not a bright-line distinction; by definition it means that the more human populations are kept apart, the more they evolve their own distinct traits under the selective pressure known as Darwinian evolution. For many thousands of years, most human populations stayed where they were and grew distinct, not just in outward appearance but in deeper senses as well. Wade, the longtime journalist covering genetic advances for The New York Times, draws widely on the work of scientists who have made crucial breakthroughs in establishing the reality of recent human evolution. The most provocative claims in this book involve the genetic basis of human social habits. What we might call middle-class social traits—thrift, docility, nonviolence—have been slowly but surely inculcated genetically within agrarian societies, Wade argues. These “values” obviously had a strong cultural component, but Wade points to evidence that agrarian societies evolved away from hunter-gatherer societies in some crucial respects. Also controversial are his findings regarding the genetic basis of traits we associate with intelligence, such as literacy and numeracy, in certain ethnic populations, including the Chinese and Ashkenazi Jews. Wade believes deeply in the fundamental equality of all human peoples. He also believes that science is best served by pursuing the truth without fear, and if his mission to arrive at a coherent summa of what the new genetic science does and does not tell us about race and human history leads straight into a minefield, then so be it. This will not be the last word on the subject, but it will begin a powerful and overdue conversation.
Author: G. Bradley Schaefer
Publisher: McGraw Hill Professional
ISBN: 0071819282
Category : Medical
Languages : en
Pages : 385
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Book Description
A complete introductory text on how to integrate basic genetic principles into the practice of clinical medicine Medical Genetics is the first text to focus on the everyday application of genetic assessment and its diagnostic, therapeutic, and preventive implications in clinical practice. It is intended to be a text that you can use throughout medical school and refer back to when questions arise during residency and, eventually, practice. Medical Genetics is written as a narrative where each chapter builds upon the foundation laid by previous ones. Chapters can also be used as stand-alone learning aids for specific topics. Taken as a whole, this timely book delivers a complete overview of genetics in medicine. You will find in-depth, expert coverage of such key topics as: The structure and function of genes Cytogenetics Mendelian inheritance Mutations Genetic testing and screening Genetic therapies Disorders of organelles Key genetic diseases, disorders, and syndromes Each chapter of Medical Genetics is logically organized into three sections: Background and Systems – Includes the basic genetic principles needed to understand the medical application Medical Genetics – Contains all the pertinent information necessary to build a strong knowledge base for being successful on every step of the USMLE Case Study Application – Incorporates case study examples to illustrate how basic principles apply to real-world patent care Today, with every component of health care delivery requiring a working knowledge of core genetic principles, Medical Genetics is a true must-read for every clinician.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309070864
Category : Nature
Languages : en
Pages : 348
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Book Description
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author: The Royal Society
Publisher: National Academies Press
ISBN: 0309671132
Category : Medical
Languages : en
Pages : 239
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Book Description
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Author: Robert A. Paul
Publisher: University of Chicago Press
ISBN: 022624086X
Category : Psychology
Languages : en
Pages : 364
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Book Description
Nearly everyone would agree that humans and their societies evolved by natural selection, that humans are biologically a single species but societies vary greatly, and neither genetic inheritance nor cultural inheritance alone can fully explain humans and their social systems. While there is a literature that addresses dual inheritance theory or the coevolution of culture and genetics, almost all of it is written from a perspective that accepts the neo-Darwinian evolutionary framework but does not give proper weight to social and cultural theory as it has been developed by cultural anthropologists. At the same time, cultural anthropologists have ignored the question of dual inheritance altogether, leaving the theorizing of how it works almost exclusively in the hands of those with a strong biological viewpoint. In this book anthropologist and psychoanalyst Robert Paul attempts to reconcile evolutionary and cultural approaches in anthropology through a comparative ethnographic exploration of how humans receive behavioral instructions from two separate channelsthe genetic code carried in the DNA and the symbolic systems that constitute culture. He develops a dual inheritance model that aims to do justice to both the genetic and cultural channels of inheritance. Paul elaborates his model of the relationship between genes and cultural symbols and then shows how it can make sense of both the similarities and variations found in human social life as captured in the now very extensive ethnographic record. He argues that cultural systems evolve to manage intra-group competition that would ensue from the genetic program pursuing its interests. The book uses thick descriptions and heavy interpretations from the ethnographic record to demonstrate how different societies tackle this challenge. The book fills a niche, connecting the dual-inheritance literature and symbolic cultural anthropology, using insights from the former to detect patterns in the latter. This is a rare and well-researched project, and should receive a broad readership among biological and cultural anthropologists, and students of human nature more broadly."
Author: Alfred Henry Sturtevant
Publisher: CSHL Press
ISBN: 9780879696078
Category : Medical
Languages : en
Pages : 190
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Book Description
In the small “Fly Room†at Columbia University, T.H. Morgan and his students, A.H. Sturtevant, C.B. Bridges, and H.J. Muller, carried out the work that laid the foundations of modern, chromosomal genetics. The excitement of those times, when the whole field of genetics was being created, is captured in this book, written in 1965 by one of those present at the beginning. His account is one of the few authoritative, analytic works on the early history of genetics. This attractive reprint is accompanied by a website, http://www.esp.org/books/sturt/history/ offering full-text versions of the key papers discussed in the book, including the world's first genetic map.
Author: Françoise Baylis
Publisher: Harvard University Press
ISBN: 0674976711
Category : Science
Languages : en
Pages : 305
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Book Description
A leading bioethicist offers critical insights into the scientific, ethical, and political implications of human genome editing. Designer babies, once found only in science fiction, have become a reality. We are entering a new era of human evolution with the advent of a technology called CRISPR, which allows scientists to modify our genes. Although CRISPR shows great promise for therapeutic use, it raises thorny ethical, legal, political, and societal concerns because it can be used to make permanent changes to future generations. What if changes intended for the good turn out to have unforeseen negative effects? What if the divide between the haves and have-nots widens as a result? Who decides whether we genetically modify human beings and, if so, how? Françoise Baylis insists that we must all have a role in determining our future as a species. The scientists who develop and use genome-editing tools should not be the only ones making decisions about future uses of the technology. Such decisions must be the fruit of a broad societal consensus. Baylis argues that it is in our collective interest to assess and steer the development and implementation of biomedical technologies. Members of the public with different interests and diverse perspectives must be among the decision makers; only in this way can we ensure that societal concerns are taken into account and that responsible decisions are made. We must be engaged and informed, think critically, and raise our voices as we create our future together. Sharp, rousing, timely, and thought-provoking, Altered Inheritance is essential reading. The future of humanity is in our hands.
Author:
Publisher:
ISBN:
Category : Abnormalities, Human
Languages : en
Pages : 104
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Book Description
Author: Jack J. Pasternak
Publisher: John Wiley & Sons
ISBN: 047171917X
Category : Science
Languages : en
Pages : 656
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Book Description
An Introduction to Human Molecular Genetics Second Edition Jack J. Pasternak The Second Edition of this internationally acclaimed text expandsits coverage of the molecular genetics of inherited human diseaseswith the latest research findings and discoveries. Using a unique,systems-based approach, the text offers readers a thoroughexplanation of the gene discovery process and how defective genesare linked to inherited disease states in major organ and tissuesystems. All the latest developments in functional genomics,proteomics, and microarray technology have been thoroughlyincorporated into the text. The first part of the text introduces readers to the fundamentalsof cytogenetics and Mendelian genetics. Next, techniques andstrategies for gene manipulation, mapping, and isolation areexamined. Readers will particularly appreciate the text'sexceptionally thorough and clear explanation of genetic mapping.The final part features unique coverage of the molecular geneticsof distinct biological systems, covering muscle, neurological, eye,cancer, and mitochondrial disorders. Throughout the text, helpfulfigures and diagrams illustrate and clarify complex material. Readers familiar with the first edition will recognize the text'ssame lucid and engaging style, and will find a wealth of new andexpanded material that brings them fully up to date with a currentunderstanding of the field, including: * New chapters on complex genetic disorders, genomic imprinting,and human population genetics * Expanded and fully revised section on clinical genetics, coveringdiagnostic testing, molecular screening, and varioustreatments This text is targeted at upper-level undergraduate students,graduate students, and medical students. It is also an excellentreference for researchers and physicians who need a clinicallyrelevant reference for the molecular genetics of inherited humandiseases.
