Author: Frederic Lawrence Holmes
Publisher: Oxford University Press, USA
ISBN: 0195070720
Category : Biochemistry
Languages : en
Pages : 512
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Book Description
The biography of one of the world's foremost biochemists, which traces his scientific career and his discoveries of the urea cycle and the citric acid cycle. The text makes use of five years of interviews with Hans Krebs, and a complete set of Krebs' key laboratory notebooks.
Author: Frederic Lawrence Holmes
Publisher:
ISBN:
Category :
Languages : en
Pages : 491
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Book Description
Author: Frederic Lawrence Holmes
Publisher:
ISBN:
Category :
Languages : de
Pages : 491
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Book Description
Author: Frederic Lawrence Holmes
Publisher: Yale University Press
ISBN: 9780300129687
Category : Science
Languages : en
Pages : 268
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Book Description
This fascinating book is an investigation of scientific creativity. Following the research pathways of outstanding scientists over the past three centuries, it finds common features in their careers and their landmark discoveries and sheds light on the nature of long-term experimental research. Frederic Lawrence Holmes begins by discussing various approaches to the historical study of scientific practice. He then explains three kinds of analysis of the individual scientific life: broad-scale, which examines the phases of a scientist’s career—apprenticeship, mastery, distinction, and maturity—over a lifetime; middle-scale, which explores the episodes within such a career; and fine-scale, which scrutinizes laboratory notebooks and other data to focus on the daily interplay between thought and operation. Using these analyses, Holmes presents rich examples from his studies of six preeminent scientists: Antoine-Laurent Lavoisier, Claude Bernard, Hans Krebs, Matthew Meselson, Franklin Stahl, and Seymour Benzer. The similar themes that he finds in their work and careers lead him to valuable insights into enduring issues and problems in understanding the scientific process.
Author: John E. Lesch
Publisher:
ISBN: 019518775X
Category : Medical
Languages : en
Pages : 377
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Book Description
In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research.
Author: Tanya O'Sullivan
Publisher: University of Pittsburgh Press
ISBN: 0822987058
Category : Science
Languages : en
Pages : 376
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Book Description
Dublin at the turn of the twentieth century was both the second city of the British Empire and the soon-to-be capital of an emerging nation, presenting a unique space in which to examine the past relationship between science and the city. Drawing on both geography and biography, Geographies of City Science underscores the crucial role urban spaces played in the production of scientific knowledge. Each chapter explores the lives of two practitioners from one of the main religious and political traditions in Dublin (either Protestant and Unionist or Catholic and Nationalist). As Tanya O’Sullivan argues, any variation in their engagement with science had far less to do with their affiliations than with their “life spaces”—domains where human agency and social structures collide. Focusing on nineteenth-century debates on the origins of the universe as well as the origins of form, humans, and language, O’Sullivan explores the numerous ways in which scientific meaning relating to origin theories was established and mobilized in the city. By foregrounding Dublin, her book complements more recent attempts to enrich the historiography of metropolitan science by examining its provenance in less well-known urban centers.
Author: Frederic Lawrence Holmes
Publisher: Oxford University Press
ISBN: 0195360389
Category : Science
Languages : en
Pages : 498
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Book Description
This comprehensive volume completes Frederic Holmes' notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs' research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and of the scientific process as a whole. The first volume, published in 1991, covered Krebs' formative years in Germany, his work with Otto Warburg, and his discovery of the urea cycle in 1932. This second volume reconstructs the investigative pathway and the professional and personal life of Hans Krebs, from the time of his arrival in England in 1933 until 1937, when he made the discovery for which he is best known--the formulation of the citric acid cycle. Holmes portrays Krebs' activity at the intimate level of daily interactions of thought and action, from which the characteristic patterns of scientific creativity can best be seen. Holmes' fascinating portrait of Krebs integrates the great scientist's investigative pathways with his personal life. The result is an illuminating analysis of both man and scientist that will be of interest to biochemists and historians of science.
Author: John Krige
Publisher: Routledge
ISBN: 113440686X
Category : History
Languages : en
Pages : 978
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Book Description
With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe, and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.
Author: John Krige
Publisher: Taylor & Francis
ISBN: 9780415286060
Category : History
Languages : en
Pages : 988
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Book Description
This work on science in the 20th century represents work in America, Europe and Asia. It includes such topics as the countries that have made the most significant contributions, the relationship between science and industry and the importance of instrumentation.
Author: John Krige
Publisher: Routledge
ISBN: 1136483322
Category : History
Languages : en
Pages : 979
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Book Description
With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.
