The Effects of Neuropeptide Y (NPY) and Related Peptides on Smooth Muscle Cells Isolated from the Gastrointestinal Tract PDF Download
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Author: Sudhakar Misra
Publisher:
ISBN:
Category :
Languages : en
Pages : 314
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Book Description
Author: Sudhakar Misra
Publisher:
ISBN:
Category :
Languages : en
Pages : 314
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Book Description
Author: Edwin E. Daniel
Publisher: CRC Press
ISBN: 1000696987
Category : Science
Languages : en
Pages : 563
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Book Description
First published in 1991: This book assimilates and evaluates the rapidly accumulating information regarding neuropeptides in the gut, their chemistry; genetic control; processing in enteric nerves; the projections of their nerves; their actions at the tissue, cell, and molecular levels; and their roles in controlling gut motility in health and disease. Neuropeptide Function in the Gastrointestinal Tract is directed to scientists in all disciplines who work with neuropeptides, as well as physiologists interested in the neural and smooth muscle actions of neuropeptides.
Author: Lars Grundemar
Publisher: Elsevier
ISBN: 0080537456
Category : Medical
Languages : en
Pages : 242
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Book Description
Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions. This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance. This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets. The hypothalamic role of NPY and its relationship with eating disorders and diabetes The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology Development of peptide and non-peptide receptor antagonists
Author: Daniel L. Small
Publisher:
ISBN:
Category : Neuropeptide Y.
Languages : en
Pages : 282
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Book Description
Author: Martin C. Michel
Publisher: Springer Science & Business Media
ISBN: 3642187641
Category : Medical
Languages : en
Pages : 556
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Book Description
After a little more than 20 years since the original discovery of neuropeptide Y (NPY) by Tatemoto and colleagues, the field of NPY research has made remarkable progress and is coming of age.The present volume addresses all major topics in connection with NPY and related peptides by established leaders in their respective areas. Experienced NPY-aficionados will certainly find new and useful additional information in this volume and newcomers to the field will hopefully discover how much exciting research this still has to offer.
Author: Ambikaipakan Balasubramaniam
Publisher: Springer Science & Business Media
ISBN: 159259042X
Category : Medical
Languages : en
Pages : 244
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Book Description
The observation that neuropeptide Y (NPY) is the most abundant peptide present in the mammalian nervous system and the finding that it elicits the most powerful orexigenic signal have led to active investigations of the properties of the NPY family of hormones, including peptide YY (PYY) and pancreatic polypeptide (PP). Nearly two decades of research have led to the identification of several NPY receptor subtypes and the development of useful receptor selective ligands. Moreover, these investigations have imp- cated NPY in the pathophysiology of a number of diseases, including feeding disorders, seizures, memory loss, anxiety, depression, and heart failure. Vigorous efforts are therefore continuing, not only to understand the bioche- cal aspects of NPY actions, but also toward developing NPY-based treatments for a variety of disorders. To facilitate these efforts, it was decided to produce the first handbook on NPY research techniques as part of the Methods in Molecular Biology Series. In compiling Neuropeptide Y Protocols, I have gathered contributions on techniques considered critical for the advancement of the NPY field from experts in various disciplines. Each chapter starts with a brief introduction, with Materials and Methods sections following. The latter sections are presented in an easy to follow step-by-step format. The last section of the chapter, Notes, highlights pitfalls and the maneuvers employed to overcome them. This information, not usually disseminated in standard research pub- cations, may prove extremely useful for investigators employing these te- niques in NYP research.
Author: Steven L. Parker
Publisher:
ISBN: 9781626184213
Category : Neuropeptide Y
Languages : en
Pages : 0
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Book Description
This book presents a broad summary of current knowledge concerning the structure and biochemistry of neuropeptide Y in relation to its role in feeding and interactions with receptors, transducers, effectors and channels that can also connect to food intake. The very high conservation of NPY sequence indicates its critical importance in basal metabolic regulation. Mutations connecting to NPY are virtually absent, and those affecting the Y1 and Y2 receptors are very few. From the evidence presented across vertebrate classes, NPY appears mainly as metabotropic driver via the Y1 group of receptors, and its negative metabotropicity through the Y2 receptor is only of importance in the mammal, and then tempered by Y2 receptor masking in the hypothalamus and low numbers in the cortex, and by low availability of NPY outside the forebrain. Anatomically, NPY is well-represented especially in limbic areas of the forebrain, but the feeding-critical presence of Y1 receptors is, at least in the rodent, highest in the neocortex, and evidence presented in this book points to much larger involvement of cortical NPY receptors in feeding regulation than is usually perceived. The strong presence of this highly conserved peptide in the vertebrate forebrain is increasingly documented as linked not only to the regulation of glucose metabolism (and insulin activity), but also as directly involved in the operation of transducers, effectors and channels. This should be enabled especially by the high interactivity of the acidic sector of NPY (which is not shared by NPY-related systemic peptides, peptide YY and pancreatic polypeptide), and results in partial agonism and possibly also in accumulation in the bilayer. NPY could be involved as a helper agonist in several parts of the vertebrate metabolome.
Author: Zofia Zukowska
Publisher: Springer Science & Business Media
ISBN: 9783764371555
Category : Medical
Languages : en
Pages : 302
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Book Description
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists which are in clinical development for obesity while NPY Y1 receptors are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders are also actively pursued. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders, written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
Author: Alan A. Boulton
Publisher: Humana
ISBN:
Category : Medical
Languages : en
Pages : 616
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Book Description
Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscrentists, and those that are available often seem either out of date or limited in scope. This series is about the methods most widely used by modern-day neuroscientists and 1s written by their colleagues who are practicing experts. Volume 1 will be useful to all neuroscientists since it concerns those procedures used routinely across the widest range of s- drsciplines. Collecting these general techniques together in a single volume stnkes us not only as a service, but will no doubt prove of exceptional utilitarian value as well. Volumes 2 and 3 describe all current procedures for the analyses of ammes and theirmetabolites and of amino acrds, respectively. These collections will clearly be of value to all neuroscientists working in or contemplating research in these fields. Similar reasons exist for Volume 4 on receptor binding techniques since experimental details are provided for many types of ligand-receptor binding, including chapters on general prin- ples, drug discovery and development, and a most useful app- dix on computer programs for Scatchard, nonlinear, and compe- tive displacement analyses. Volume 5 provides procedures for the assessment of enzymes involved in biogenic amine synthesis and catabolism. Volumes in the NEUROMETHODS series will be useful to neurochemists, -pharmacologists, -physrologists, -anatomists, psychopharmacologists, psychiatrists, neurologists, and chemists (organic, analytical, pharmaceutical, medicinal); in fact, everyone involved in the neurosciences, both basic and clinical.
Author: Dorothy T. Krieger
Publisher: Wiley-Interscience
ISBN:
Category : Medical
Languages : en
Pages : 1054
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Book Description
The first major comprehensive overview of the anatomical, physiological, evolutionary, and embryological aspects of brain peptides, focusing on peptides described in the past decade. Examines the role of peptides in affecting major homeostatic systems. Presents the methodologies applicable to the study of brain peptides. Summarizes current knowledge of individual peptides.
