The Effector Mechanisms Mediating Corneal Allograft Rejection PDF Download
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Author: Sushma Hedge
Publisher:
ISBN:
Category :
Languages : en
Pages : 380
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Book Description
Author: Sushma Hedge
Publisher:
ISBN:
Category :
Languages : en
Pages : 380
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Book Description
Author: Göran Lundgren
Publisher:
ISBN:
Category :
Languages : sv
Pages : 80
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Book Description
Author: Douglas J. Coster
Publisher:
ISBN:
Category : Cornea
Languages : en
Pages : 4
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Book Description
Author: Yasmin Alam
Publisher:
ISBN:
Category :
Languages : en
Pages : 230
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Book Description
Author: Göran Lundgren
Publisher:
ISBN:
Category :
Languages : en
Pages : 80
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Book Description
Author: T. H. Flynn
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Despite significant advances in our knowledge of the cellular and molecular elements of transplant immunology the 10 year survival probability for all human corneal grafts is 0.73. In some "high-risk" recipients it is as low as 0.37. To date almost all our knowledge about the cellular events during acute corneal graft rejection comes from animal models. In mice, the presence of pre-existing host corneal vascularisation confers "high-risk" status on a graft and has been shown to accelerate rejection. In the first part of this thesis the effect on survival of grafting to an inflamed conjunctival bed was investigated. Using a mouse model of allergic conjunctivitis significantly reduced survival was seen in graft recipients with perioperative conjunctival inflammation. This appeared to be due to the local effects of conjunctivitis rather than systemic effects of allergy/ atopy. Subsequent experiments investigated the effect of perioperative allergic conjunctivitis on the cellular components of both early (surgical trauma-induced, alloantigen-independent) and late (alloantigen-dependent; rejection) post-keratoplasty anterior segment inflammation and demonstrated significant effects on both. Grafts recipients with allergic conjunctivitis had significantly greater early post-operative corneal inflammation and associated corneal and conjunctival lymphangiogenesis. Analysis of graft infiltrating cells during rejection in mice confirmed that large numbers of CD4+ cells, CD8+ cells and macrophages were recruited. Flow cytometric analysis of human aqueous during acute endothelial rejection demonstrated for the first time the presence of CD4+ cells, CD8+ cells and a surprisingly high proportion of macrophages therein. In mouse recipients with allergic conjunctivitis eosinophils were found in both the graft itself and the ciliary body during rejection although the role of these cells during rejection is uncertain. Chemokine analysis during both murine and human corneal graft rejection demonstrated increased expression of the chemokine IP-10 (CXCL-10) suggesting a potentially important role for this protein in the rejection process.
Author: Andreas Martinus Maria Miltenburg
Publisher:
ISBN:
Category :
Languages : nl
Pages : 157
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Book Description
Author: Ruth Porter
Publisher: John Wiley & Sons
ISBN: 0470717653
Category : Medical
Languages : en
Pages : 374
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Book Description
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: John Clifford Hill
Publisher: Kugler Publications
ISBN: 9789062991273
Category : Cornea
Languages : en
Pages : 158
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Book Description
Basic immunology relating to corneal graft rejection is presented in this book. All aspects of corneal graft rejection, from the historical perspective to the diagnosis, treatment and prevention of corneal graft rejection, are discussed. The author includes controversial topics such as the roles of systemic immunosuppressant agents and tissue matching.
